Stichodactyla toxin ShK - #08SHK001 - CAS : 165168-50-3 Product information Animal toxins for life-sciences Selective blocker of Kv1.3 www.smartox-biotech.com ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Phone : +33(0) 456 520 869 Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium Fax : +33(0) 456 520 868 channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and [email protected] Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, Smartox Biotechnology it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM. 570 rue de la chimie 38400 Saint Martin d’Hères France Fluorescent ShK also available: TMR-ShK - #SAT001 Prices 5x10 µg – 100 € 100 µg – 120 € 500 µg – 375 € Technical information AA sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17- 28 32 35 Related products Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys -Arg-Lys-Thr-Cys -Gly-Thr-Cys -OH 3 35 12 28 17 32 Disulfide bridges: Cys -Cys , Cys -Cys and Cys -Cys TMR-ShK - # SAT001 Length (aa): 35 Solubility: water and saline buffer Margatoxin - #08MAG001 Formula: C169H274N54O48S7 CAS number: 165168-50-3 HsTx1 - # 08NEU001 Molecular Weight: 4054.85 Da Source: Synthetic (Dap22)-ShK - # 13SHD001 Appearance: White lyophilized solid Purity rate: > 97 % ADWX-1 - # 13ADW001 Agitoxin-2 - # 13AGI002 References Tarcha EJ., et al.. - J Pharmacol Exp Ther. Gilhar A., et al.- J Invest Toxin of the month – free sample program Dermatol. Chen R., et al.- Biophys J. Each month, Smartox Biotechnology offers a sample of a selected toxin for absolutely free. To be informed, visit our website each month, subscribe our newsletter or follow us on social networks. Clic HERE Ordering information Smartox products are available worldwide. To place an order, please contact us by phone or email or find out your local distributor on our website. We Range of blockers accept credit card payment. Voltage-gated sodium channels Acid-sensing ion channels Voltage-gated calcium channels Chloride channels Potassium channels Nicotinic acetylcholine receptors Voltage-gated potassium channels Purinergic receptors Calcium activated potassium channels TRP channels hERG channel Mechanosensitive ion channels Inward rectifying potassium channels NMDA receptors Follow us on All products are intended for research use only and are not intended for diagnostic or therapeutic use, not for use in humans www.smartox - biotech.com About Smartox .