US00859 1874B2 (12) United States Patent (10) Patent No.: US 8.591,874 B2 Oblong et al. (45) Date of Patent: Nov. 26, 2013 (54) INHIBITION OF MAMMALIAN HAIR 4,628,078 A 12/1986 Glover et al. GROWTH 4,708,966 A 11, 1987 Loomans et al. 4,797,300 A 1/1989 Jandacek et al. 4,835,148 A 5/1989 Barford et al. (75) Inventors: John Erich Oblong, oveland, OH 4,835,206 A 5/1989 Farrar et al. (US); Sara Johnson McPhail, West 4,847,071. A 7/1989 Bissett et al. Chester, OH (US); Shannon Christine 4,849,484 A 7/1989 Heard McArthur, Indian Springs, OH (US); 4,937,370 A 6/1990 Sabatelli Charles Carson Bascom, Hamilton, OH 4,960,764 A 10/1990 Figueroa, Jr. et al. 4,976,953. A 12/1990 Orr et al. (US); David Joseph Eickhoff, Ft. 4,999,186 A 3/1991 Sabatelli et al. Mitchell, KY (US); John McMillan 5,004,734 A 4/1991 Philippe McIver, Cincinnati, OH (US) 5,011,681 A 4, 1991 Ciotti et al. 5,073,371 A 12/1991 Turner et al. (73) Assignee: This Prote Sable Company, 5,087.4455,073.372 A 12/19912/1992 TurnerHaffey et al. incinnati, OH (US) 5,100,660 A 3/1992 Hawe et al. - 5, 120,532 A 6/1992 Wells et al. (*) Notice: Subject to any disclaimer, the term of this 5,151,209 A 9, 1992 McCall et al. patent is extended or adjusted under 35 5,151,210 A 9, 1992 Steuri et al. U.S.C. 154(b) by 0 days. 5,189,066 A 2f1993 Kelmet al. 5,204,093 A 4, 1993 Victor 5,280,045 A 1/1994 Dobson et al. (21) Appl. No.: 11/344,771 5,306,515 A 4, 1994 Letton et al. 5,306,516 A 4, 1994 Letton et al. (22) Filed: Feb. 1, 2006 (Continued) (65) Prior Publication Data FOREIGN PATENT DOCUMENTS US 2006/O127431 A1 Jun. 15, 2006 EP O228868 A2 7, 1987 Related U.S. ApplicationO O Data EP O330369 A1 8, 1989 (Continued) (63) Continuation of application No. 10/783,151, filed on Feb. 19, 2004, now abandoned. OTHER PUBLICATIONS (60) Provisional application No. 60/451,910, filed on Mar. Agmatine structure, from Sigma. 4, 2003. Paus et al. “The Biology of Hair Follicles': Mechanism of Diseases, vol. 341, No. 7, pp. 491-497, Aug. 12, 1999.* (51) Int. Cl. Agmatine structure, from Sigma. Downlaoded on Oct. 28, 2008, A6 IK 8/73 (2006.01) previously provided.* A6 IK 8/00 (2006.01) US 5,674.447, 10/1997, Ahluwalia (withdrawn). A61O5/00 (2006.01) US 5.305.514, 04/1994, Letton et al. (withdrawn). A61O 9/00 (2006.01) Continued (52) U.S. Cl. (Continued) USPC ....................................... 424/70.17; 424/70.1 (58) Field of Classification Search Primary Examiner — Isis Ghali None (74) Attorney, Agent, or Firm — John G. Powell; Angela K. See application file for complete search history. Haughey; Melody A. Jones (56) References Cited (57) ABSTRACT U.S. PATENT DOCUMENTS The present invention relates to a topical skin care composi 2,798,053 A 7, 1957 Brown tion containing a safe and effective amount of a skin care 3. A E. E" et al. active comprising agmatine, and its salt; a safe and effective s 5 5. 560 A 8, 1973 Dickert et al. amount of a first additional skin care active selected from the 3,929,678 A 12/1975 Laughlin et al. group consisting of BHT or BHA, hexamidine, cetyl pyri 3,959,461 A 5/1976 Bailey et al. dinium chloride, green tea catechins, phytosterols, ursolic 3,963,699 A 6, 1976 RiZZi et al. acid, compounds derived from plant extracts, their salts and 28:8. A 22, ania et al. derivatives; and a dermatologically acceptable carrier for the 4206.21 5 A 6/1980 Bailey agmatine composition. The present invention also relates to 4,387,090 A 6/1983 Bolich, Jr. methods of using Suchagmatine compositions to regulate hair 4.421,769 A 12/1983 Dixon et al. growth and the condition of mammalian skin. The methods 4,505,924 A ck 3/1985 Taylor generally comprise the step of topically applying the compo 235 A 38. Rail, r 514f673 sition to the skin of a mammal needing such treatment, a safe 45 17360 A 5/1985 Volpenhein and effective amount of such compositions. 