Nothing New Under the Sun Experiences with Mercury Poisoning Related by Dr. Alfred Stock and Dr. E. Jaensch in 1926. The following is a translation by Mats possible that my problems were caused by an Hanson of an article by Dr. Stock which especially narrow nasal passage and an unusual appeared in 1926 in Zeitschrift fur Ange- sensitivity of the nasal mucosa. My nose was wandte Chemie Vol. 39. therefore treated for decades by etching, burning, massage, electricity and bloody operations. Without When I decide to tell a wider audience results! Two years ago something happened — a everything about personal troubles, which in few of my collaborators fell ill with similar themselves do not concern others and therefore symptoms — and it was revealed that the cause was should not be worth publishing, it is because of an insidious mercury intoxication. Because of my an intense wish to spare others, who have chemical work; the study of volatile compounds anything to do with metallic mercury, the very with vacuum technique using vessels with mercury, bad experiences which have destroyed a major mercury-pumps, manometers and valves, I was for part of my life and to very emphatically warn 25 years in constant contact with mercury. against the volatile metal. I can freely tell about It is today not possible to doubt the causal it today since it is fortunately enough in the connection since all symptoms, even if not yet past and a terminated matter. completely, have disappeared (and a short time ago The insidious dangers of mercury are not clearly reappeared when I for some time worked in sufficiently known and are too little noticed just mercury-containing air because of a mishap with in the places where people are especially the ventilation of my laboratory) when I, for two threatened, that is in the chemical and physical years have protected myself from inhalation of laboratories, mercury vapor. For nearly 25 years I experienced symp- I will next give an account of my symptoms and toms, in the beginning only weak and occa- how they developed with time. They agree, even in sional, in time increasing up to being unbear- detail, with all insidious mercury vapor poisonings, able which caused me to doubt if I could something my collaborators and other chemists continue my scientific work. The cause was not could confirm. They were and are, largely known to me or any of many excellent doctors I unknowingly, victims of mercury vapor poisoning visited to ask for advice. It was considered and did 202 NOTHING NEW UNDER THE SUN not know the source of their troubles. Many in various places, stabbing pains in my back and in essential symptoms have, until now, not been limbs, pressure around the liver, sudden need for sufficiently described and the insidious urination and diarrheas without special reasons. mercury vapor poisoning has not received the Slight vesicles on the inner sides of my arms and on attention it deserves. the upper half of my legs. The matter started with me as periodically The manifestation which was most severe for a occurring light headaches and weak dizziness person with intellectual work was the loss of which increased with the years to continuous, memory. My originally very good memory got nervous unrest and irritability, to a pressure on worse and worse so that I, two years ago, was near my head which made thinking difficult, to ever total amnesia. Only with the help of extensive notes increasing headache, finally almost continuous and with considerable effort was it possible to write and tormenting (mostly over the eyes), to a paper or hold a lecture. I would forget the phone intense vertigo which was connected with number on my way from the telephone directory to troubles of vision (dim and double vision). the telephone; I would forget almost everything I Soon also the upper airways were affected; in had learnt by heart, the contents of books and the beginning light and occasional nasal theatre plays I had recently read and seen, the catarrh, then permanently tight nose, later contents of my own papers I had published. It was almost continuous catarrhs of the olfactory impossible for me to remember numbers or names. mucosa with often bloody mucus production Often I could not remember the names of close and crust formation, violent throat friends. Especially the ability to calculate, to do inflammations and pains in my ears connected mathematical thinking, also to play chess, was with depression of hearing and smell (for some severely affected. The depressed ability to substances like hydrogen cyanide it remained), remember and the difficulties in calculating seem to distaste for tobacco smoke. In the last few be a special sign of insidious mercury vapor years before the cause was recognized, other poisoning. This was also evident with my symptoms appeared: salivation, sour-stale taste collaborators and with other persons, for a long in my mouth, eye inflammation, inflammation time exposed to mercury vapors, cases which have of the oral mucosa and vesicles, sensitive and