US 2013 0071525A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0071525 A1 Kanaya et al. (43) Pub. Date: Mar. 21, 2013 (54) COATING FAT COMPOSITION AND Publication Classification PARTICULATE COMPOSITION USING THE SAME (51) Int. Cl. A2.3L. I./00 (2006.01) (75) Inventors: Kento Kanaya, Takasago-shi (JP); Masayuki Abe, Takasago-shi (JP); Akio (52) U.S. Cl. Sakaki, Takasago-shi (JP); Masao Sato, CPC .................................... A23L I/0029 (2013.01) Takasago-shi (JP) USPC .............................. 426/99: 426/609: 426/601 (73) Assignee: KANEKA CORPORATION, Osaka-shi, Osaka (JP) (57) ABSTRACT (21) Appl. No.: 13/638,137 A particulate composition, wherein a hydrophilic Substance (22) PCT Fled: Mar. 29, 2011 is polydispersed in a matrix of a fat composition having a solid fat content at 25 C of 58% or more and a solid fat content (86) PCT NO.: at 37 C of 90% or less; and a coating fat composition con S371 (c)(1), taining 45% by weight or more of a triglyceride comprising at (2), (4) Date: Dec. 5, 2012 least both a saturated fatty acid having 6 to 12 carbon atoms and a Saturated fatty acid having 14 or more carbon atoms as (30) Foreign Application Priority Data constituent fatty acids, wherein the proportion of the satu Mar. 29, 2010 (JP) ................................. 2010-075.256 rated fatty acid having 14 or more carbon atoms in the con Nov. 4, 2010 (JP) ................................. 2010-247766 stituent fatty acids of the whole fat exceeds 50% by weight. Patent Application Publication Mar. 21, 2013 US 2013/0071525 A1 Fig. 1 US 2013/007 1525 A1 Mar. 21, 2013 COATING FAT COMPOSITION AND Document 4), but there are problems, such as the deformation PARTICULATE COMPOSITION USING THE of a coating fat during storage and the Sticking of coating fats. SAME 0008 Moreover, as to enteric properties, a coating fat is required to have a characteristic that it does not disintegrate in TECHNICAL FIELD the stomach in oral ingestion, and it rapidly releases the enclosure on arrival at the intestines. However, it is hard to be 0001. The present invention relates to a particulate com said that a conventional coating fat sufficiently satisfies the position in which a hydrophilic Substance is polydispersed in above characteristic. a matrix of a fat composition, and to a coating fat composition 0009 Patent Document 1: JP-A-2003-252751 that is a Solid at room temperature. O010 Patent Document 2: JP 4038585 0011 Patent Document 3: JP-A-2004-143084 BACKGROUND ART 0012 Patent Document 4: JP-A-2003-61576 0002 An S/O type or W/O type microcapsule can be employed for various applications such as foods, functional DISCLOSURE OF THE INVENTION nutritive foods, specific health foods, medicines, cosmetics, feeds, and agrochemicals, by enclosing an useful component Problems to be Solved by the Invention (core Substance) in a predominately solid fat phase. For 0013 An object of the present invention is to provide a fine microcapsules to be used for Such applications, there are particulate composition which is a Solid at room temperature, demands not only for an increase in yield, a high content of a which has excellent oxidative stability, which encapsulates a core Substance, and a wide choice range of capsule particle large quantity of an enclosure such as a hydrophilic Sub diameter but also for control of a pattern of the release of a stance, which, when coating the enclosure, causes only mini core substance from the viewpoint of DDS. mal heat-induced damage to the enclosure, which has enteric 0003. On the other hand, examples of the S/O type micro properties to be capable of rapidly releasing the coated enclo capsules heretofore known include microcapsules produced Sure when the composition reaches the intestines, and which by the in-liquid drying process (Patent Document 1). Such can be employed for a wide variety of applications such as microcapsules are difficult to use for food applications foods and medicines; and a fat composition which can be used because organic solvents harmful to the human body, Such as in the particulate composition. halogenated hydrocarbons or ethers, are used in their produc tion. Moreover, the microcapsules produced by the in-liquid Means for Solving the Problems drying process can be used as controlled release microcap 0014. The present inventors have investigated earnestly in Sules, but they are problematic in that physical fine pores order to solve the aforementioned problems of the present appeareasily in a capsule casing, a core substance easily leaks invention and, as a result, they have found that a particulate out of the casing or the like. composition using a fat composition having a solid fat content 0004. There has been proposed an S/O type microcapsule