Scientific Officer Chemistry Exam - 2015 (Final Answer Key) Chemistry Q.No: 1 The major detoxification reaction involved in Phase - I are all except. A Oxidation B Hydrolysis C Acetylation D Hydroxylation Q.No: 2 Which of the endogenous substance is detoxified through glucuronidation reaction ? A Aspirin B Methanol C Bilirubin D Phenyl Acetate Q.No: 3 Which of the following is not a conjugating agent in drug metabolisim? A Active acetate B Active sulfate C Active glucuronate D Active Bicarbonate Q.No: 4 Which of the following statements is not true about receptors ? A Most receptors are proteins situated in the cell membrane B Receptors contain a cleft- known as binding site C Receptors catalyze reactions on chemical messengers D Receptors bind to chemical messengers e.g. neurotransmitters etc Q.No: 5 The mechanism behind pesticide poisoning is A Irreversible binding with Acetyl choline esterase B Reversible binding with Acetyl choline esterase C Irreversible binding with nicotinic receptors D Reversible binding with nicotinic receptors Q.No: 6 Which one of the following have binding affinity but no intrinsic activity? A Agonist B Antagonist C Partial Agonist D Inverse Agonist Q.No: 7 Which of the following is not a requirement for a drug to act as an agonist ? A Functional group B Metabolic stability C Pharmacophore D Size Q.No: 8 Polycyclic aromatic hydrocarbons (PAH) in cigarette smoke may cause - A Inhibition of cytochrome P-450 and delayed metabolism B Inhibition of cytochrome P-450 and enhanced metabolism C Induction of cytochrome P-450 and delayed metabolism D Induction of cytochrome P-450 and enhanced metabolism Phase - I metabolic transformations introduce polar groups to the molecules and do not Q.No: 9 result in - A Decreased pharmacological activity B Increased pharmacological activity C Altered pharmacological activity D No effect on pharmacological activity Q.No: 10 The heterocycle Indole, undergoes - A Electrophilic substitution at 3 position B Electrophilic substitution at 2 position C Nucleophilic substitution at 3 position D Nucleophilic substitution at 2 position Q.No: 11 Suitable substrate for extrusion reactions. A Indole B Pyrazole C Quinoline D Imidazole Imidazole nucleus is found in - Q.No: 12 (i) Allantion (ii) Vit. B12 (iii) Pilocarpine (iv) Atropine A (i) and (ii) B (i) and (iv) C (ii) and (iii) D (i) and (iii) Quinolines on reaction with HNO3 and H2SO4 gives - Q.No: 13 A 5 and 8 nitroquinoline B 3 and 6 nitroquinoline C 2 and 4 nitroquinoline D 2, 4, 5 and 7 nitroquinoline Which of the following radiation from radio isotope cobalt-60 is used for sterilization of Q.No: 14 medical devices ? A Alpha B Gamma C X-Ray D Positron Q.No: 15 Radioactive half life of I131 and I125 respectively are- A 6 days and 40 days B 40 days and 6 days C 60 days and 8 days D 8 days and 60 days Q.No: 16 Which one of the following is a pure -emitter. A I131 B Fe59 C P32 D I125 Q.No: 17 Fe59 Radio isotope is produced by - A Neutron irradiation of Iron B particle irradiation of Iron C Electron bombardment of Iron D Positron irradiation of Iron Q.No: 18 To study the functioning of thyroid gland which radio-isotope is useful - A I131 B I125 C I121 D I120 Q.No: 19 To treat deeply seated tumors which radiation are useful. A B C D and both Q.No: 20 In radio active pharmaceuticals half life of a compound means- A The time taken for one half of the compounds to bind with serum albumin B The time taken for onset of its action C The time taken for the activity to decay to one half of its initial value D The time taken for its half metabolism in body Q.No: 21 Expectorant relives cough by - A By increasing the production of demulscent respiratory tract fluid B By acting as central cough suppressants C By removing the allergen in the respiratory tract D By acting as pharyngeal demulscent Q.No: 22 Which of the following agents have expectorant action - A Dextromethorphan B Diphenhydramine C Codeine D Ipecachanha Q.No: 23 Following are the excipients used in sterile products, which is odd one out- A Butylated hydroxy toluene B Tocopherols C Ascorbic acid D Ascorbic acid esters Q.No: 24 Which of the antioxidant is most suitable for mouthwash preparations - A Tocopheral B Ascorbyl palmitate C Cystein hydrochloride D Hydroquinone Q.No: 25 Polyethylene sorbitan monostearate has HLB value 9.6, results in - A Clear Solution B Translucent dispersion C Milky dispersion D Poor dispersion Q.No: 26 Agents used for seal coating of tablets- A Acacia solution B Sugarcane solution C Starch solution D Zein solution Q.No: 27 In methyl cellulose 100, 100 refers to - A Viscosity of 2% aqueous solution at 20oC B Viscosity of 1% aqueous solution at 20oC C Viscosity of 2% aqueous solution at 30oC D Viscosity of 1% aqueous solution at 30oC A