AIDS 2006 prelim matter 15/8/06 15:44 Page i 5th International Conference 29 August – 1 September 2006 Amsterdam, Netherlands Abstract book The correct citation for an abstract is: Authors. Title. Antiviral Therapy 2006; 11 (Suppl 2): Abstract number. Photograph of ‘Gables of Amsterdam Canal Houses’ provided by Tim Killam, www.cityboek.nl AIDS 2006 prelim matter 15/8/06 15:44 Page ii ANTIVIRAL THERAPY EDITORS-IN-CHIEF EMERGING VIRUSES AND BIODEFENCE PRE-CLINICAL HIV Clarence J Peters Amalio Telenti Joep MA Lange University of Texas Medical Branch Institute of Microbiology, CHUV Center of Poverty-related Communicable Diseases 3.146 Keiller Building 1011 Lausanne, Switzerland Academic Medical Centre 301 University Boulevard Fax: +41 21 314 4095 University of Amsterdam, Meibergdreef 9 (T-125) Galveston, TX 77555-0609, USA 1105 AZ Amsterdam, the Netherlands Fax: +1 409 747 2429 PAPILLOMAVIRUSES Tel: +31 20 314 9300 William Bonnez Fax: +31 20 314 9399 HEPATITIS VIRUSES Infectious Diseases Unit - Box 689 E-mail: [email protected] Stephen Locarnini University of Rochester Medical Center Victorian Infectious Diseases Reference 601 Elmwood Avenue Douglas D Richman Laboratory Rochester, NY 14642, USA University of California, San Diego WHO Collaborating Centres for Virus Reference Fax: +1 585 442 9328 Departments of Pathology and Medicine 0679 and Research, and Biosafety 9500 Gilman Drive, La Jolla 10 Wrekyn Street, North Melbourne 3051, RESPIRATORY VIRUSES CA 92093-0679, USA Victoria, Australia Frederick G Hayden Tel: +1 858 552 7439 Fax: +61 3 9342 2666 Department of Internal Medicine Fax: +1 858 552 7445 Box 473, University of Virginia E-mail: [email protected] CLINICAL HIV Health Sciences Center, Charlottesville Peter Reiss VA 22908, USA National AIDS Therapy Evaluation Centre Fax: +1 434 924 9065 SECTION EDITORS Academic Medical Centre University of Amsterdam, Pietersbergweg 9 HERPESVIRUSES 1105 BM Amsterdam, the Netherlands Richard J Whitley Fax: +31 20 314 9399 University of Alabama at Birmingham School of Medicine, Division of Clinical Virology Joe Eron 616 Children’s Hospital University of North Carolina at Chapel Hill 1600 7th Avenue South, Birmingham 211a W Cameron St, CB 7030, APCF AL 35233-0001, USA Chapel Hill, NC 27599-7030, USA Fax: +1 205 934 8559 Fax: +1 919 966 1576 EDITORIAL BOARD Fred Y Aoki (Winnipeg, Canada) José M Gatell (Barcelona, Spain) Luc Perrin (Geneva, Switzerland) Lawrence Banks (Trieste, Italy) Lutz Gissmann (Heidelberg, Germany) Thierry Poynard (Paris, France) Karen K Biron (Research Triangle Park, NC, USA) Scott M Hammer (Boston, MA, USA) Jonathan M Schapiro (Tel Hashomer, Israel) Michael Bray (Bethesda, MD, USA) Martin Hirsch (Boston, MA, USA) Raymond F Schinazi (Atlanta, GA, USA) David M Burger (Nijmegen, the Netherlands) Stanley M Lemon (Galveston, TX, USA) Robert T Schooley (Denver, CO, USA) Jeffrey I Cohen (Bethesda, MD, USA) Yun-Fan Liaw (Taipei, Taiwan) John J Treanor (Rochester, NY, USA) Ann Collier (Seattle, WA, USA) Susan J Little (San Diego, CA, USA) Stefano Vella (Rome, Italy) Robert B Couch (Houston, TX, USA) Anna Lok (Ann Arbour, MI, USA) Patrick Yeni (Paris, France) Janet Englund (Houston, TX, USA) Michael Peter Manns (Hannover, Germany) Delia Enria (Pergamino, Argentina) Patrick Marcellin (Clichy, France) Michael Gale (Dallas, TX, USA) Julio SG Montaner (Vancouver, Canada) EDITORIAL OFFICE MANAGING EDITOR International Medical Press Tel: +44 20 7398 0700 Stephen Cameron 36 St Mary at Hill Fax:+44 