Supplemental Table 1 Genes up-regulated (>2.0) in Stat3∆/∆ compared with Stat3flox/flox Probe ID Gene Symbol Gene Description Entrez gene ID 1460470_at Acoxl acyl-Coenzyme A oxidase-like 74121 1459876_at --- --- --- 1459875_x_at 5730494M16Rik RIKEN cDNA 5730494M16 gene 66648 1459841_x_at Laptm5 lysosomal-associated protein transmembrane 5 16792 1459118_at D230038C21 hypothetical protein D230038C21 328872 1459018_at D10Ertd447e DNA segment, Chr 10, ERATO Doi 447, expressed 52607 1458924_at D430013B06Rik RIKEN cDNA D430013B06 gene 399594 1458729_at --- --- --- 1458712_at --- --- --- 1458274_at Zfp69 zinc finger protein 69 381549 1457966_at --- --- --- 1457851_at --- --- --- 1457743_at --- --- --- 1457633_x_at Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 12862 1457589_at Fat3 FAT tumor suppressor homolog 3 (Drosophila) 270120 1457491_at Plekha1 Pleckstrin homology domain containing, family A (phosphoinositide binding 101476 specific) member 1 1457332_at Prmt3 protein arginine N-methyltransferase 3 71974 1457247_at Lmln leishmanolysin-like (metallopeptidase M8 family) 239833 1457129_at LOC100504796 hypothetical LOC100504796 100504796 1456854_at Neurl1a neuralized homolog 1A (Drosophila) 18011 1456794_at E230016M11Rik RIKEN cDNA E230016M11 gene 320172 1456793_at Cytl1 cytokine-like 1 231162 1456780_at --- --- --- 1456527_at Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 94253 1456418_at Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 100040591 1456404_at Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin 23794 type 1 motif, 5 (aggrecanase-2) 1456402_at A330076H08Rik RIKEN cDNA A330076H08 gene 320026 1455999_at Cphx cytoplasmic polyadenylated homeobox 105594 1455784_at Sec1 secretory blood group 1 56546 1455627_at Col8a1 collagen, type VIII, alpha 1 12837 1455521_at Klf12 Kruppel-like factor 12 16597 1455445_at Cbln3 cerebellin 3 precursor protein 56410 1455074_at Efcab1 EF hand calcium binding domain 1 66793 1454871_at Rbm15b RNA binding motif protein 15B 109095 1454303_at Epn2 epsin 2 13855 1454299_at 4833422B07Rik RIKEN cDNA 4833422B07 gene 74587 1454123_at 4933406K04Rik RIKEN cDNA 4933406K04 gene 71033 1453854_at Ptar1 protein prenyltransferase alpha subunit repeat containing 1 72351 1453593_at Vgll3 vestigial like 3 (Drosophila) 73569 1453523_at Krtap17-1 keratin associated protein 17-1 77914 1453487_at Dhdh dihydrodiol dehydrogenase (dimeric) 71755 1453215_at Rnase10 ribonuclease, RNase A family, 10 (non-active) 75019 1453152_at Mamdc2 MAM domain containing 2 71738 1453083_at Vmn2r29 vomeronasal 2, receptor 29 76229 1452968_at Cthrc1 collagen triple helix repeat containing 1 68588 1452855_at Ly6k lymphocyte antigen 6 complex, locus K 76486 1452815_at P2ry10 purinergic receptor P2Y, G-protein coupled 10 78826 1447948_at A430107O13Rik RIKEN cDNA A430107O13 gene 214642 1447891_at --- --- --- 1447708_x_at Pde2a phosphodiesterase 2A, cGMP-stimulated 207728 1447683_x_at Mettl1 methyltransferase like 1 17299 1447643_x_at Snai2 snail homolog 2 (Drosophila) 20583 1447341_at --- --- --- 1447252_s_at Mep1a meprin 1 alpha 17287 1447240_at --- --- --- 1447046_at Ucp2 Uncoupling