Chicago | October 17-21 Tuesday Scienti ic Session Listings 452–638 Information at a Glance Important Phone Numbers Annual Meeting Headquarters Office Mercy Hospital Key to Poster Floor by Themes Logistics and Programming 2525 S Michigan Avenue The poster floor begins with Theme A and ends Logistics Chicago, IL 60616 with Theme H. Refer to the poster floor map at McCormick Place: Hall A, (312) 791‑6700 (312) 567‑2000 the end of this booklet. Programming Physicians Immediate Care Theme McCormick Place: Hall A, (312) 791‑6705 811 S. State Street A Development Chicago, IL 60605 B Neural Excitability, Synapses, and Glia: Volunteer Leadership Lounge (312) 566‑9510 Cellular Mechanisms McCormick Place: S505A, (312) 791‑6735 Walgreens Pharmacy C Disorders of the Nervous System General Information Booths (closest to McCormick Place) D Sensory and Motor Systems McCormick Place: 3405 S. Martin Luther King Drive E Integrative Systems: Neuroendocrinology, Gate 3 Lobby, (312) 791‑6724 Chicago, IL 60616 Neuroimmunology and Homeostatic Challenge Hall A (312) 791‑6725 (312) 326‑4064 F Cognition and Behavior Press Offices Venues G Novel Methods and Technology Development Press Room McCormick Place H History, Teaching, Public Awareness, and McCormick Place: Room S501ABC 2301 S. Martin Luther King Drive Societal Impacts in Neuroscience (312) 791‑6730 Chicago, IL 60616 Exhibit Management Fairmont Chicago, Millennium Park Hotel Note: Theme H Posters will be located in Hall A McCormick Place: Hall A, (312) 791‑6740 200 N. Columbus Drive beginning at 1 p.m. on Saturday, Oct. 17, and will Chicago, IL 60601 remain posted until 5 p.m., Sunday, Oct. 18. First Aid and Hospital Numbers (312) 565‑8000 First Aid Station McCormick Place: Level 2.5S, (312) 791‑6060 Hyatt Regency Chicago Downtown Hotel (not connected to McCormick Place) 151 E. Wacker Drive Chicago, IL 60601 (312) 565‑1234 Cover Image: Confocal image of a cholinergic single‑cell microculture. This neuron has been partially depleted of clathrin by RNAi. It is expressing GFP (pseudocolored orange‑yellow) and has been stained to show synapses (red) and clathrin (blue). Autaptic electrophysiological recordings in these cultures, together with electron microscopy, live cell imaging, or immunofluorescence, reveal that clathrin levels set limits for presynaptic plasticity. Francisco J. López‑Murcia, Stephen J. Royle, and Artur Llobet, 2014, The Journal of Neuroscience, 34(25): 8618‑8629. Complete Session Listing Tuesday AM SPECIAL LECTURE McCormick Place SYMPOSIUM McCormick Place 452. • Strange Synapses and Circuits of the Basal 454. All-Optical Interrogation of Neural Circuits — CME Ganglia — CME Tue. 8:30 AM - 11:00 AM — S100B Tue. 8:30 AM - 9:40 AM — Hall B1 Chair: M. HAUSSER Speaker: B. SABATINI, Harvard Med. Sch. Co-Chair: V. EMILIANI The basal ganglia are a phylogenetically old and This symposium will describe the nexus of dramatic evolutionarily conserved set of nuclei crucial for goal- recent developments in optogenetic probes, genetically oriented motor action. Nevertheless, many aspects of their encoded activity sensors, and novel microscopies, which circuitry, function, and regulation remain mysterious. Sabatini together allow the activity of neural circuits to be recorded will present recent work from his group revealing complex and manipulated using entirely light. Such an “all-optical” and unexpected interactions between nuclei of the basal approach promises to illuminate many fundamental ganglia. These include the surprisingly widespread use of challenges in neuroscience, including transforming our multiple fast acting neurotransmitters by neuromodulatory search for the neural code and the links between neural systems. The results will be discussed in terms of action circuit activity and behavior. initiation and reinforcement. 8:30 454.01 Introduction. 8:35 454.02 All-optical electrophysiology. A. COHEN. Harvard SYMPOSIUM McCormick Place Univ. 9:10 454.03 Spatially selective holographic photoactivation and 453. Synapse Formation and Neurodevelopmental functional fluorescence imaging in freely behaving mice. .V — CME Disorders EMILIANI. Univ. of Paris. Tue. 8:30 AM - 11:00 AM — S100A 9:45 454.04 All-optical neurophysiology in the awake mouse. K. AM Tues. Chair: L. MEI DEISSEROTH. Stanford Univ. Co-Chair: C. LEGAY 10:20 454.05 Targeting functional cortical ensembles using all- Neural transmission and plasticity are critical to how we optical interrogation during behaviour. M. HAUSSER. Univ. perceive, think, and react to the world. This relies on Col. London. synapses. Inappropriate formation of synapses has been implicated in neuropsychiatric disorders and loss of synaptic 10:55 454.06 Closing Remarks. connection may lead to neurodegenerative disorders. This symposium will provide insights into mechanisms that govern synapse formation and stability in various model MINISYMPOSIUM McCormick Place systems and shed light on pathophysiological mechanisms. 