An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. E3m18Cyc: Arenibacter sp. E3M18 Cellular Overview Connections between pathways are omitted for legibility. a siderophore 1-(β-D Fe 3+ cefoperazone a siderophore a siderophore Fe 3+ Fe 3+ ribofuranosyl) glucosyl-oleandomycin N-acetyl-α-D- 3+ 3+ N-acetyl-α-D- N-acetyl-α-D- Fe Fe nicotinamide glucosamine glucosamine glucosamine Ferric Ferric Ferric siderophore ABC- iron(III) ABC Ribosyl Multidrug N-acetylglucosamine N-acetylglucosamine N-acetylglucosamine siderophore siderophore transport type Fe3+ transporter, nicotinamide resistance related transporter, related related transporter, transport transport system, transport ATP-binding transporter, protein transporter, NagX system, system, periplasmic system protein, binding protein; putative protein TonB cefoperazone N-acetyl-α-D- N-acetyl-α-D- β N-acetyl-α-D- 1-( -D glucosyl-oleandomycin glucosamine glucosamine ribofuranosyl) glucosamine a siderophore a siderophore Fe 3+ Fe 3+ Fe 3+ Fe 3+ nicotinamide a siderophore Fe 3+ tolB protein Amino Acid Degradation Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Aromatic Compound Biosynthesis C1 Compound Utilization and Assimilation precursor, Fatty Acid and Lipid Biosynthesis periplasmic an oxidized 3-benzyl-3,6-dihydroxy-6- a peptidoglycan ditrans,octacis- 2-bromo-3-(4- 1-stearoyl- 1-myristoyl- 1-palmitoyl- (R)-N-formyl-β- a 2-acetyl-1-alkyl- an N-terminal- 3-oxo-2-(cis-2'-pentenyl) (S)-3- D-sedoheptulose 1-cis-vaccenoyl- 2,6-dioxo-6- a [lysine- 3S-(4- 1-myristoyl- a 1-acyl-sn a uridine 32 1-pyrroline- L-methionyl-L- a protein-L- L-isoleucine degradation I N 5 -methyltetrahydromethanopterin glutathione 2,3,5,6-tetrachlorohydroquinone glutathione indolylmethylisothiocyanate glutathione glutathione a 2,3,4-saturated a 2,3,4-saturated 2- an acyl-[acyl- O-succinyl-L- 2-oxoglutarate O-phospho- a ribonucleoside a 1,4-α-D-glucan isoquinoline a dipeptide superpathway of superpathway of tetrahydrofolate biosynthesis biotin biosynthesis from folate polyglutamylation 2,3-dihydroxybenzoate Fermentation mixed acid fermentation L-leucine degradation I L-threonine degradation I L-histidine degradation I L-tryptophan degradation L-asparagine L-citrulline degradation L-serine degradation L-methionine L-alanine degradation IV formaldehyde oxidation coenzyme F (hydroxymethyl)-diketopiperazine with (L-alanyl- undecaprenyldiphospho- O-succinyl-L-homoserine nitrophenyl)propanoate sn-glycerol a myristoyl-[acp] sn-glycerol a palmitoleoyl-[acp] sn-glycerol methanethiol a butanoyl-[acp] cys hydroxy-L-kynurenine an arachidoyl-[acp] sn-glycero-3- L-methionyl-L- pimeloyl-CoA ala -cyclopentane-1-(3R- hydroxyhexadecanoyl- 1-phosphate sn-glycerol- phenylhexa- biosynthesis- hydroxyphenyl) sn-glycerol -glycerol 3- in tRNA 4-hydroxy-2- alanine dipeptide methionine- Methionine superpathway of menaquinol-8 biosynthesis I NAD de novo biosynthesis pyridoxal 5'-phosphate biosynthesis I siroheme biosynthesis NAD palmitate biosynthesis II (bacteria and plants) 4-hydroxyphenylpyruvate 420 H