Proteins, Peptides and Enzymes 2010 www.abcam.com Contents Welcome to Abcam About Abcam . .1 Proteins and peptides at Abcam . .2 The Proteins resource page . .2 The Proteins team . .2 Benefits of an Abcam account . .3 AbreviewsSM and AbpointsSM . .3 Catalogue contents Abbreviations Species key . .4 Applications key . .4 Product list Protein > Full length . .5 Protein > Protein fragment . .40 Enzyme > Peptide . .53 Enzyme > Full length . .57 Enzyme > Protein fragment . .68 Peptide . .72 Technical help Protein resources at Abcam . .144 Product datasheet guide . .145 Protocols, tips and poster library . .146 Ordering and contact details Contact details . .147 Local offices and distributors . .148 Required information for ordering . .149 Abcam’s terms and conditions . .150 Product index Product index . .151 View complete catalog and ordering information: www.abcam.com Technical support: www.abcam.com/technical | Protein resources: www.abcam.com/proteins Welcome to Abcam About Abcam Abcam, with offices in Cambridge, U.K., Cambridge, MA, U.S.A., Tokyo, Japan and Hong Kong was founded in 1998 by Dr. Jonathan Milner, then a researcher at Cambridge University, U.K. “Like many life science researchers, I was frustrated by the time it took to locate and select antibodies essential for my research. This was largely due to poor information and out-of-date catalogs from the vast range of suppliers who were spread across many countries. In some cases, I also experienced difficulties with companies whose products were unreliable and whose customer service was slow and to Welcome Abcam unhelpful. My vision was to build a company that offered reliable cutting-edge products and great customer service.” It was a tough vision - Abcam was created to sell the best antibodies in the world with the most comprehensive, honest and up- to-date datasheets, fast delivery, helpful customer service and comprehensive technical support. Today, Abcam has extended its catalog with thousands of proteins, enzymes and peptides. Several years on and with thousands of products across our range, Abcam ships to scientists in over 70 countries around the world. Abcam is committed to the following fundamental principles that have seen us become the first choice for thousands of life-scientists throughout industry and academia: • Quality of products and datasheets • Helpful technical support and online technical resources • Friendly customer service • Fast delivery Comprehensive We have a policy of honesty - our customers know everything that we know about our products, as soon as we know it. Everything we know about each product is posted on the datasheet. To achieve exceptional levels of quality for our customers we provide: • Comprehensive datasheets • Customers’ AbreviewsSM of our products • Product-specific protocols used by our customers • Customers’ technical questions and our answers for each product • Product information and new products updated daily Helpful Our Scientific Support and Customer Service departments are full of scientists that have many years of experience working with the types of products that we supply to our customers. We provide continuous order progress updates, so that you always know what is happening with your order and when you should expect to receive it. Over 8000 proteins and peptides available Customer Service Tel: Europe +44-(0)1223-696000 | Hong Kong (852)-3793-3454 Japan +81-(0)-3-6805-8450 | U.S.A. 1-617-225-2272 (Toll free: 1-888-77-ABCAM) 1 Worldwide reach, next day delivery We currently ship to 70 countries worldwide. To get our products to you as quickly as possible we have extended our cut off times for same day dispatch of in-stock orders. Customers in North America can now place orders up to 8:00pm EST, and in mainland Europe up to 4:00pm GMT, for next day delivery in most countries. Proteins and peptides at Abcam Abcam’s range of over 8,000 proteins and peptides has a breadth and depth that is hard to beat. Every month, over 150 new products are added to the catalog. The Proteins Resource page Our Proteins Resource page enables browsing of the different categories of protein products including enzymes, Fc chimeric Welcome to Welcome Abcam proteins, blocking peptides and recombinant proteins. www.abcam.com/proteins The Proteins Team Abcam has a specialized team working on sourcing and testing the best proteins available. James R. Streggles PhD OEM James works to increase the range of products available on Abcam’s catalog, with a particular interest in developing Abcam’s range of recombinant and native proteins. He has been with Abcam since 2004. Catherine Tarrade Marketing Catherine promotes Abcam’s range of proteins and peptides by developing the online and paper resources available to our customers. Over 