Cardiovascular diseases and stroke afflict people of all races, ethnicities, genders, religions, ages, sexual orientations, national origins and disabilities. The American Heart Association is committed to ensuring that our workforce and volunteers reflect the world’s diverse population. We know that such diversity will enrich us with the talent, energy, perspective and inspiration we need to achieve our mission: building healthier lives, free of cardiovascular diseases and stroke. For information on upcoming American Heart Association Scientific Conferences, visit professional.heart.org Basic Cardiovascular Sciences 2018 Scientific Sessions: Innovating in Cardiovascular Research Final Program July 30-August 2 | Grand Hyatt San Antonio | San Antonio, Texas BCVS Abstracts are available online: http://professional.heart.org/bcvssessions National Center 2018 Sponsored and organized by the Council on Basic Cardiovascular Sciences. 7272 Greenville Avenue Dallas, Texas 75231–4596 ©2018, American Heart Association 6/18LN2373 professional.heart.org/bcvs Program at a Glance Sunday July 29 Monday July 30 Tuesday July 31 Wednesday August 1 Thursday August 2 7:00 AM 7:00–8:00 AM 7:00–8:00 AM 7:00–8:00 AM Women in Science Breakfast Continental Breakfast/ Continental Breakfast/ Ticket required to attend Registration/Exhibits Registration Life is why. Continental Breakfast/ Registration/Exhibits Research and Patient Care are how. 8:00 AM 8:00 AM 8:00–9:15 AM 8:00–9:15 AM 8:00–9:00 AM Registration/Exhibits Concurrent Sessions Concurrent Sessions General Session 13 The American Heart Association Professional Membership is where you’ll find 3A: Emerging Cardiac 8A: Personalized Basic Science and Therapeutic Strategies Cell Models of Precision Medicine – the richest source of cardiovascular science and news. Enhance your knowledge, 3B: Excitation-Contraction Cardiovascular Disease The Interface experience and networking with a membership today! Coupling 8B: Getting the Message – New Ways to Think Professional Membership Benefits Include:* About RNA • Up to $400 in savings on AHA’s scientific conferences 9:00 AM 9:15–10:00 AM 9:00–9:30 AM General Session 9 Refreshment Break • Unprecedented access to research and clinical information 9:30 AM 9:45–10:00 AM 9:15–9:45 AM Outstanding Early Career 9:30–10:45 AM across multiple specialties Early Career Pre- Refreshment Break/Exhibits Investigator Award General Session 14 Competition Conference Session Metabolic Pathways to • Online access to all 11 AHA scientific journals of your choice* Opening Welcome Cardiovascular Disease • Complimentary access to Sessions OnDemandTM* 10:00 AM 10:00–11:15 AM 9:45–11:00 AM 10:00–10:30 AM Early Career Pre- Concurrent Sessions Refreshment Break/ *dependent on membership tier Conference Session 1 4A: Transcriptional Regulation Exhibits 10:30 AM “Next Big Thing” in and Epigenetics 10:30–11:45 AM 10:45–11:45 AM Cardiovascular Research 4B: How to Build a New Heart Concurrent Sessions General Session 15 One Cell at a Time 10A: Early Career Session – Novel Cardiac Navigating Your Regulatory Mechanisms 11:00 AM 11:15–11:50 AM 11:00 AM–Noon Career: Finding Members are where it happens Early Career Pre- General Session 5 Success and Learn about the benefits of professional membership and join our Conference Session 2 Keynote Lecture Happiness with a PhD network of more than 33,000 members today at professional.heart.org. 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Featured Presentation 10B: Workshop 2 – Toward Single Cell Analysis NOON Noon–1:00 PM 11:50 AM–12:35 PM Noon–1:30 PM 11:45 AM–1:30 PM 11:45 AM ACRE Meeting Break/Lunch on your own Early Career Luncheon Lunch on your own; Closing Remarks/ (Academy of Speed Networking/Mentoring Poster Viewing; Exhibits Adjourn Cardiovascular Round Tables 1:00 PM 12:35–1:00 PM Research Opening Welcome OR Excellence) Lunch on your own; Poster viewing; Exhibits Legend 1:30 PM 1:00–2:35 PM 1:30–2:45 PM 1:30–2:45 PM Concurrent Sessions Concurrent Sessions Concurrent Sessions 2:00 PM 1A: Cardiac Fibrosis 6A: Ion Channels and 11A: The Architecture of – Changing the Arrhythmias Contraction Plenary Session Landscape 6B: The Resurgence of Cardiac 11B: Cell Death and 1B: The On and Off of Metabolism Cardiomyopathy Redox 3:00 PM 2:35–3:05 PM 2:45–3:15 PM 2:45–3:15 PM Refreshment Break/ Refreshment Break/Exhibits Refreshment Break/ Poster Session Basic Cardiovascular Sciences Exhibits Exhibits 3:30 PM 3:05–4:40 PM 3:15–4:30 PM 3:15–4:30 PM Scientific Sessions 2019 Concurrent Sessions Concurrent Sessions Concurrent Sessions 2A: Signaling Networks in 7A: Functional Genomics and 12A: Workshop 3 – Single Cardiac Myocyte Pathogenicity Assessment and Multi-omics Meals/Breaks July 29-August 1 | Westin Boston Waterfront Hotel | Boston, Massachusetts 2B: Mitochondrion and 7B: Workshop 1 – Imaging in 12B: Cardiovascular Stress Heart Failure vitro and in vivo and Inflammation 4:00 PM 4:40–7:00 PM 4:30–7:00 PM 4:30–7:00 PM Poster Session 1 Poster Session 2 Poster Session 3 5:00 PM Other and Reception and Reception and Reception 6:00 PM 7:00 PM 7:00 PM 7:00–10:00 PM Early Career Investigator Council Dinner SAVE THE DATE! Social Event Ticket required to attend AHA MEMBERS SAVE UP TO $300 OFF REGISTRATION! PROFESSIONAL.HEART.ORG/BCVSSESSIONS Table of Contents: Abstracts: Abstracts .................................................................................. 