O ATP fatty acyl-[acp] lysophosphatidate carrier protein] homoserine L-homoserine diphosphate ITP geranylgeranyldiphosphate [2Fe-2S] iron-sulfur cluster biosynthesis demethylmenaquinol- NAD de novo biosynthesis NAD salvage palmitoleate biosynthesis degradation II VII (THF pathway) formate γ β 2 3-phosphate 3-phosphate 3-phosphate phosphocholine seryl-[protein] hydroxyhexanoyl)-CoA CoA Fructose- 3-phosphate 3-enoate 3-phosphate phosphate carboxylate (R)-S-oxide ABC tolB protein phosphorylation and 8-amino-7-oxononanoate I phosphatidylglycerol gondoate biosynthesis (anaerobic) I (via anthranilate) degradation I Coenzyme F420-dependent Probable glutathione Probable glutathione -D-glutamyl-L- N-acetyl-(N-acetyl- -D- Probable glutathione O-acetylhomoserine Probable 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- O-acetylhomoserine 2-oxoglutarate 3-oxoacyl-[acyl-carrier- O-acetylhomoserine Kynurenine Enoyl-[acyl-carrier- Platelet- Methionine Ribonucleotide 1-acyl-sn-glycerol- protein LysW]- -3-hydroxy- 1-acyl-sn-glycerol- 1-acyl-sn-glycerol- 1,4-alpha- Ribosomal Isoquinoline 1- Aminoacyl- Aminoacyl- biosynthesis I (via mevalonate) 6 biosynthesis I II (from tryptophan) I (from aspartate) pathway IV (from biosynthesis I (from biosynthesis oxidation to CO Alkaline 8-amino-7- Enoyl-CoA Enoyl-CoA Alkaline bisphosphate 2-hydroxy- 1-pyrroline- Peptide met transporter met precursor, D-erythrose transhydrogenation biosynthesis II ile 2 N5,N10-methylene S-transferase-related S-transferase-related lysyl-D-alanyl- glucosaminyl)muramoyl- S-transferase-related sulfhydrylase (EC 2.5.1.49) glutathione S- 3-phosphate 3-phosphate 3-phosphate 3-phosphate sulfhydrylase dehydrogenase protein] synthase, sulfhydrylase formamidase, protein] reductase aminopeptidase reductase C-terminal-γ- propanoyl-CoA glucan large subunit oxidoreductase: histidine histidine chorismate uroporphyrinogen-III nicotinamide riboside) a tetrahydrofolate chorismate phosphoenolpyruvate thr his ala phosphodiesterase I activating factor oxononanoate hydratase hydratase phosphodiesterase I 3-phosphate 6-oxo-6- Enoyl-CoA 3-phosphate 3-phosphate 4-hydroxy-2- methionine periplasmic all-trans- 4-phosphate 8-amino-7-oxononanoate an acetoacetyl-[acp] (5Z)-dodec-5-enoate) (non-plastidic) leu L-citrulline ser met formaldehyde tetrahydromethanopterin transmembrane transmembrane D-alanine) L-alanyl-Cell γdivision-D-glutamyl-L- transmembrane transferase-related E1 component KASI (EC 2.3.1.41): 3- bacterial [FMN] (EC 1.3.1.9): aldolase class (L-ornithyl)Acetylornithine (glycogen) pseudouridine Isoquinoline 1- dipeptidase dipeptidase ATP-binding acetyl-CoA L-cysteine desulfurase 1,4-dihydroxy- GTP 1-(β-D + Branched-chain trp asn / O-succinylhomoserine acyltransferase acyltransferase acyltransferase acyltransferase (EC 2.5.1.49) / O- (EC 2.5.1.49) / O- acetylhydrolase (EC 3.4.11.18) synthase [isoleucine of class II acyltransferase phenylhexa- hydratase acyltransferase acyltransferase hexaprenyl trp asp Siroheme synthase / NAD a malonyl-[acp] an oleoyl-[acp] Isochorismate