retardant material that forms a hydrophilic matrix in the formulation of matrix tablet Q.No: 28 is - A CAP B HPMC C Polyethylene D Carnauba Wax Q.No: 29 Which of the following is used as pH dependent controlled release excipient- A Methyl Cellulose B Hydroxy propyl methyl cellulose phthalate C Carnuba Wax D Glyceryl monostearate Q.No: 30 The following is not true for local anaesthetic (LA)- The local anaesthetic is required in the unionized form for penetrating the A neuronal membrane The local anaesthetic approaches its receptor only from the intraneuronal face B of Na+ Channel The local anaesthetic binds to its receptor mainly when the Na+ channel is in C resting state D The local anaesthetic binds to its receptor in the ionized cationic form Q.No: 31 Which of the following is suitable for topical local anesthesia - A Procaine B Benzocaine C Halothane D Cyclopropane Q.No: 32 Injection of adrenaline along with a local anaesthetic results in - A Reduced dose of a local anaesthetic to produce nerve block B Prolonged the duration of local anaesthesia C Increased anaesthetised area D Reduced local toxicity of local anaesthesia Q.No: 33 The local anaesthetic with the longest duration of action is - A Procaine B Chloroprocaine C Lignocaine D Dibucaine Q.No: 34 Dissociative anaesthesia is produced by - A Ketamine B Fentanyl C Propofol D Both, Ketamine and Fentanyl Q.No: 35 Spinal anaesthesia is not suitable for- A Vaginal Delivery B Lower segment caesarian section C Prostatectomy D Mentally ill patients. General anesesthetics produce immobility in response to painful surgical stimuli by Q.No: 36 acting primarily at the - A Motor cortex B Basal ganglia C Spinal cord D Thalamus Q.No: 37 Which of the following is sign of deep anaesthesia? A Fall of Blood Pressure B Tears in eyes C Resistance to passive inflation of lungs D Patient makes swallowing movements Q.No: 38 The minimal alveolar concentration of an inhalational anaesthetic is a measure of its- A Therapeutic Index B Potency C Diffusibilty D Partition coefficient The following drug is used to reduce the frequency of angina pectoris as well as to Q.No: 39 terminate an acute attack. A Isosorbide dinitrate B Pentaerythritol trinitrate C Diltiazem D Amyl Nitrite Q.No: 40 Verapamil has drug intraction with digoxin- A It increase AUC for digoxin results in toxic dose B It decreases renal secretion of digoxin in urine C It is competitive substrate for renal P-gp D All of these Q.No: 41 Which adrenergic blocking agent primarily eliminated unchanged by renal excretion? A Propranolol B Metoprolol C Esmolol D Atenolol Q.No: 42 Which of the following is a diuretic antihypertensive? A Nifedipine B Hydrochlorothiazide C Atenolol D Methyldopa Q.No: 43 Amyl nitrite is a - A Antianginal drug B Anti arrythmic drug C Antihistaminic drug D Antihypertensive drug Q.No: 44 Atenolol is sometimes preferred to propranolol because - A It has both & adrenergic blockade B It has both vasodilatory and adrenergic blockade C It is a selective 1 antagonist D It is a 2 selective antagonist and has cardio-selective action Q.No: 45 Which of the cardiovascular drug may be used as inhalant? A Nitroglycerine B Digitoxin C Amyl Nitrite D Milrinone Q.No: 46 Indomethacin is a - A Salicylate B Fenamate C Arylpropionic acid D Indole Q.No: 47 Co-administration of NSAIDs with warfarin may often lead to - A Antagonistic interaction B Interaction due to competitive action C Electrolyte imbalance D Synergistic action Q.No: 48 In terms of hepatic damage, Ibuprofen is safer then Piroxicam as - A It has shorter half life than Piroxicam B It is not metabolized in liver C Its metabolites are highly water soluble D Its dose is less then Piroxicam In long term therapy of chronic inflammatory diseases, the most important limitation of Q.No: 49 aspirin is - A Electrolyte imbalance B Idiosyncratic reactions C Gastric mucosal damage D Salicylism Q.No: 50 True alkaloids are always presents in plants as - A Salts of inorganic acids B Salts of organic acids C Salts of meconic acids D Salts of benzoic acids Q.No: 51 Which of the following natural product do not have indole nucleus? A Reserpine B Vinblastine C Atropine D Ergotamine Q.No: 52 Reserpine on hydrolysis gives - A Reserpic acid + Methyl alcohol +Trimethoxy cinnamic acid B Reserpic acid + Acetic acid + Trimethoxy benzaldehyde C Reserpic acid + Methyl alcohol + Trimethoxy benzoic acid D Reserpic acid + Methyl alcohol + Trimethoxy benzaldehyde Q.No: 53 The opium alkaloids like morphine, codeine etc are presented in plant as salt of - A Benzoic acid B Meconic acid C Tartaric acid D Acetic acid Q.No: 54 Molecular formula for isoprene unit is - A C8H8 B C3H8 C C6H6 D C5H8 Q.No: 55 Camphor cannot be prepared from - A Volatile oils by complex formation with strong mineral acids.