within a specific range as a matrix can encapsulate a hydro produced by preparing a fine W/O/W emulsion by membrane philic Substance in a high content and also control the release emulsification using a solid fatas a shell material, followed by of an enclosed hydrophilic Substance in the intestinal tract, freeze-drying (Patent Document 2), but it is difficult to and therefore have completed a first invention. enclose a high content of a core Substance and there are 0015 That is, the first present invention relates to a par problems, such as pressure loss or clogging during membrane ticulate composition, wherein a hydrophilic Substance is emulsification and durability of membranes. polydispersed in a matrix of a fat composition having a solid 0005 Moreover, there are known a W/O type or S/O type fat content at 25 C of 58% or more and a solid fat content at 37 microcapsule in which a hydrophilic bioactive Substance has C of 90% or less. A preferred embodiment thereof relates to a been coated with tripalmitin and a method for its production particulate composition, wherein the fat composition is com by spray drying (Patent Document 3). In this document, the posed of 95 to 60% by weight of a high-melting-point fathigh release characteristic of an enclosed Substance has been melting-point fat and 5 to 40% by weight of a low-melting revealed by immersing the microcapsule in a simulated intes point oil. tinal fluid containing lipase. However, the microcapsule fails 0016. Moreover, the present inventors have investigated to exhibit a sufficient rate in releasing the enclosure in spite of earnestly in order to solve a problem of a second present the fact that it is a fine particle produced by spray-drying. invention and, as a result, they have found that a fat compo 0006 Moreover, since the melting point of the tripalmitin sition having a specific Saturated fatty acid composition as a to be used is high, this method requires an operation of bring constituent fatty acid can be processed at low temperatures ing the enclosure into contact with tripalmitin molten at a high because its melting point is not very high, but it can hold its temperature of 70 C or higher when dispersing the enclosure Solid state at room temperature and is excellent in oxidative in a fat. For this reason, in the event that a material having low stability and also it exhibits excellent enteric properties by heat resistance is used for the enclosure, there is a problem coating an enclosure with the fat composition, and therefore that the deterioration or damage of the enclosure is caused, so have completed the second invention. that expected bioactive effects fail to be demonstrated suffi 0017. That is, the second present invention relates to a ciently. coating fat composition containing 45% by weight or more of 0007 Incidentally, coating fats are used as base materials a triglyceridehaving at least both a saturated fatty acid having of microcapsules enclosing bioactive Substances as described 6 to 12 carbon atoms and a Saturated fatty acid having 14 or above and also are in use for coating of foods, and the like. On more carbon atoms as constituent fatty acids, wherein the the other hand, in conventional coating of foods, for example, proportion of the saturated fatty acid having 14 or more semi-solid fats have been used for coating Snack foods (Patent carbon atoms in the constituent fatty acids of the whole fat US 2013/007 1525 A1 Mar. 21, 2013 exceeds 50% by weight. The coating fat composition can be 0026. The fat composition to be used for the particulate used as the fat composition in the first present invention. composition of the present invention is not particularly restricted as far as its solid fat content at 25 C is 58% or more Effects of the Invention and its solid fat content at 37 C is 90% or less as described above. A fat composition having a solid fat content at 25 C of 0018. According to the present invention, there can be less than 58% cannot exhibit solidity at normal temperature provided a fine particulate composition which is a Solid at (usually 25C); even if such a fat composition is used, it is not room temperature, which has excellent oxidative stability, possible to produce a particulate composition or, even if it is which can include an enclosure such as a hydrophilic Sub possible, a resulting particulate composition will be particles stance at a high content, and further which, when coating the which are semi-solid and sticky at normal temperature and it enclosure, causes only minimal heat-induced damage to the will be very difficult to handle the particles due to the occur enclosure because the coating can be performed at an opera rence of sticking of the particles together or the like.