WWW.HISTIOCYTESOCIETY.ORG 2 HISTIOCYTE SOCIETY ANNUAL MEETING 2016 TABLE OF CONTENTS WELCOME TO IRELAND ....................................................................................................................................................................... 5 ABOUT THE HISTIOCYTE SOCIETY .................................................................................................................................................... 6 2016 ANNUAL MEETING MOBILE APP ............................................................................................................................................... 6 ANNUAL MEETING PROGRAM ............................................................................................................................................................ 6 HISTIOCYTOSIS ASSOCIATION AND HISTIOCYTE SOCIETY .......................................................................................................... 7 ACKNOWLEDGEMENTS AND RECOGNITIONS ................................................................................................................................. 8 AT-A-GLANCE MEETING AGENDA ................................................................................................................................................... 10 GUEST SPEAKER HIGHLIGHTS ........................................................................................................................................................ 12 MEETING AGENDA ............................................................................................................................................................................. 14 GUEST SPEAKER PRESENTATION ABSTRACTS ........................................................................................................................... 27 SCIENTIFIC SESSION I ABSTRACTS ................................................................................................................................................ 32 SCIENTIFIC SESSION II: PRESIDENTIAL SYMPOSIUM ABSTRACTS ............................................................................................ 35 SCIENTIFIC SESSION III ABSTRACTS .............................................................................................................................................. 38 POSTER PRESENTATION SESSION ABSTRACTS .......................................................................................................................... 41 SCIENTIFIC SESSION IV ABSTRACTS .............................................................................................................................................. 76 NESBIT PRIZE IN CLINICAL SCIENCE .............................................................................................................................................. 78 NEZELOF PRIZE IN BASIC SCIENCE ................................................................................................................................................ 78 HISTIOCYTE SOCIETY GOVERNING BY-LAWS ............................................................................................................................... 79 HISTIOCYTE SOCIETY CONSTITUTION ............................................................................................................................................ 81 PRESENTING AUTHOR INDEX ........................................................................................................................................................... 82 MEETING SPONSORS WWW.HISTIOCYTESOCIETY.ORG 3 4 HISTIOCYTE SOCIETY ANNUAL MEETING 2016 WELCOME TO DUBLIN Dear Colleagues, I am thrilled to welcome you to Dublin, Ireland for the 32nd Annual Meeting of the Histiocyte Society, October 17-19, 2016. Our meeting venue, the Killashee Hotel, located in the picturesque countryside of Naas, Co. Kildare, exudes Irish charm and sophistication. It is the perfect blend of historic architecture and modern day amenities with plenty of space to accommodate our growing group. The Board and the Program Committee have prepared a very exciting program that we hope will continue to represent the scientific advances made during the last year while facilitating interactions and development of new collaborations. In addition to our scientific sessions, we have prepared two symposia: one to discuss advances in target therapies for LCH and ECD and another to look at the future of therapies for HLH. We have assembled a great group of speakers that I am sure will make the meeting memorable. Following the success of last year, we will once again be integrating the use of our Annual Meeting Mobile App into the program. As technology advances and we seek to offer attendees the best possible experience, this mobile app will expand the opportunities for interaction, collaboration and information sharing right at your fingertips. The app is available for all Apple and Android devices by searching “Histiocyte Society” in your app store or visiting www.histiocytesociety.org/app. This year’s app also features a fully functional website version for those using a laptop. Another highlight of the meeting each year is the Annual Banquet. This year’s banquet will be held at the Guinness Storehouse, located in the heart of the St. James's Gate Brewery in Dublin. Attendees are invited to explore the Storehouse through a self-guided tour, ending with the opportunity to learn how to “pull the perfect pint,” complete with the shamrock design in the head. As you know, a great deal of time, energy and resources go into planning the meeting each year. We are grateful to our annual key sponsor, the Histiocytosis Association, without whose generous support, this meeting would not be possible. We are also thankful to our other sponsors, the Artemis Association, Histiocytosis UK and Failte Ireland. I hope you take time to enjoy the beauty and charm of Dublin, Naas and the Irish countryside during your stay. There is much to see and experience! As the President of the Histiocyte Society, I look forward to seeing you all over the course of this exciting meeting. Carlos Rodriguez-Galindo President Histiocyte Society WWW.HISTIOCYTESOCIETY.ORG 5 ABOUT THE HISTIOCYTE SOCIETY The Histiocyte Society is a professional medical association comprised of more than 200 physicians and scientists from around the world. Members of the organization are considered to be the leaders in understanding and treating histiocytic disorders. The Society is committed to advancing knowledge about histiocytic disorders and improving outcomes for patients through the planning, development, sponsorship and oversight of clinical research. Building Knowledge The Histiocyte Society hosts an annual scientific meeting in different locations around the world. Attendance is open to members of the Society as well as other professionals working in the field of histiocytic disorders and related studies. Meetings feature presentations of individual and collective research efforts as well as keynote lectures from guest speakers; special-interest groups convene to discuss and develop new and innovative treatment regimes. This interactive forum allows the best and brightest minds in the histiocytosis community to share the most progressive information and to shape the future of research. Beyond the prolific exchanges that occur during the meeting, presenters work collectively to extend their reach by publishing subsequent articles and manuscripts in scientific journals worldwide. Advancing Treatment Through extensive research and collaboration, the Histiocyte Society has made numerous, significant strides in the fight against histiocytic disorders. The Society has established scientific standards for histiocytic disorders that are accepted worldwide; they include: 1) A common language of uniform disease classification, 2) Standardized diagnostic criteria, and 3) Guidelines for patient evaluation and follow-up. The Society remains dedicated to facilitating essential and innovative clinical research – developing critical knowledge and increasingly effective treatments in the pursuit of a cure. 2016 ANNUAL MEETING MOBILE APP The 2016 Histiocyte Society Annual Meeting has a FREE custom mobile app ready for downloading! The app is available on the App Store, Google Play and in HTML5 for Blackberries, Windows phones, older devices and laptops. All of the information in the program book is also in the app, plus much more! Create your own custom agenda, read all of the abstracts, provide feedback about sessions, see what your colleagues are saying, access maps of Dublin, post pictures, and get the latest news and information right at your fingertips! Find it in your app store or go to www.histiocytesociety.org/app on your mobile device. *Standard data and text messaging rates may apply depending on your service provider. ANNUAL MEETING PROGRAM Copyright 2016 by the Histiocyte Society All programs presented at the 2016 Annual Meeting constitute copyrighted presentations owned by the Histiocyte Society. The copyright of the 2016 Histiocyte Society Annual Meeting Program is owned by the Histiocyte Society. The Histiocyte Society reserves the rights to all recordings and reproductions of presentations at this Annual Meeting and all Histiocyte Society educational and scientific meetings. Photography Consent Registration for, attendance at, and participation in the 2016 Histiocyte Society Annual Meeting and other activities constitutes an agreement by the participant