protein 2 (mitochondrial, proton carrier) 22228 1446968_at Picalm phosphatidylinositol binding clathrin assembly protein 233489 1446846_at --- --- --- 1446331_at Ptgfr prostaglandin F receptor 19220 1446291_at Vipar VPS33B interacting protein, apical-basolateral polarity regulator 104799 1446129_at --- --- --- 1446102_at D9Ertd292e DNA segment, Chr 9, ERATO Doi 292, expressed 52208 1445918_at Tmem2 Transmembrane protein 2 83921 1445562_at --- --- --- 1445531_at Csmd1 CUB and Sushi multiple domains 1 94109 1445421_at --- --- --- 1445097_at --- --- --- 1444644_x_at Tatdn1 TatD DNase domain containing 1 69694 1444518_at Acox1 Acyl-Coenzyme A oxidase 1, palmitoyl 11430 1444465_at Ube4b Ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 63958 1444288_at Pnpt1 polyribonucleotide nucleotidyltransferase 1 71701 1444256_at Rae1 RAE1 RNA export 1 homolog (S. pombe) 66679 1444152_at Celf2 CUGBP, Elav-like family member 2 14007 1444057_at --- --- --- 1443988_at Rbm39 RNA binding motif protein 39 170791 1443984_at Lin9 lin-9 homolog (C. elegans) 72568 1443931_at Zfp882 zinc finger protein 882 382019 1443832_s_at Sdpr serum deprivation response 20324 1443782_x_at Cyp20a1 cytochrome P450, family 20, subfamily A, polypeptide 1 77951 1443768_at Rhoa Ras homolog gene family, member A 11848 1443657_at Fhdc1 FH2 domain containing 1 229474 1443539_at Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 213498 1443467_at Dock11 dedicator of cytokinesis 11 75974 1443302_at 6720403M19Rik RIKEN cDNA 6720403M19 gene 320619 1443262_at Mrps14 mitochondrial ribosomal protein S14 64659 1443249_at --- --- --- 1443230_at --- --- --- 1443137_at --- --- --- 1443087_at Cdc23 CDC23 (cell division cycle 23, yeast, homolog) 52563 1443007_at --- --- --- 1442880_at --- --- --- 1442629_at --- --- --- 1442556_at --- --- --- 1442351_a_at BC029214 cDNA sequence BC029214 227622 1442305_at Gtpbp2 GTP binding protein 2 56055 1442292_at Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 73341 1442175_at C030027H14Rik /// Srgap1 RIKEN cDNA C030027H14 gene /// SLIT-ROBO Rho GTPase activating protein 1 117600 /// 77465 1442115_at Fam38b family with sequence similarity 38, member B 667742 1442041_at LOC552876 hypothetical LOC552876 552876 1441954_s_at H1fnt H1 histone family, member N, testis-specific 70069 1441899_x_at Bcan brevican 12032 1441857_x_at Seh1l SEH1-like (S. cerevisiae 72124 1441799_at 6030422H21Rik RIKEN cDNA 6030422H21 gene 402765 1441416_at Inpp4b inositol polyphosphate-4-phosphatase, type II 234515 1441150_x_at Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 67742 1441101_at Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 94253 1440919_at Mobkl2c MOB1, Mps One Binder kinase activator-like 2C (yeast) 100465 1440685_at --- --- --- 1440441_at Fbxl7 F-box and leucine-rich repeat protein 7 448987 1440286_at Fbxl16 F-box and leucine-rich repeat protein 16 214931 1440205_at Zmynd19 zinc finger, MYND domain containing 19 67187 1440156_s_at Tox2 TOX high mobility group box family member 2 269389 1440087_at --- --- --- 1439950_at Dync1h1 dynein cytoplasmic 1 heavy chain 1 13424 1439794_at Ntn4 netrin 4 57764 