IMPACT FACTOR 5.923 an Open Access Journal by MDPI ALE 2022: Adaptive Laboratory Evolution—a Natural Path to Artificial Biology Guest Editor: Message from the Guest Editor Prof. Dr. Nediljko Budisa Synthetic biology, as the most advanced form of (1) Department of Chemistry, bioengineering, views living cells as small programmable University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada production units with DNA as the soware that defines the (2) Institute of Biotechnology, production of proteins and other small metabolites and Technical University of Berlin, macromolecules that can be considered as their hardware. Gustav-Meyer-Allee 25 , D-13355 The ultimate goal of synthetic biology is to reprogram the Berlin, Germany soware of life and create synthetic organisms as [email protected] production platforms for virtually any conceivable substance of medical or industrial interest. In this way, the production of synthetic cells will itself become a major Deadline for manuscript technology of the 21st century. submissions: 31 December 2021 In the coming decade, ALE should lead to the development of biocontained microbial strains that are extremely important to emerging environmental biosafety and biosecurity problems. As they depend on the exclusive presence of xenobiotic nutrients for survival and reproduction, the microbial strains that are developed will be the best platforms for creating fully synthetic life. mdpi.com/si/83028 SpeciaIslsue IMPACT FACTOR 5.923 an Open Access Journal by MDPI Editor-in-Chief Message from the Editor-in-Chief Prof. Dr. Maurizio Battino The International Journal of Molecular Sciences (IJMS, 1. Department of ISSN 1422-0067) is an open access journal, which was Odontostomatologic and established in 2000. The journal aims to provide a forum Specialized Clinical Sciences, Sez-Biochimica, Faculty of for scholarly research on a range of topics, including Medicine, Università Politecnica biochemistry, molecular and cell biology, molecular delle Marche, Via Ranieri 65, biophysics, molecular medicine, and all aspects of 60100 Ancona, Italy molecular research in chemistry. IJMS publishes both 2. International Research Center for Food Nutrition and Safety, original research and review articles, and regularly Jiangsu University, Zhenjiang publishes special issues to highlight advances at the 212013, China cutting edge of research. We invite you to read recent articles published in IJMS and consider publishing your next paper with us. Author Benefits Open Access:— free for readers, with article processing charges (APC) paid by authors or their institutions. High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, PMC, MEDLINE, Embase, CAPlus / SciFinder, and many other databases. Journal Rank: JCR - Q1 (Biochemistry & Molecular Biology) / CiteScore - Q1 (Inorganic Chemistry) Contact Us International Journal of Molecular Tel: +41 61 683 77 34 mdpi.com/journal/ijms Sciences Fax: +41 61 302 89 18 [email protected] MDPI, St. Alban-Anlage 66 www.mdpi.com @IJMS_MDPI 4052 Basel, Switzerland.