SunLong Biotech Co.,LTD Tel: 0086-571- 56623320 Fax:0086-571- 56623318 E-mail:[email protected] www.sunlongbiotech.com Rabbit Anti-TIMM50/FITC Conjugated antibody SL19932R-FITC Product Name: Anti-TIMM50/FITC Chinese Name: FITC标记的Mitochondrion内膜转位同源蛋白50抗体 Homolog of yeast Tim50; Import inner membrane translocase subunit TIM 50; Import inner membrane translocase subunit TIM50; Import inner membrane translocase subunit TIM50 mitochondrial; MGC102733; Mitochondrial import inner membrane Alias: translocase subunit TIM50; TIM 50; TIM 50L; TIM50; Tim50 like protein; TIM50_HUMAN; TIM50L; TIMM 50; TIMM50; Translocase of inner mitochondrial membrane 50 homolog (yeast); Translocase of inner mitochondrial membrane 50 homolog. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 35kDa Form: Lyophilized or Liquid Concentration: 1mg/mlwww.sunlongbiotech.com immunogen: KLH conjugated synthetic peptide derived from human TIMM50 Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Function: Essential component of the TIM23 complex, a complex that mediates the translocation Product Detail: of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. Subunit: Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM23. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. Subcellular Location: Mitochondrion inner membrane and Nucleus speckle. Nuclear and enriched in speckles with snRNPs. Tissue Specificity: Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level). Similarity: Belongs to the TIM50 family. Contains 1 FCP1 homology domain. Database links: Entrez Gene: 92609 Human Entrez Gene: 66525 Mouse Entrez Gene: 685725 Rat Omim: 607381 Human SwissProt: Q3ZCQ8 Human SwissProt: Q9D880 Mouse Unigene:www.sunlongbiotech.com 590956 Human Unigene: 597106 Human Unigene: 167913 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. .