1439768_x_at Sema4f sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic 20355 domain 1439665_at Lpar4 lysophosphatidic acid receptor 4 78134 1439478_at Acot2 acyl-CoA thioesterase 2 171210 1439265_at --- --- --- 1439131_at Txlng taxilin gamma 353170 1439127_at AI314180 expressed sequence AI314180 230249 1439053_at D10Bwg1070e DNA segment, Chr 10, Brigham & Women's Genetics 1070 expressed 52902 1438614_x_at Osbpl9 oxysterol binding protein-like 9 100273 1438576_x_at --- --- --- 1438301_at --- --- --- 1438239_at Mid1 midline 1 17318 1438081_at Mcc mutated in colorectal cancers 328949 1437759_at Pfkp Phosphofructokinase, platelet 56421 1437559_at Rgs7bp regulator of G-protein signalling 7 binding protein 52882 1437482_at Tecrl trans-2,3-enoyl-CoA reductase-like 243078 1437479_x_at Tbx3 T-box 3 21386 1437260_at Mmrn1 multimerin 1 70945 1436830_at Marveld1 MARVEL (membrane-associating) domain containing 1 277010 1436786_at 1110069O07Rik RIKEN cDNA 1110069O07 gene 71798 -> 380683 1436659_at Dclk1 doublecortin-like kinase 1 13175 1436614_at --- --- --- 1436503_at BC048546 cDNA sequence BC048546 232400 1436502_at Mtus1 mitochondrial tumor suppressor 1 102103 1436218_at Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 329252 1436155_at Nmnat2 nicotinamide nucleotide adenylyltransferase 2 226518 1436044_at Scn7a sodium channel, voltage-gated, type VII, alpha 20272 1436043_at Scn7a sodium channel, voltage-gated, type VII, alpha 20272 1435701_at Cyyr1 cysteine and tyrosine-rich protein 1 224405 1435640_x_at A130040M12Rik RIKEN cDNA A130040M12 gene 319269 1435471_at Zfp708 zinc finger protein 708 432769 1435354_at Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 16516 1435351_at Bend5 BEN domain containing 5 67621 1435261_at Tmtc1 transmembrane and tetratricopeptide repeat containing 1 387314 1435204_at Prmt8 protein arginine N-methyltransferase 8 381813 1434639_at Klhl29 kelch-like 29 (Drosophila) 208439 1434458_at Fst follistatin 14313 1434186_at Lpar4 lysophosphatidic acid receptor 4 78134 1434141_at Gucy1a3 guanylate cyclase 1, soluble, alpha 3 60596 1433914_at Lipo1 lipase, member O1 381236 1433716_x_at Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 14586 1433600_at Adra2a adrenergic receptor, alpha 2a 11551 1432631_at Prrc1 proline-rich coiled-coil 1 73137 1432356_at 1700056N10Rik RIKEN cDNA 1700056N10 gene 73392 1432217_a_at Wdr16 WD repeat domain 16 71860 1431970_at Tm7sf4 transmembrane 7 superfamily member 4 75766 1431788_at Fabp12 fatty acid binding protein 12 75497 1430852_at 1600029I14Rik RIKEN cDNA 1600029I14 gene 69797 1430557_at 4930434J08Rik RIKEN cDNA 4930434J08 gene 73979 1430498_at 9130009I01Rik RIKEN cDNA 9130009I01 gene 71594 1430367_at Stambpl1 STAM binding protein like 1 76630 1430296_at Krtap31-1 keratin associated protein 31-1 70831 1429767_at 2810013P06Rik RIKEN cDNA 2810013P06 gene 67206 1429751_at Zswim2 zinc finger, SWIM domain containing 2 71861 1428909_at A130040M12Rik RIKEN cDNA A130040M12 gene 319269 1420294_at --- --- --- 1420154_at --- --- --- 1460699_at Rps27 ribosomal protein S27 57294 1460407_at Spib Spi-B transcription factor (Spi-1/PU.1 related)