now become known to me. Shortly after we had ulcerating spots on my tongue, gums, gingiva, discovered what was wrong, I and two collaborators insides of lips and cheeks, redness of gums and were trying to finish writing a paper which needed slight bleeding during toothbrushing, calculations. None of us had the ability to add 10- toothache, withdrawal of gingiva from teeth 20 large numbers without errors! and the appearance of pockets, occasional In contrast to only a small effect on bodily loose, single teeth. The mouth and teeth strength, for instance during mountain climbing, the changes occurred late with me (the peak of intellectual capacity was also in other ways these symptoms did not occur until months depressed although not as severely as memory. In after the poisoning had been discovered) since I addition there was psychic depression, a painful from childhood had been careful with my inner unrest, with time also causing disturbed sleep. mouth hygiene (for instance every evening 1 By nature fond of company and full of enjoyment prolonged rinsing with 1 /2 percent hydrogen of life, I withdrew in misery into myself, avoided peroxide solution and then with sodium public relations, people and social contacts, lost the bicarbonate). If this had not been the case I love for art and nature. Humor rusted in. might have discovered the cause of the Difficulties which I earlier had cleared with ease symptoms earlier because of the mouth (and today again can clear with ease) appeared inflammations. insurmountable. The scientific work required Further symptoms were: intellectual ex- considerable efforts. I forced myself into my haustion and depression, lack of energy and laboratory but could not produce anything of value ability for work, especially intellectual work, despite all efforts. My thoughts were heavy and increased need for sleep, trembling of my pedantic. stretched fingers, often also my eyelids, pains 203 ORTHOMOLECULAR PSYCHIATRY, VOLUME 12, NUMBER 3,1983 Pp. 202-207 I had to give up participating in matters which in a small room. The measurements required were not of immediate importance. The constant temperature and therefore windows and lectures, previously something I liked, became doors were kept closed. The work had to be tormenting. The preparation of a lecture, the finished before early 1924 since my assistant was to writing of a paper, even a simple letter, take up a post in industry and the Spanish colleague required immense efforts in handling the had to go back to his home country. Therefore the contents and language. Not seldom it happened work was rushed and the careful cleanliness we at that I wrote words wrongly or forgot letters. To other times kept, was neglected in this room and be aware of these shortcomings, not to know scattered mercury was left unattended in cracks and their cause, to know no way of getting rid of joints in the floor and under laboratory stands. In- them, to expect further deterioration — that stead of an insidious mercury poisoning the was not nice. conditions were given for a more acute and more All efforts to improve my condition failed. easily recognizable mercury intoxication. The Several weeks in the mountains was of no use; assistant fell severely ill, not just with headaches I did not feel less miserable there than in and intellectual depression but also with severe Berlin. The nasal treatments and operations bodily deterioration, ulcers in the mouth etc. His often gave short, not lasting improvements. It brother, a doctor, thought that the condition was remarkable that all psychic symptoms reminded him of mercury poisoning. The renowned disappeared for hours when the doctor treated toxicologist, L. Lewin, whom we called for, certain places of the upper nasal mucosa with examined the laboratory personnel and declared, cocaine; if the correct spot was treated, that according to his experiences, we were all with headache and vertigo disappeared, often within certainty suffering from mercury poisoning. a few minutes. Memory, ability to work and Mercury was found in the air of the laboratories good spirits reappeared, however, only as as well as in the urine of all affected persons. The passing guests. I often used the method to recall mercury concentration in the air varied from room my ability before a lecture, an important to room, from a few thousandths to a few meeting etc. hundredths of a milligram per cubic meter. That is As I have already mentioned, also my only a small fraction of what air can contain when collaborators in the laboratory; assistants, Ph.D. saturated with mercury vapor (about 12 mg/m3). students, technicians, had various symptoms: Since a human being breathes about 1/2 m3 air each depression without apparent cause, bad hour and the inhaled mercury, as it appears, is memory, headaches and dizziness, now and largely absorbed in the lungs, only a short visit in then gastrointestinal troubles, limb pains, slight mercury saturated air is sufficient to elicit an acute mouth inflammations, nasal catarrh etc.