MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS MAGDEBURG Report 2019 – 2020 g Frania Zuñiga Ph.D. candidate in the Bioprocess Engineering group With a focus on proteomics, glycomics and glycoproteomics, the Bio/Process Analytics team is developing a comprehensive set of bioanalytical tools for the in-depth analysis of protein expression and post-translational modifications of proteins, such as glycosylation. Glycosylation is the biological process of creating a sugar chain (glycan) attached to proteins. Even though it is so far unpredictable, the glycan composition can reflect the cellular homeostasis. In the Report picture, Frania Zuñiga inspects the inner structure of the MALDI- TOF (matrix-assisted laser desorption/ionization-time of flight) mass spectrometer. This instrument is capable to accurately measure the molecular mass of both free glycans and glycans attached to small 2019 – 2020 fragments of proteins. The molecular mass is a powerful evidence for supporting the identification and validation of novel glycan MAX PLANCK INSTITUTE compositions. FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS MAGDEBURG FREQUENTLY USED ABBREVIATIONS Research Groups headed by MPI Directors DFG German Science Foundation BPE Bioprocess Engineering (Deutsche Forschungsgemeinschaft) CSC Computational Methods in Systems and Control Theory FVST Faculty of Process and Systems Engineering PCF Physical and Chemical Foundations of Process Engineering at OVGU Magdeburg PSE Process Systems Engineering GAMM International Association of Applied Mathematics and Mechanics (Gesellschaft für Angewandte Mathematik und Mechanik) Research Groups headed by External Scientific Members IMPRS International Max Planck Research School PSD Process Synthesis and Dynamics LSA German Federal State of Saxony-Anhalt MLU Martin Luther University Halle-Wittenberg Research Groups headed by Senior Scientists MPG Max Planck Society (Max-Planck-Gesellschaft) ARB Analysis and Redesign of Biological Networks MPI Max Planck Institute for Dynamics of Complex Technical Systems EEC Electrochemical Energy Conversion Magdeburg MSD Molecular Simulations and Design Omics Various disciplines in biology whose names end in the suffix -omics, such as genomics, proteomics, metabolomics and Max Planck Fellow Group glycomics DRI Data-Driven System Reduction and Identification OVGU Otto von Guericke University Magdeburg SAB Scientific Advisory Board Others SFB CRC TRR DFG-funded Transregional Collaborative Research Center ATP Adenosine triphosphate, organic compound (Sonderforschungsbereich) that provides energy to drive many processes in living cells SIAM Society for Industrial and Applied Mathematics BMBF German Federal Ministry of Education and Research TH University of Applied Sciences (Technische Hochschule) BMWi German Federal Ministry for Economic Affairs and Energy TU Technical University (Technische Universität Berlin, CDS Center for Dynamic Systems: Biosystems Engineering Technische Universität Dortmund) (Magdeburg) UNRAVEL European project: A Unique Refinery Approach CORE European project: Continuous Resolution and to Valorise European Lignocellulosis Deracemization of Chiral Compounds by Crystallization COST European Cooperation in Science and Technology CPTS Chemistry, Physics and Technology Section of MPG DAAD German Academic Exchange Service DARPA Defense Advanced Research Projects Agency (United States) DECHEMA Expert Network for Chemical Engineering and Biotechnology in Germany (Gesellschaft für Chemische Technik und Biotechnologie e.V.) ERC European Research Council ERDF European Regional Development Fund (Europäischer Fonds für regionale Entwicklung (EFRE) EXIST University-Based Business Start-Ups (support programme of the BMWi) 4 TABLE OF CONTENTS 5 g Research Groups BPE 22 DRI 50 ARB 54 CSC 28 PCF 34 MSD 58 EEC 62 g Download as PDF: www.mpi-magdeburg.mpg.de/mpi_annual_report 34 PCF Senior Scientists PSE 40 PSD 46 PHYSICAL AND CHEMICAL FOUNDATIONS OF PROCESS ENGINEERING 54 ARB Prof. Dr.-Ing. Andreas Seidel-Morgenstern ANALYSIS AND REDESIGN OF BIOLOGICAL NETWORKS 40 PSE Dr.-Ing. Steffen Klamt Introduction Research Groups PROCESS SYSTEMS ENGINEERING Prof. Dr.-Ing. Kai Sundmacher 58 MSD 6 Preface by Prof. Kurt Wagemann Directors MOLECULAR SIMULATIONS AND DESIGN Dr. Matthias Stein 8 Milestones of our Max Planck Institute 20 INTERDISCIPLINARY PROJECT: External Scientific Members in 2019 and 2020 Integrated Process Design for Fine and Max Planck Fellows 62 EEC Chemicals from Renewable Feedstocks ELECTROCHEMICAL ENERGY CONVERSION 12 Facts and Figures 46 PSD Dr.-Ing. Tanja Vidakovic´-Koch 22 BPE PROCESS SYNTHESIS AND 14 Selected Events 2019 – 2020 BIOPROCESS ENGINEERING PROCESS DYNAMICS Prof. Dr.-Ing. Udo Reichl Prof. Dr.