4,518,772 A 5/1985 Volpenhein 4,557,853. A 12/1985 Collins 4,599,379 A 7, 1986 Flesher et al. 5 Claims, No Drawings US 8,591,874 B2 Page 2 (56) References Cited WO WO-91 (16034 A1 10, 1991 WO WO-91 (16035 A1 10, 1991 U.S. PATENT DOCUMENTS WO WO-95/13048 A1 5, 1995 WO WO-95/23780 A2 9, 1995 5,476,876 A 12/1995 Pikul et al. WO WO-95/3428O A1 12, 1995 5.487,884 A 1/1996 Bissett et al. WO WO-96,01101 A1 1, 1996 5,510,361. A 4, 1996 Scherz et al. WO WO96,26705 A1 9, 1996 5,554,608 A 9, 1996 Ahluwalia WO WO97, 19672 A1 6, 1997 5,607.980 A 3/1997 McAtee et al. WO WO-97,397.33 A1 10, 1997 5,652,228 A 7/1997 Bissett WO WO-99/37277 7, 1999 5,674,477 A 10/1997 Ahluwalia WO WOO1/43717 A1 6, 2001 5,681,852 A 10/1997 Bissett WO O3O92668 5, 2002 5,684,204 A 1 1/1997 Matthews et al. 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A &2.99 SCE Carlotti et al., “Optimization of W/O-S Emulsions and Study of the 6.1 49.896 A * 11, 2000 Riklis et al, . 424,59 Quantitative Relationships between Ester Structure and Emulsion 6,207,596 B1 3, 2001 Rourke Properties,” J. Dispersion Science and Technology, 13(3), pp. 315 6,375,948 B1 4/2002 Tsuji 336 (1992). 6,495,149 B1 12/2002 Scavone et al. Hameyer, P. "Comparative Technological Investigations of Organic 6,716,414 B2 4/2004 Lewis et al. ..................... 424/45 and Organosilicone Emulsifiers in Cosmetic Water-in-Oil Emulsion 6,716,441 B1 4/2004 Osborne Preparations.” HAPPI 28 (4), pp. 88,90,92, and 94 (Apr. 1991). 2003/01 18539 A1* 6/2003 Fahl et al. .................. 424.70.17 Smid-Korbaret al., “Efficiency and Usability of Silicone Surfactants 2003. O165447 A1 9, 2003 Scavone et al. in Emulsions.” Provisional Communication, International Journal of 2003. O190337 A1 10, 2003 Bissett Cosmetic Science, vol. 12, No. 3, 135-139 (Jun. 1990). 2005.0003024 A1 1/2005 Oblong et al. Krzysik et al., “A New Silicone Emulsifier for Water-in-Oil Sys 2008/01885052006, O127431 A1 8/20086/2006 Oblong tems.” DrugD anddC Cosmetic tic IndIndustry, vol.1. 146 (4),(4 pp. 28-35.79, 9 anand 81 (Apr. 1990). CTFA International Cosmetic Ingredient Dictionary, Fourth Edition, FOREIGN PATENT DOCUMENTS pp. 12 and 80 (1991). JP 632O3608 8, 1988 Sagarin, Cosmetics, Science and Technology, 2nd Edition, vol. 1, pp. JP 11-035425 2, 1999 72-73 (1972). JP 11-322548 11, 1999 The Merck Index, Tenth Edition, entry 3167, p. 463 (1983). JP 2000-302659 10, 2000 U.S. Appl. No. 08/570,275, filed Dec. 11, 1995, Zukowski et al. JP 2000-319154 11, 2000 JP 2002-24.9414 9, 2002 * cited by examiner US 8,591,874 B2 1. 2 INHIBITION OF MAMMALIAN HAIR possible birth defect implications. Since in non-hirsutistic GROWTH females, the role of androgens is not required for normal hair growth, there is a need for technologies that do not function CROSS REFERENCE TO RELATED via androgen mediated pathways due to the birth defect impli APPLICATION(S) cations. Depilatory devices can be painful to use and are not well-suited for many areas of the body including underarms This application is a continuation of U.S. application Ser. and face. Finally, depilatory creams, although effective, are No. 10/783,151, filed on Feb. 19, 2004 now abandoned; messy to apply and typically are not recommended for fre which claims the benefit of U.S. Provisional Application Ser. quent use due to their high irritancy potential. No. 60/451,910, filed Mar. 4, 2003. 10 Therefore, a need exists for a safe, effective way to not only regulate the condition of mammalian keratinous tissue, but TECHNICAL FIELD also to retard, inhibit, and/or stop unwanted mammalian hair The present invention relates to topical compositions con growth on designated areas of the body.