Authors: Chuan Wang Peifen Zhang Pascal Schlapfer Taehyong Kim AraCyc: Arabidopsis thaliana col Cellular Overview Seung Yon Rhee 2+ 2+ + 2+ + 2+ 2+ Cd 2+ Cu 2+ + 2+ 2+ + H Cu H 2+ Cu Cu + Cd Cd H Cd Cu H 2+ 2+ Mn K Fe Fe cadmium/zinc- copper- AT2G18960.1 AT5G21930.1 AT1G20260.1 AT1G10130.1 AT5G44790.1 AT1G63440.1 AT5G55630.1 transporting AT4G30120.1 transporting AT2G19110 AT1G76030 AT4G30110 AT4G33520.2 AT4G38510 AT4G19680.2 AT4G19690.2 ATPase ATPase + 2+ + 2+ 2+ 2+ 2+ + 2+ 2+ + H Cu H 2+ Cu Cu + 2+ Cd 2+ Cd H Cd Cu H 2+ 2+ Mn K Cd Cu Fe Fe SECONDARY METABOLITES DEGRADATION phytate degradation I δ isoleucine AMINO ACIDS BIOSYNTHESIS β biosynthesis I glutamine glutamate histidine biosynthesis -alanine threonine superpathway superpathway of arginine biosynthesis II (acetyl cycle) superpathway of phenylalanine L-N -acetylornithine biosynthesis proline biosynthesis III superpathway of leucine, valine, biosynthesis II of aspartate and and tyrosine biosynthesis ALDEHYDE DEGRADATION and isoleucine biosynthesis biosynthesis III biosynthesis V biosynthesis isoleucine and asparagine biosynthesis valine biosynthesis TCA CYCLE TCA cycle variation V (plant) Ins(1,2,3,4,5,6)P 6 oxaloacetate N-acetylglutamyl- methylglyoxal PRPP propanoate pyruvate oxaloacetate phosphate chorismate pro glt degradation I methylglyoxal thr pyruvate gln 2-oxoglutarate oxaloacetate pyruvate thr d1-pyrroline- degradation III aspartate ATP-phosphoribosyl chorismate mutase: pyruvate 3-phytase: acetolactate pyruvate, transferase: AtATP-PRT1 butyrate- aspartate transaminase: proline 5-carboxylate transaminase: superpathway of phenylalanine, glutamate synthase aspartate N-acetyl-γ- AT3G29200.1 synthase B: AT1G09870.1 synthase: orthophosphate ATP-phosphoribosyl CoA ligase: AT2G22250.2 acetolactate dehydrogenase: methylglyoxal AT2G22250.2 threonine tyrosine and tryptophan biosynthesis (ferredoxin- transaminase: chorismate mutase: AT3G55610.1 L-ornithine methylglyoxal AT3G48560.1 dikinase: transferase: AtATP-PRT2 AT3G16910.1 aspartate threonine synthase: glutamyl-phosphate glt AT3G30775.1 aspartate deaminase: dependent): AT2G22250.2 deaminase: reductase: AT5G10870.1 δ1-pyrroline- [+ 2 isozymes] AT4G15530.5 [+ 3 isozymes] transaminase: ACS12 AT3G48560.1 amino-acid N- d1-pyrroline- proline ornithine-δ- D-myo-inositol D-myo-inositol transaminase: AT3G10050.1 AT5G04140.2 β aspartate AT3G10050.1 AT2G19940.1 chorismate mutase: 5-carboxylate lactoylglutathione aldehyde reductase 1-(5-phospho- - aspartate [+ 2 isozymes] acetyltransferase: 5-carboxylate dehydrogenase: (1,2,4,5,6)- (1,2,3,5,6) ACS12 glutamate synthase transaminase: AT1G69370.1 synthetase: P5CS1 aminotransferase: lyase: AT2G28420.1 (cytosolic): SDR1 chorismate D-ribosyl)-ATP propanoyl-CoA transaminase: ACS10 AT4G37670.2 acetylglutamate synthase B: AT5G38710.1 δ-OAT pentakisphosphate pentakisphosphate aspartate (2Z)-2-aminobut- (S)-2-acetolactate phosphoenolpyruvate (ferredoxin)<p: ACS12 N-acetyl-L- [+ 5 isozymes] aspartate (2Z)-2-aminobut- (S)-2-acetolactate [+ 4 isozymes] N-acetyl-L-kinase: AT3G57560.1 AT3G55610.1 methylglyoxal transaminase: 2-enoate AT2G41220.1 aspartate 2-enoate glt phosphoribosyl-ATP transaminase: ASP2 glutamate