-Ing. Achim Kienle 66 Publications 2019 28 CSC 50 DRI 78 Publications 2020 COMPUTATIONAL METHODS IN SYSTEMS DATA-DRIVEN SYSTEM REDUCTION AND CONTROL THEORY AND IDENTIFICATION 89 Imprint Prof. Dr. Peter Benner Prof. Dr. Athanasios C. Antoulas 6 PREFACE The Dawning of a New Era g Introduction Did the beginning of 2020 mark the dawning of a new era - “before Covid” and “after Covid”? Indeed, many changes will endure, and the perception of the importance of the health system and the vulnerability of our society will also change. There will, of course, also be a lasting impact on our travel habits. A multitude of events have had to be canceled or postponed. Thanks to our experience with web-based events, the virtualization of workshops, symposia and even to an extent the larger conferences - of the DECHEMA as well as the MPI Magdeburg - went off without any appreciable problems. However, this required a great deal of effort and placed heavy demands on the flexibility of our employees and colleagues. How will the sharing of scientific knowledge look in future and what are the measures that we will need to develop to assist in this? Can we return to the conferences and conventions of the past, or will we find ourselves living in a virtual world in future? The latter sounds great if you already know one another and when the answers to the unresolved questions that are discussed do not cause too much controversy. Getting to know new people or building con- sensus, however, requires face-to-face interaction, an understanding of one’s counterpart, and not just as a face on a screen. The key topics for science, industry and society, however, remain unchanged. 2019 was the year of climate protection and the “Fridays for Future” movement. While the methods of ag- itation may change due to the Coronavirus, the central message remains, and I fully endorse it: we must combine our forces and develop technologies to become carbon neutral by 2050. For this reason, here at the MPI we can actually say that it is “business as usual”, when you consider the important contributions that have already been made on the subjects of energy and raw materials efficiency, the use of batteries and fuel cells, and energy system research. And even though, of course, there are many other important contributions that would also have been worth mentioning, it is entirely appropriate to highlight the fact that in the year of the Coronavirus the Bioprocess Engineering group at the MPI Magdeburg has focused its efforts on vaccine production processes. This work, in an area that has now been recognized as being of systemic importance, has been underway for many years. I think that it is greatly to be welcomed that since 2018 two of our young researchers have set out to establish their own company for the efficient continuous production of vaccines. I would like to wish them every success! And in what are at present somewhat difficult times, I am certain that the MPI will, in future, continue to make important contributions to research topics of truly vital relevance to our industrial society. Prof. Kurt Wagemann Executive Director, DECHEMA e.V. 8 INTRODUCTION I MILESTONES OF OUR MAX PLANCK INSTITUTE IN 2019 AND 2020 9 g Figure 1: Research Concept of our Institute g Figure 2: g Figure 3: g Figure 4: Prof. Dr.-Ing. Kai Sundmacher is the new spokesperson of the International Companions, friends and colleagues of Prof. Ernst Dieter Gilles Prof. Jennifer Wilcox, Professor at Pennsylvania University, Max Planck Research School Magdeburg. After six years, Prof. Dr.-Ing. met on the occasion of the Commemorative Colloquium in was awarded with the Max Planck Sabbatical Award. She Andreas Seidel-Morgenstern finished his term on August 30, 2019 with a honor of the scientific achievements of Prof. Dr.-Ing. h.c. mult. is shown here with Prof. Dr.-Ing. Kai Sundmacher during symbolic passing of the baton. Ernst Dieter Gilles on November 14, 2019, at our institute. her visit in Magdeburg in September 2019. The Max Planck Institute in Magdeburg – Our Mission and Recent Developments The global challenges associated with the ever-increasing New Research Groups chemical engineering processes and the automatic navigation for the development of a new class of therapeutic antibodies, gworld population, the depletion of natural resources and of inland water vessels to applications in systems biology and the spin-off project “ContiVir” (a two-year EXIST-Transfer of continuing climate change make the development of new and As of December 2020, the MPI consists of nine research biotechnology. His outstanding theoretical expertise, his ability Research project to advance gene therapy manufacturing, sustainable production technologies essential. This concerns, groups: four groups headed by MPI Directors (Professors to