28 Author Index ............................................................................. 63 Conference Highlights: Awards ..................................................................................... 16 Early Career Activities and Ticketed Events ............................... 15 Keynote Lecture ....................................................................... 14 Contact Information .................................................................... 2 General Information: CME/CE ................................................................................... 11 Learning Objectives .................................................................. 10 Registration Hours .................................................................... 10 Information for Presenters: Abstract Presentations .............................................................. 13 Speaker Resource Room .......................................................... 13 Invited Presenters and Panelists ...................................................... 5 Invited Moderators ........................................................................... 6 Letter from the Chairs ...................................................................... 3 Policy Information .......................................................................... 17 Program Agenda Monday, July 30 ....................................................................... 18 Tuesday, July 31 ....................................................................... 20 Wednesday, August 1 ............................................................... 23 Thursday, August 2 ................................................................... 26 Program Committee ........................................................................ 4 Room Locator ................................................................................. 9 Questions and Information Questions If you have questions after reading this program, contact the American Heart Association National Center: Telephone: 888.242.2453 (inside the United States) 214.570.5935 (outside the United States) Fax: 214.373.3406 Email: [email protected] Website: professional.heart.org Professional Membership Customer Service Lippincott Williams & Wilkins Telephone: 800.787.8984 (inside the United States) 301.223.2307 (ooutside the United States) Fax: 301.223.2327 Email: [email protected] For information on upcoming American Heart Association Scientific Conferences, visit professional.heart.org To access a schedule of future conferences sponsored by AHA, follow these simple steps: • From the home page, click on the “Education & Meetings” tab in the upper navigation bar. • Select the conference you’re interested in attending for more details, such as Registration & Housing, Programming, and Abstracts and Awards. • If you have additional questions, please email us at [email protected] or call toll-free 888.242.2453 2 Become an AHA/ASA Professional Member and save up to $300 off next year’s registration. (professional.heart.org/membership) Letter From the Chairs Dear Colleague, On behalf of the American Heart Association and the Scientific Council on Basic Cardiovascular Sciences, welcome to the Basic Cardiovascular Sciences 2018 Scientific Sessions: Innovating in Cardiovascular Research. The conference is considered by many to be the premier basic and translational cardiovascular research meeting in the world and attracts our field’s best and brightest from across the globe. Our primary goal is to provide a forum for timely discussion of the latest findings from leaders in the field of cardiovascular sciences. As a result, we hope the conference will foster new ideas and collaborations to accelerate translation. We’re pleased to announce some new programming this year, including the Early Career Pre-conference Session on Monday morning, concurrent sessions throughout the meeting to expand your educational experience, workshops and early career sessions. Attendees will hear state-of-the-art presentations on a broad array of topics, including cardiac fibrosis – changing the landscape, the on and