glutamate 5- prephenate δ1-pyrroline- (S)-1-pyrroline- reductase: ACS10 ketol-acid transaminase: semialdehyde 5-carboxylate (R)-S- anthranilate pyrophosphohydrolase: aspartate acetylornithine 5-carboxylate AT1G54870.1 aspartate reductoisomerase: phosphoenolpyruvate chorismate mutase: ACS10 gln NAD-dependent malate dehydrogenase lactoylglutathione synthase: AT3G29200.1 glt AT1G31860.1 transaminase: ASP5 ketol-acid transaminase: prephenate synthetase: P5CS1 methylglyoxal transaminase: ASP2 AT3G58610.1 carboxylase: PPC3 aspartate (decarboxylating): NAD-ME2 NAD-ME1 reductase: ChlADR AT5G57890.1 chorismate mutase: [+ 3 isozymes] reductoisomerase: AT1G80600.1 aminotransferase: serine NAD-dependent malate dehydrogenase hydroxyacylglutathione aspartate [+ 4 isozymes] β transaminase: ASP2 L-glutamate-5- methylglyoxal D-myo-inositol anthranilate AT5G10870.1 1-(5-phospho- - AT3G58610.1 AT2G22250.2 (decarboxylating): NAD-ME2 hydrolase: AT1G06130.1 transaminase: ASP5 (R)-2,3-dihydroxy- aspartate carbamoylphosphate racemization semialdehyde reductase: SDR2 D-myo-inositol synthase: chorismate mutase: D-ribosyl)-AMP glutamate N- hydroxyacylglutathione (1,2,3,6) [+ 3 isozymes] 3-methylbutanoate acryloyl-CoA transaminase: ASP5 asp synthase: AT1G29900.1 NAD-dependent malate dehydrogenase methylglyoxal (1,2,5,6) 2-iminobutanoate oxaloacetate AT5G05730.2 (R)-2,3-dihydroxy- acetyltransferase: (S)-malate (decarboxylating): NAD-ME1 acetyl-CoA hydrolase: GLX2-2 tetrakisphosphate AT1G69370.1 [+ 3 isozymes] AT3G27740.1 homomethionine L-arogenate reductase: AKR4C8 tetrakisphosphate anthranilate phosphoribosyl- 2-iminobutanoate 3-methylbutanoate AT2G37500.1 hydroxyacylglutathione dihydroxyacid biosynthesis [+ 2 isozymes] [+ 9 isozymes] asp synthase: AMP cyclohydrolase: L-glutamate-5- ser hydrolase: GLX2-1 dehydrogenase: citrate synthase: asparagine carbamoyl- AT2G29690.1 AT1G31860.1 asp synthase (glutamine- L-ornithine N-acetyl-L-ornithine arg semialdehyde hydroxyacylglutathione AT3G23940.1 AT2G44350.2 prephenate β dihydroxyacid phosphate anthranilate 1-(5-phospho- -D-ribosyl)- asparaginase: hydrolyzing): ASN3 ornithine-δ- hydrolase: GLX2-5 acetol aspartate kinase: citrate synthase: 5-[(5-phosphoribosylamino) dehydrogenase: arogenate arogenate synthase: AT4G00590.1 asparagine met dehydrogenase: dehydratase: arginase: ARGAH1 aminotransferase: serine racemase: (S)-1-pyrroline- AK-HSDH2 3-methyl-2- AT3G58750.1 methylideneamino]imidazole- aspartate kinase: AT3G23940.1 δ citrate synthase: AT2G44350.2 citrate synthase: AT1G25220.2 prephenate asparaginase: synthase (glutamine- AT1G15710.1 AT1G08250.1 arginase: ARGAH2 -OAT AT4G11640.1 5-carboxylate (R)-lactate aspartate kinase: 2-oxobutanoate oxobutanoate [+ 6 isozymes] aminotransferase: 4-carboxamide 3-hydroxypropanoyl- AK-HSDH2 [+ 3 isozymes] D-myo-inositol AT2G42790.1 phosphoribosyl-formimino- AT5G08100.1 hydrolyzing): ASN2 3-methyl-2- AT3G49680.1: arogenate arogenate malate dehydrogenase (NAD) AT3G02020.1 AT2G22250.2 CoA aspartate kinase: ornithine D-myo-inositol (1,2,3) trisphosphate [+ 3 isozymes] 5-aminoimidazole- asparaginase: asparagine 2-oxobutanoate oxobutanoate Atbcat-3 dehydrogenase: dehydratase: pyrroline-5- malate