8000 proteins and peptides available View complete catalog and ordering information: www.abcam.com 2 Technical support: www.abcam.com/technical | Protein resources: www.abcam.com/proteins Benefits of an Abcam Account Take full advantage of all our online resources by opening an account. • Earn AbpointsSM • Buy quickly and efficiently online • Customize your proteins updates. We can notify you by email of new and updated proteins and peptides related directly to the target families which interest you Welcome to Welcome Abcam AbreviewsSM AbreviewsSM are our unique system for enabling customers to feedback to you and us about the performance of our proteins and peptides. It is important to know how our products perform under different conditions and that they are working as expected. We encourage this feedback (positive and negative) by awarding AbpointsSM for each AbreviewSM: AbreviewSM Action Abpoints Description Fast Track 950 Be the 1st researcher to submit conclusive positive or negative data via an AbreviewSM bonus Abreview about one of our Fast Track antibodies and earn this bonus (in addition to the AbpointsSM that you will earn for submitting your Abreview). Promotion variable The number of AbpointsSM depends on the terms of the promotion Submit an AbreviewSM up to 120 Each unique combination of protein, application and sample species that you review, earns you AbpointsSM. Submit an image with your 100 When you submit an image to accompany your AbreviewSM and it is published, AbreviewSM you will receive 100 extra AbpointsSM. For AbreviewSM and image publication criteria, please see the AbreviewsSM section of the website. Customer AbreviewsSM are posted on the product datasheets for others to browse. You can contact the reviewer to ask further questions too! AbpointsSM In addition to AbreviewsSM, you can also earn AbpointsSM by buying your proteins and peptides online at www.abcam.com or by registering your interests there. To accumulate AbpointsSM, you will need to claim them directly to www.abcam.com/abpoints/claim. If the claim code is valid, the AbpointsSM will be added to your account and will be instantly available to spend and you can get a reward. Customer Service Tel: Europe +44-(0)1223-696000 | Hong Kong (852)-3793-3454 Japan +81-(0)-3-6805-8450 | U.S.A. 1-617-225-2272 (Toll free: 1-888-77-ABCAM) 3 Abbreviations Species key Key Species Key Species Key Species Many wide range of species H Horse T Tetrahymena species Hu Human X Xenopus laevis A Algae In Insect Y all Yeast At Arabidopsis thaliana K Kangaroo Am Amphibian Li Lizard A salmonicida Aeromonas salmonicida Av Avian Mm Mouse A. terreus Aspergillus terreus Ba Baboon Ma Mammals B burgdorferi Borrelia burgdorferi Bu Burkholderia spp. Mi Mink HAV Hepatitis A Virus Ca Cat Mk Monkey HEV Hepatitis E Virus Ce Caenorhabditis elegans Op Opossum L monocytogenes Listeria monocytogenes Ch Chicken Pi Pig M eupeus Mesobuthus eupeus Abbreviations C Cow P Plants M tamulus Mesobuthus tamulus De Deer Q Quail P furiosus Pyrococcus furiosus D Dog Rb Rabbit P furiosus Pyrococcus furiosus Dm Drosophila melanogaster Rt Rat P magnus Peptostreptococcus magnus El Elk Re Reptiles P sp Pseudomonas sp Ec Escherichia coli Ro Rodents S japonicum Schistosoma japonicum Fe Ferret Sp Schizosaccharomyces pombe S simulans Staphylococcus simulans Fi Fish Sc Sacchromyces cerevisiae S sp Streptococcus sp Gt Goat S Salamander S typhimurium Salmonella typhimurium G Goose Sha Shark T acidophilum Thermoplasma acidophilum Gp Guinea pig Sh Sheep T pallidum Treponema pallidum Ha Hamster Sn Snake U urealyticum Ureaplasma urealyticum Applications key Key Applications Key Applications AF Acetone fixed IHC-F Immunohistochemistry (Formalin fixed sections) Agg Agglutination IHC-Fr Immunohistochemistry (Frozen sections) AI Adhesion inhibition IHC-P Immunohistochemistry (Formalin-fixed AP Affinity purification paraffin-embedded sections) BL Blocking IM Immunomicroscopy CCIe Counter current Inhib Inhibition assay immunoelectrophoresis IP Immunoprecipitation ChIP Chromatin immunoprecipitation IRMA Immunoradiometric assay Conjugation Conjugation ISH In situ hybridization DID Double immunodiffusion Mct Microcytotoxicity testing Dot Dot blot Neut Neutralizing EC Experimental control P Purification EIA Enzyme immunoassay PA Prothrombin assay ELISA ELISA PCC Primary cell culture EM Electron microscopy PCR Polymerase chain reaction EMSA Electrophoretic mobility shift assay RIA Radioimmunoassay FACS Fluorescence activated cell sorting RID Radial immunodiffusion FC Flow cytometry RIe Rocket immunoelectrophoresis FuncS Functional studies RImm Radial immunodiffusion GSA Gel supershift assays RipA Radioimmunoprecipitation assay H Histology SB Southern blot I-ELISA Indirect ELISA TCC Transfected cell culture IA