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Find out more on how ISSN 1664-8714 to host your own Frontiers Research Topic or contribute to one as an author by ISBN 978-2-88963-055-4 DOI 10.3389/978-2-88963-055-4 contacting the Frontiers Editorial Office: [email protected] Frontiers in Psychiatry 1 November 2019 | Cognitive Enhancement in Psychiatric Disorders COGNITIVE ENHANCEMENT IN PSYCHIATRIC DISORDERS Topic Editors: Tomiki Sumiyoshi, National Center of Neurology and Psychiatry, Japan Kenji Hashimoto, Chiba University, Japan Image: Cognitive Health “To overcome cognitive difficulties brings about peace of mind”. Scenes photographed by Tomiki Sumiyoshi Disturbances of various domains of cognitive function have been shown to provide a major determinant of outcome for patients with psychiatric conditions. Cognitive impairment is present in an array of diseases, including schizophrenia (with its prodromal stage), mood disorder, autism spectrum disorder, obsessive-compulsive disorder, anxiety disorder, post-traumatic disorder, and eating disorder. In an effort to develop effective therapeutics for cognitive impairment, bridging of preclinical and clinical evidence has been attempted. Frontiers in Psychiatry 2 November 2019 | Cognitive Enhancement in Psychiatric Disorders This edited Book will provide a forum for researchers and clinicians interested in the phenomenology, underlying mechanisms, and treatment of cognitive impairment associated with psychiatric illnesses. Twenty-eight contributions from 8 countries in Europe, Middle East, Asia, North America, and South America represent studies dealing with genetic, molecular, imaging, physiological, psychological, and behavioral issues. Information in this Book will facilitate the development of therapeutics of greater clinical value. Citation: Sumiyoshi, T., Hashimoto, K., eds. (2019). Cognitive Enhancement in Psychiatric Disorders. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88963-055-4 Frontiers in Psychiatry 3 November 2019 | Cognitive Enhancement in Psychiatric Disorders Table of Contents 07 Editorial: Cognitive Enhancement in Psychiatric Disorders Tomiki Sumiyoshi and Kenji Hashimoto NEUROBIOLOGY OF COGNITIVE IMPAIRMENTS 10 Genetic Biomarkers on Age-Related Cognitive Decline Chieh-Hsin Lin, Eugene Lin and Hsien-Yuan Lane 19 Right Frontotemporal Cortex Mediates the Relationship Between Cognitive Insight and Subjective Quality of Life in Patients With Schizophrenia Shenghong Pu, Kazuyuki Nakagome, Masashi Itakura, Hiroaki Ohtachi, Masaaki Iwata, Izumi Nagata and Koichi Kaneko 29 Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies Harumasa Takano 37 Electrophysiological Evidence in Schizophrenia in Relation to Treatment Response Kazuki Sueyoshi and Tomiki Sumiyoshi 43 Sensorimotor Gating in Depressed and Euthymic Patients With Bipolar Disorder: Analysis on Prepulse Inhibition of Acoustic Startle Response Stratified by Gender and State Junko Matsuo, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi and Hiroshi Kunugi 55 Relationship of Handgrip Strength and Body Mass Index With Cognitive Function in Patients With Schizophrenia Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Miho Ota, Kotaro Hattori and Hiroshi Kunugi 66 Early Intervention and a Direction of Novel Therapeutics for the Improvement of Functional Outcomes in Schizophrenia: A Selective Review Masayoshi Kurachi, Tsutomu Takahashi, Tomiki Sumiyoshi, Takashi Uehara and Michio Suzuki EVALUATION OF COGNITIVE DISTURBANCES AND RELATED ISSUES 77 Semantic Memory Organization in Japanese Patients With Schizophrenia Examined With Category Fluency Chika Sumiyoshi, Haruo Fujino, Tomiki Sumiyoshi, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto and Ryota Hashimoto 87 Neuropsychological Profile of Specific Executive Dysfunctions in Patients With Deficit and Non-deficit Schizophrenia Ernest Tyburski, Justyna Pełka-Wysiecka, Monika Mak, Agnieszka Samochowiec, Przemysław Bieńkowski and Jerzy Samochowiec Frontiers in Psychiatry 4 November 2019 | Cognitive Enhancement in Psychiatric Disorders 97 A Brief Assessment of Intelligence Decline in Schizophrenia as Represented by the Difference Between Current and Premorbid Intellectual Quotient Kazutaka Ohi, Chika Sumiyoshi, Haruo Fujino, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Tomiki Sumiyoshi and Ryota Hashimoto 107 Verbal Memory Impairment in Patients With Subsyndromal Bipolar Disorder Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi and Kazuyuki Nakagome 114 Competence to Consent and its Relationship With Cognitive Function in Patients With Schizophrenia Norio Sugawara, Norio Yasui-Furukori and Tomiki Sumiyoshi PHARMACOLOGIC STRATEGIES TO AMELIORATE COGNITIVE IMPAIRMENTS 119 Medications Used for Cognitive Enhancement in Patients With Schizophrenia, Bipolar Disorder, Alzheimer’s Disease, and Parkinson’s Disease Wen-Yu Hsu, Hsien-Yuan Lane and Chieh-Hsin Lin 130 Effects of Continuing Oral Risperidone vs. Switching From Risperidone to Risperidone Long-Acting Injection on Cognitive Function in Stable Schizophrenia Patients: A Pilot Study Hikaru Hori, Asuka Katsuki, Kiyokazu Atake and Reiji Yoshimura 134 Potential and Challenges for the Clinical Use of D-Serine as a Cognitive Enhancer Gerson D. Guercio and Rogerio Panizzutti 144 Drugs Interfering With Muscarinic Acetylcholine