dehydrogenase (1,2,6) trisphosphate aspartate kinase: AT3G02020.1 AT3G16150.1 D-lactate acetolactate 4-carboxamide synthase (glutamine- carbamoyltransferase methionine-oxo- AT5G34930.1 AT3G44720.1 carboxylate malate dehydrogenase: cyMDH AK-HSDH1 2-isopropylmalate branched-chain aspartate kinase: ornithine D-serine dehydrogenase: synthase: anthranilate ribonucleotide 3-cyano-L-alaninehydrolyzing): ASN1 hypusine acid transaminase: arogenate reductase: P5C1 fumarate hydratase: FUM1 malate dehydrogenase (NAD): cMDH [+ 2 isozymes] synthase: MAM3 amino acid citrate L-arogenate AK-HSDH1 branched-chain carbamoyltransferase: GDH (S)-propane-1,2-diol AT3G48560.1 2-isopropylmalate isomerase: AT2G36230.1 nitrilase: NIT4 asparagine synthase acetolactate amino acid biosynthesis AT3G19710.1 dehydratase: fumarase: FUM2 malate dehydrogenase: mMDH1 aminotransferase: [+ 2 isozymes] OTC L-ornithine synthase: MAM1 anthranilate (glutamine-hydrolysing) synthase: aminotransferase: [+ 2 isozymes] AT2G27820.1 [+ 6 isozymes] L-aspartyl- Atbcat-3 : AT2G03667.1 tyr pyruvate (S)-2-aceto-2- 2-isopropylmalate aconitate hydratase: phosphoribosyltransferase: superpathway of lysine, threonine and methionine biosynthesis II phosphoribulosylformimino- AT3G48560.1 Atbcat-3 arogenate AT4G11640.1: pro fumarate citrate 4-phosphate branched-chain AT5G54950.1 arogenate L-aspartyl- 2-oxo-4- dehydratase: hydroxybutanoate synthase: IPMS1 AT1G70570.2 arogenate AICAR-P 3-hydroxypropanoate branched-chain spermidine N-acetyltransferase: AT4G11640.1 amino acid aconitase: ACO3 dehydrogenase: dehydratase: 4-phosphate methylthiobutanoate AT3G07630.1 2-isopropylmalate anthranilate asn (S)-2-aceto-2- amino acid AT2G39020.1 δ succinate:ubiquinone oxidoreductase: D-sorbitol aminotransferase: AT1G08250.1 Ins(1,2)P 2 aspartate synthase: IPMS2 aconitase: ACO2 phosphoribosyltransferase: AT1G15710.1 hydroxybutanoate aminotransferase: arogenate ornithine N - SDH1-1 SDH2-2 SDH3-2 SDH4 degradation I semialdehyde Atbcat-2 aconitase: ACO1 arogenate arogenate imidazoleglycerolphosphate aspartate L-citrulline methylthioalkylmalate dehydratase: 2-aminoprop- branched-chain- AT5G17990.1 asp Atbcat-2 AT5G05920: acetyltransferase: SDH5 SDH6 SDH7A SDH8 SDH7B dehydrogenase: dehydrogenase: dehydratase: synthase: AT4G26900.1 semialdehyde synthase: MAM3 AT1G11790.1 2-enoate amino-acid branched-chain- AT5G05920.1 AT2G39030.1 succinate dehydrogenase aconitate hydratase: AT5G54950.1 AT1G14810.1 cis-aconitate N-(5-phosphoribosyl) AT5G34930.1 AT3G44720.1 dehydrogenase: methylthioalkylmalate arogenate D-sorbitol (2S)-2- aspartate kinase: amino-acid δ (ubiquinone): SDH7B aconitase: ACO3 transaminase: -anthranilate arogenate AT1G14810.1 argininosuccinate synthase: MAM1 dehydratase: oxaloacetate (R)-2,3-dihydroxy- isopropylmalate Atbact-5 AK-HSDH2 transaminase: L-N -acetylornithine succinate dehydrogenase aconitase: ACO2 L-aspartate- dehydratase: synthase: methylthioalkylmalate AT5G22630.1 3-methylpentanoate [+ 2 isozymes] phosphoribosylanthranilate AICAR D-erythro-imidazole- malonate Atbact-5 dehydrospermidine (ubiquinone): SDH7A aconitase: ACO1 L-iditol 2- semialdehyde 3-isopropylmalate aconitate hydratase: AT2G27820.1 aspartate