Cochrane Library Cochrane Database of Systematic Reviews Withdrawal of antihypertensive drugs in older people (Review) Reeve E, Jordan V, Thompson W, Sawan M, Todd A, Gammie TM, Hopper I, Hilmer SN, Gnjidic D Reeve E, Jordan V, Thompson W, Sawan M, Todd A, Gammie TM, Hopper I, Hilmer SN, Gnjidic D. Withdrawal of antihypertensive drugs in older people. Cochrane Database of Systematic Reviews 2020, Issue 6. Art. No.: CD012572. DOI: 10.1002/14651858.CD012572.pub2. www.cochranelibrary.com Withdrawal of antihypertensive drugs in older people (Review) Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Trusted evidence. Informed decisions. Library Better health. Cochrane Database of Systematic Reviews T A B L E O F C O N T E N T S HEADER......................................................................................................................................................................................................... 1 ABSTRACT..................................................................................................................................................................................................... 1 PLAIN LANGUAGE SUMMARY....................................................................................................................................................................... 2 SUMMARY OF FINDINGS.............................................................................................................................................................................. 4 BACKGROUND.............................................................................................................................................................................................. 7 OBJECTIVES.................................................................................................................................................................................................. 7 METHODS..................................................................................................................................................................................................... 7 RESULTS........................................................................................................................................................................................................ 10 Figure 1.................................................................................................................................................................................................. 11 Figure 2.................................................................................................................................................................................................. 13 Figure 3.................................................................................................................................................................................................. 14 Figure 4.................................................................................................................................................................................................. 16 Figure 5.................................................................................................................................................................................................. 17 Figure 6.................................................................................................................................................................................................. 18 DISCUSSION.................................................................................................................................................................................................. 19 AUTHORS' CONCLUSIONS........................................................................................................................................................................... 21 ACKNOWLEDGEMENTS................................................................................................................................................................................ 22 REFERENCES................................................................................................................................................................................................ 23 CHARACTERISTICS OF STUDIES.................................................................................................................................................................. 27 DATA AND ANALYSES.................................................................................................................................................................................... 45 Analysis 1.1. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 1: All- 47 cause mortality...................................................................................................................................................................................... Analysis 1.2. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 2: 47 Cardiovascular mortality...................................................................................................................................................................... Analysis 1.3. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 3: 48 Myocardial infarction (fatal and nonfatal)........................................................................................................................................... Analysis 1.4. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 4: 48 Systolic blood pressure........................................................................................................................................................................ Analysis 1.5. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 5: 48 Diastolic blood pressure....................................................................................................................................................................... Analysis 1.6. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 6: 49 Hospitalisation...................................................................................................................................................................................... Analysis 1.7. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 7: Stroke 49 (fatal + nonfatal + TIA).......................................................................................................................................................................... Analysis 1.8. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 8: Sucess 49 rate - withdrawal/resumption due to hypertension or other clinical reason.................................................................................... Analysis 1.9. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 9: Quality 50 of life...................................................................................................................................................................................................... Analysis 1.10. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 10: 50 Systolic blood pressure subgrouped on duration.............................................................................................................................. Analysis 1.11. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 11: 51 Systolic blood pressure subgrouped on drug type............................................................................................................................ Analysis 1.12. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 12: 51 Diastolic blood pressure subgrouped on duration............................................................................................................................. Analysis 1.13. Comparison 1: Discontinuation by no treatment/placebo of antihypertensives vs Continuation, Outcome 13: 52 Diastolic blood pressure subgrouped on drug type........................................................................................................................... ADDITIONAL TABLES.................................................................................................................................................................................... 52 APPENDICES................................................................................................................................................................................................. 53 HISTORY........................................................................................................................................................................................................ 58 CONTRIBUTIONS OF AUTHORS..................................................................................................................................................................