Anti-FATE1 monoclonal antibody, clone 8C6 (DCABH-3733) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to FATE1 Antigen Description The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. Immunogen Recombinant full length protein, corresponding to amino acids 1-183 of Human FATE1 produced in HEK293T cells. Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone 8C6 Purity Protein G purified Purification This antibody is purified from Mouse ascites fluid by affinity chromatography. Conjugate Unconjugated Applications WB, IHC-P, ICC/IF Positive Control HEK293T cells transfected with pCMV6-ENTRY FATE1 cDNA; Human ovary adenocarcinoma tissue; COS7 cells transiently transfected by pCMV6-ENTRY FATE1. Format Liquid Size 100 μl Buffer pH: 7.30; Preservative: 0.02% Sodium azide; Constituents: 48% PBS, 50% Glycerol, 1% BSA Preservative 0.02% Sodium Azide 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Storage store at -20°C. Avoid repeated freeze / thaw cycles. Ship Shipped at 4°C. GENE INFORMATION Gene Name FATE1 fetal and adult testis expressed 1 [ Homo sapiens ] Official Symbol FATE1 Synonyms FATE1; fetal and adult testis expressed 1; fetal and adult testis-expressed transcript protein; cancer/testis antigen 43; CT43; FATE; BJ-HCC-2 antigen; tumor antigen BJ-HCC-2; fetal and adult testis expressed transcript protein; Entrez Gene ID 89885 Protein Refseq NP_149076 UniProt ID Q969F0 Chromosome Location Xq28 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.