tyr Branched-chain amino L-serine dehydratase Histidine ammonia- Ornithine Alanine dehydrogenase formate protein (EC 2.5.1.18): protein (EC 2.5.1.18): protein FtsI protein (EC 2.5.1.18): (EC 3.1.4.1) / Nucleotide (EC 1.2.4.2): 2- [isoleucine (EC 3.1.4.1) / Nucleotide II (EC 4.1.2.13) aminotransferase branching carboxylate sulfoxide Acetyl-CoA 2-naphthoate ribofuranosyl) Adenosylmethionine-8- a (5Z)-dodec- amino acid Tryptophan 2,3- L-asparaginase L-serine Methionine reductase and related pentapeptide lysyl-D-alanyl-D-alanine sulfhydrylase (EC 2.5.1.48) transmembrane (EC 2.3.1.51): 1- (EC 2.3.1.51): 1- (EC 2.3.1.51): 1- (EC 2.3.1.51): 1- succinylhomoserine oxoacyl-[acyl-carrier- succinylhomoserine (EC 3.5.1.9): Enoyl-[acyl-carrier- IB gamma : Methionine (EC 2.3.1.47) degradation] (coenzyme B12- (EC 2.3.1.51): 1- 2,4-dienoate -L-glutamate [isoleucine (EC 2.3.1.51): 1- (EC 2.3.1.51): 1- synthase F oxidoreductase (Peptidase (Peptidase Isochorismate diphosphate Precorrin-2 oxidase NAD kinase DHAP 3-oxoacyl-[acyl- synthase (EC Biosynthetic acid aminotransferase (EC 4.3.1.17) lyase (EC 4.3.1.3): carbamoyltransferase (EC 1.4.1.1): Alanine Formate Probable glutathione Probable glutathione [Peptidoglycan Probable glutathione pyrophosphatase oxoglutarate degradation] pyrophosphatase : Fructose- (EC 2.6.1.11): enzyme, GH- deaminase reductase acetyltransferase Cysteine 1,4-dihydroxy- Tryptophan 2,3- nicotinamide amino-7-oxononanoate Dihydrofolate synthase L-allo-threonine 3-oxoacyl-[acyl-carrier 5-enoyl-[acp] Phosphoenolpyruvate Pyruvate kinase (EC aminotransferase dioxygenase (EC (EC 3.5.1.1): L- dehydratase gamma- flavin-dependent : O-acetylhomoserine protein (EC acyl-sn-glycerol- acyl-sn-glycerol- acyl-sn-glycerol- acyl-sn-glycerol- sulfhydrylase protein] synthase, sulfhydrylase Kynurenine protein] reductase subunit (EC aminopeptidase : 8-amino-7- (EC 4.2.1.17) / 3- dependent) acyl-sn-glycerol- hydrolase degradation] acyl-sn-glycerol- acyl-sn-glycerol- (EC 4.2.1.70) beta subunit D) (EC D) (EC Methionine synthase (EC GTP (EC 1.3.1.76) / Ribosylnicotinamide (EC 2.7.1.23): 3-oxoacyl- Glycerol-3- carrier-protein] 5.4.4.2) @ Aromatic (EC 2.6.1.42): : G1RF7-4550 Histidine ammonia- (EC 2.1.3.3): Ornithine dehydrogenase a 5,10- dehydrogenase S-transferase-related S-transferase-related synthetase] S-transferase-related (EC 3.6.1.9): Alkaline dehydrogenase (EC 4.2.1.17) / 3- (EC 3.6.1.9): Alkaline bisphosphate Acetylornithine 13-type (EC (EC 3.5.4.22) MsrB (EC (EC 2.3.1.9) desulfurase 2-naphthoate dioxygenase (EC aminotransferase (EC 6.3.2.12) @ aldolase (EC 2.1.2.1) protein] reductase (EC carboxylase (EC 4.1.1.31) 2.7.1.40): Pyruvate (EC 2.6.1.42): 1.13.11.11): Tryptophan asparaginase (EC 4.3.1.17) lyase (EC oxidoreductases: sulfhydrylase (EC 2.5.1.18): Probable 3-phosphate 3-phosphate 3-phosphate 3-phosphate (EC 2.5.1.48): O- 3-oxoacyl-[acyl-carrier- (EC 2.5.1.48): O- formamidase, Enoyl-[acyl-carrier- 3.1.1.47): Platelet- (EC 3.4.11.18) oxononanoate hydroxyacyl-CoA (EC 1.17.4.1): 3-phosphate (EC 3.7.1.-)