Plasmodium falciparum malaria in the Greater Mekong Sub-region: Elucidating parasite migration and genomic signatures of selection Item Type dissertation Authors Jacob, Christopher George Publication Date 2015 Abstract Current estimates place over one third of the world's population at risk of contracting malaria, with approximately 300-500 million cases of clinical illness each year. Among these cases it is estimated more than 600k end in death, mostly among child... Keywords migration; selection; Asia, Southeastern; Genetics; Malaria; Plasmodium falciparum Download date 24/09/2021 15:23:13 Link to Item http://hdl.handle.net/10713/4589 Curriculum Vitae Christopher George Jacob Graduate Program in Life Sciences University of Maryland Baltimore Contact Information Center for Vaccine Development University of Maryland School of Medicine 685 W. Baltimore St. Suite 480 Baltimore, MD 21201 E-mail: [email protected] Education 2008 B.S. College of Mount Saint Joseph, Cincinnati, OH Biology, Chemistry minor (Summa Cum Laude) 2015 (expected) Ph.D. University of Maryland Baltimore, Baltimore, MD Molecular Medicine (Advisor: Christopher Plowe) Post Graduate Education and Training 2011 Workshop on Molecular Evolution Fort Collins, Colorado, U.S.A. Director: Michael Cummings Employment History Other Employment 2008-2009 Cytogenetic laboratory assistant Division of Human Genetics, Cincinnati Children’s Hospital, Cincinnati, OH 2009-present Graduate Research Assistant Center of Vaccine Development, Department of Medicine University of Maryland School of Medicine, Baltimore, MD Thesis Advisor: Christopher Plowe Institute for Genome Sciences University of Maryland School of Medicine, Baltimore, MD Advisor: Joana Carneiro Da Silva Department of Microbiology and Immunology University of Maryland Baltimore, Baltimore, MD Advisor: Shiladitya DasSarma Honors and Awards 2004-2008 Presidential Scholarship, College of Mount Saint Joseph 2004-2008 Art and Science Award, College of Mount Saint Joseph 2008 Biology Department Award, College of Mount Saint Joseph Professional Society Memberships 2011-present American Society of Tropical Medicine and Hygiene Teaching Service Graduate Courses 2010-2011 Teaching Assistant, Mechanisms in Biomedical Sciences (Bioinformatics Module) (GPLS 601) Graduate Program in Life Sciences, University of Maryland Baltimore, 50 Graduate Students 2011 Teaching Assistant, Beginning PERL for Bioinformatics (GPLS 618) Graduate Program in Life Sciences, University of Maryland Baltimore, 10 Graduate Students 2012 Teaching Assistant, Genomics and Bioinformatics (GPLS 716) Graduate Program in Life Sciences, University of Maryland Baltimore, 15 Graduate Students Publications Peer-Reviewed Journal Articles (*equal authorship) 1. Capes MD, Coker JA, Gessler R, Grinblat-Huse V, Dassarma SL, Jacob CG , Kim JM, Dassarma P, Dassarma S. The information transfer system of halophilic archaea. Plasmid 2011 Mar; 65(2):77-101 2. Shaukat AM, Gilliams EA, Kenefic LJ, Laurens MB, Dzinjalamala FK, Nyirenda OM, Thesing PC, Jacob CG , Molyneux ME, Taylor TE, Plowe CV, Laufer MK. Clinical manifestations of new versus recrudescent malaria infections following anti-malarial drug treatment. Malaria Journal 2012 Jun; 11(1):207 3. Takala-Harrison S, Jacob CG* , Clark TG*, Cummings MP, Miotto O, Dondorp AM, Fukuda MM, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders D, Socheat D, Ariey F, Pyae Phyo A, Starzengruber P, Fuehrer HP, Swoboda P, Stepniewska K, Flegg J, Arze C, Cerqueira GC,. Silva JC, Ricklefs S, Porcella SF, Stephens RM, Adams M, Kenefic L, Campino S, Auburn S, MacInnis B, Kwiatkowski DP, Su X,. White NJ, Ringwald P, and Plowe CV. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. PNAS 2013 Jan 2;110(1):240- 5 4. Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Lindegardh N, Tarning J, Imwong M, Jacob CG , Rasmussen C, Perin J, Ringwald, P, Nyunt MM. Reduced Susceptibility of Plasmodium falciparum to Artesunate in Southern Myanmar. PLOS One 2013 Mar 8:8(3) 5. Laurens MB, Billingsley P, Richman A, Eappen AG, Adams M, Li T, Chakravarty S, Gunasekera A, Jacob CG , Sim BKL, Edelman R, Plowe CV, Hoffman SL, Lyke KE. Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection. PLOS One 2013 July 16:8(7) 6. Khattak AA, Venkatesan M, Jacob CG , Artimovich EM, Nadeem MF, Nighat F, Hombhanje F, Mita T, Malik SA, Plowe CV. A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan. Malaria Journal 2013 Sept; 12:300 7. Munro, JB, Jacob CG, Silva JC. A novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasites. Journal of Molecular Evolution 2013 Sept; 77(3) 92-106 8. Jacob CG , Tan JC, Miller BA, Tan A, Takala-Harrison S, Ferdig MT, Plowe CV. A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity. BMC Genomics 2014 Aug 26;15(1):719 9. Jacob CG*, Takala-Harrison S*, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NTT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Socheat D, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto OM, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV. Independent emergence of Plasmodium falciparum artemisinin resistant mutations in Southeast Asia. Journal of Infectious Diseases, Epub 2014 Sep. 1 10. Brown, T, Jacob CG , Silva JC, Takala-Harrison S, Djimde A, Dondorp A, Fukuda M, Noedl H, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistance show no evidence of hypermutator phenotype. Infection, Genetics, and Evolution, Epub 2014 Dec. 13 11. Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, Lim P, Mead D, Oyola S, Dhorda M, Imwong M, Woodrow C, Manske M, Stalker J, Drury E, Campino S, Amenga-Etego L, Thanh TNN, Tran HT, Ringwald P, Bethell D, Nosten F, Phyo AP, Pukrittayakamee S, Chotivanich K, Chuor CM, Nguon C, Suon S, Sreng S, Newton PN, Mayxay M, Khanthavong M, Hongvanthong B, Htut Y, Han KT, Kway MP, Faiz MA, Fanello CI, Mokuolu OA, Jacob CG , Takala-Harrison S, Plowe CV, Day NP, Dondorp AM, Spencer CAC, McVean G, Fairhurst RM, White NJ, Kwiatkowski DP. Genetic architecture of artemisinin-resistant Plasmodium falciparum . Nature Genetics, Epub 2015 Jan. 19 12. Travassos MA, Coulibaly D, Laurens MB, Dembele A, Tolo Y, Kone AK, Traore K, Niangaly A, Guindo A, Wu Y, Berry AA, Jacob CG, Takala-Harrison S, Kouriba B, Lyke KE, Diallo DA, Doumbo OK, Plowe CV, Thera MA. Hemoglobin C trait provides protection from clinical falciparum malaria comparable to that of Hemoglobin S trait in Malian children. Journal of Infectious Diseases (under review) 13. Huang F, Takala-Harrison S, Jacob CG , Liu H, Sun X, Yang H, Nyunt MM, Adams M, Zhou S, Xia Z, Ringwald P, Bustos, MD, Tang L, Plowe CV. A single mutation in K13 predominates in Souther China and is associated with delayed clearance of Plasmodium falciparum following artemisinin treatment. Journal of Infectious Diseases (under review) 14. Chaorattanakawee S, Saunders DL, Sea D, Chanarat N, Yingyuen K, Sundrakes S, Saingam P, Buathong N, Sriwichai S, Chann S, Se Y, Yom Y, Heng TK, Kong N, Kuntawunginn W, Tanghongchaiwiriya K, Jacob CG , Takala-Harrison S, Plowe CV, Lin JT, Chuor CM, Satharath P, Tyner SD, Gosi P, Teja-isavadharm P, Lon C, Lanteri CA. Ex vivo drug susceptibility and Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) profiling of clinical isolates from Cambodia in 2008-2013 suggest emerging piperaquine resistance. (in preparation) Book Chapters 1. Jacob CG , Plowe CV. Malaria Genomics and the Developing World. Genomics Applications for the Developing World, Advances in Microbial Ecology, Nelson KE, Jones-Nelson B (eds.), Springer Science Business Media, New York, 2012, 117-130 Abstracts (*Presented) 1. Munro JB, Jacob CG , Silva JC. A novel clade of eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasites. American Society of Tropical Medicine and Hygiene Annual Meeting, December 2011, Philadelphia, PA. 2. Takala-Harrison S, Imwong M, Jacob CG , Arze C, Dondorp A, Fukuda M, Nosten F, Noedl H, Bethell D, Se Y, Lon C, Tyner S, Saunders D, Socheat D, Pyae Phyo A, Starzengruber P, Swoboda P, Stepniewska K, Flegg J, Cerqueira G, Silva JC, Adams M, Kenefic L, Bailey J, Niangaly A, White N, Ringwald P, Plowe CV. ARC3: Associations between candidate gene polymorphisms and parasite clearance rate following treatment with artemisinins. American Society of Tropical Medicine and Hygiene Annual Meeting, December 2011, Philadelphia, PA. 3. Takala Harrison S, Clark T, Cummings M, Jacob CG , Miotto O, Dondorp A, Fukuda M, Nosten F, Noedl H, Imwong M, Bethell D, Se D, Lon C, Tyner S, Saunders D, Socheat D, Pyae Phyo A, Starzengruber P, Swoboda P, Stepniewska K, Flegg J, Cerqueira G, Silva JC, Arze C, Ricklefs S, Porcella S, Adams M, Kenefic L, Campino S, Auburn S, Manske M, MacInnis B, Kwiatkowski D, Su X, White N, Ringwald P, Plowe CV. ARC3: A genome-wide association study of the genetic basis of parasite clearance rate following treatment with artemisinins. American Society of Tropical Medicine and Hygiene Annual Meeting, December 2011, Philadelphia, PA. 4. Jacob CG* , Miotto O, Takala-Harrison S, Clark T, Cummings M, Dondorp A, Fukuda M, Nosten F, Noedl H, Imwong M, Bethell D, Se Y, Lon C, Tyner S, Saunders D, Socheat D, Pyae Phyo A, Starzengruber P, Swoboda P, Cerqueira G, Silva JC, Arze C, Ricklefs S, Porcella S, Adams M, Kenefic L, Campino S, Auburn S, Manske M, MacInnis B, Kwiatkowski D, Su X, White N, Ringwald P, Plowe CV.