455. Modern Approaches Toward More Predictive Mouse 8:30 453.01 Introduction. Models of Neurodegenerative Diseases — CME 8:35 Molecular mechanisms controlling synapse 453.02 Tue. 8:30 AM - 11:00 AM — S406A formation and stability. J. PIELAGE. Friedrich Miescher Inst. for Biomed. Res. Chair: G. R. HOWELL Co-Chair: B. T. LAMB 9:10 453.03 MuSK and Wnts, their roles in synapse formation Animal models of neurodegenerative diseases have and maintenance. C. LEGAY. Paris Descartes Univ. provided important insights into the pathophysiology of 9:45 453.04 Genetic disorders of neuromuscular transmission. disease and suggested potential avenues for therapies. H. LOCHMÜLLER. Newcastle Univ. However, translation of these findings to the clinic has been limited. The latest advances in modeling different 10:20 453.05 Powering the brain: Glycolytic enzymes localize to neurodegenerative disease processes will be presented, as synapses under energy stress to support synaptic function. well as the cutting-edge technologies/methodologies that are D. A. COLÓN-RAMOS. Yale Univ. revolutionizing the field and should provide more predictive 10:55 453.06 Closing Remarks. models for neurodegenerative diseases. 8:30 455.01 Introduction. 8:35 455.02 • Modeling disease for therapy development in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 expansion. C. LAGIER-TOURENNE. UC San Diego. 8:55 455.03 Conditional and controllable models of Alzheimer’s disease for improved spatial and temporal control of transgene expression. J. JANKOWSKY. Baylor Col. of Med. 9:15 455.04 Novel animal models to study innate immunity and neurodegeneration. B. T. LAMB. Cleveland Clin. Fndtn. • Indicated a real or perceived conflict of interest, see page 160 for details. Neuroscience 2015 | Tuesday AM | 1 Indicates a high school or undergraduate student presenter. * Indicates abstract’s submitting author 9:35 455.05 Systems genetics of complex neurodegenerative MINISYMPOSIUM McCormick Place diseases. G. CARTER. The Jackson Lab. 457. Mood and Reward Networks in Chronic Pain 9:55 455.06 Applications of CRISPR-Cas9 for genome editing Conditions — CME in the mammalian brain. M. HEIDENREICH. Broad Inst. of MIT and Harvard. Tue. 8:30 AM - 11:00 AM — S103 10:15 455.07 Integrated mouse genetic and genomic approach Chair: V. ZACHARIOU to dissect Huntington’s disease pathogenesis. N. WANG. Co-Chair: I. YALCIN UCLA. This session presents new perspectives on mechanisms modulating sensory and affective components of chronic 10:35 455.08 Closing Remarks. pain. The panel will emphasize studies on networks involved in mood, reward, and motivation. Speakers will cover areas of investigation related to adaptations in cortical and striatal MINISYMPOSIUM McCormick Place networks under chronic pain conditions, the impact of pain in cortical plasticity and stress/anxiety disorders, the 456. Brainy and Handy: What Robotics and Prosthetics Can mechanisms by which the brain reward center modulates Learn from Touch Receptors in the Hand — CME motivation under chronic pain states, and the intracellular Tue. 8:30 AM - 11:00 AM — S105 targets of antidepressants in the brain reward center. Chair: E. P. GARDNER 8:30 457.01 Introduction. To honor Vernon Mountcastle, experts from somatosensory 8:35 457.02 The impact of pain on motivation. N. SCHWARTZ. neurophysiology, psychophysics, and bioengineering UCSF. will present studies of how the sense of touch might be translated for use in prosthetic or robotic hands. Speakers 8:55 457.03 How expectations, instructions, and beliefs shape will define the components of intelligent manipulative pain and aversive learning. L. ATLAS. NIH. sensors based on biological models in the hand. Touch 9:15 457.04 Presynaptic and postsynaptic mechanisms for receptors detect object shape, edges and texture, and chronic pain and anxiety. M. ZHUO. Univ. of Toronto. monitor grip force. Multisensor networks enhance touch information enabling translational application to adaptive 9:35 457.05 The anterior cingulate cortex as a substrate for mechanical hands. chronic pain-induced depression: Molecular, lesional and optogenetic evidences. I. YALCIN. UPR3212 CNRS. 8:30 456.01 Introduction. 9:55 457.06 Nucleus Accumbens subregions dissociate 8:35 456.02 Coding and use of tactile signals in object encoding of values for reward and pain. V. APKARIAN. manipulation tasks. R. S. JOHANSSON. Univ. Umea. Northwestern Univ. 8:55 456.03 Mechanisms of mechanosensory signaling in 10:15 457.07 Intracellular pathways in the Nucleus Accumbens discriminative touch receptors. E. A. LUMPKIN. Columbia