20 7398 0701 London EC3R 8DU E-mail: [email protected] MEDICAL EDITOR UK http://www.intmedpress.com Oliver Childs PRODUCTION EDITORS Emdadur Rahman, Will Fox ii Antiviral Therapy 11, Supplement 2 AIDS 2006 prelim matter 15/8/06 15:44 Page iii CONTENTS Sponsors iv Committees v Programme at a Glance vi Abstract Listing ix Abstracts 1 Notes AIDS Vaccine 2006 iii AIDS 2006 prelim matter 15/8/06 15:44 Page iv Main Sponsors The organizing committee of the AIDS Vaccine 2006 Conference would like to acknowledge the following sponsors for their support: National Institutes of Health/Office of AIDS Research www.nih.gov Bill & Melinda Gates Foundation www.gatesfoundation.org National Institute of Allergy and Infectious Diseases www.niaid.nih.gov Dutch Ministry of Foreign Affairs www.minbuza.nl The World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) through their WHO-UNAIDS HIV Vaccine Initiative (HVI) www.who.int/vaccines/givs Centers for Disease Control and Prevention www.cdc.gov Other Sponsors AIDS Fonds, The Netherlands www.aidsfonds.nl French National Agency for Research on AIDS and Viral Hepatitis www.anrs.fr International AIDS Vaccine Initiative (IAVI) www.iavi.org Sanofi Pasteur www.sanofipasteur.com F. Hoffmann-La Roche Ltd www.roche-hiv.com Municipality of Amsterdam www.amsterdam.nl GlaxoSmithKline www.gsk.com Elizabeth Glaser Pediatric AIDS Foundation www.pediaids.org The Wellcome Trust www.wellcome.ac.uk Crucell N.V. www.crucell.com The Merck Research Laboratories www.merck.com/mrl iv Antiviral Therapy 11, Supplement 2 AIDS 2006 prelim matter 15/8/06 15:44 Page v ORGANIZING COMMITTEE Ben Berkhout Deborah Birx Susan Buchbinder José Esparza Jaap Goudsmit Jonathan Heeney Peggy Johnston Pontiano Kaleebu Michel Kazatchkine Marie-Paule Kieny Wayne Koff Joep Lange (Chair) Peter Liljeström Marta Marthas Timothy Mastro Bonnie Mathieson Frank Miedema Gary Nabel Helen Rees Praphan Phanuphak Hanneke Schuitemaker Rafick-Pierre Sékaly Mitchell Warren Yiming Shao SCIENTIFIC PROGRAMME COMMITTEE Alash'le Abimiku Rafi Ahmed Brigitte Autran Gunnel Biberfeld Dennis Burton Sal Butera David Cooper Larry Corey Anthony DeVico Clive Gray Barbara Ensoli Pat Fast Thomas Folks Genoveffa Franchini Beatrice Hahn Nancy Haigwood Scott Hammer Barton Haynes Linda Klavinskis David Knipe Bette Korber Richard Koup Norman Letvin Yves Levy Jeffrey Lifson Fred Mhalu John Mascola Souleymane Mboup Francine McCutchan Julie McElrath David Montefiori Lynn Morris Saladin Osmanov Julie Overbaugh Steve Patterson Giuseppe Pantaleo Louis Picker Punnee Pitisuttithum Nina Russell Jeffrey Safrit Quentin Sattentau Gabriella Scarlatti John Shiver Charles Vitek Robin Weiss Carolyn Williamson Hans Wolf LOCAL PROGRAMME COMMITTEE Frans van den Boom Roel Coutinho Sam Gobin Ab Osterhaus Kees Rümke Janneke van de Wijgert CONFERENCE COORDINATOR Jacqueline van Tongeren AIDS Vaccine 2006 Conference Secretariat The Conference Organisation of the AMC, Nicolaes Tulp Institute Academic Medical Center, University of Amsterdam P.O. Box 23213, 1100 DS, Amsterdam, The Netherlands E-mail: [email protected] Telephone: +31 20 566 8585 Fax: +31 20 696 3228 Website: www.aidsvaccine06.org AIDS Vaccine 2006 v AIDS 2006 prelim matter 15/8/06 15:44 Page vi PROGRAMME AT A GLANCE Time Tuesday 29 August 2006 13.00 – Registration (Onyx Lounge) Mounting Posters (Diamond/Topaz Lounge) 15.30 – 17.45 Opening Session (Auditorium) 17.45 – 20.30 Canal Boat trip & Welcome Reception (Maritime Museum) Wednesday 30 August 2006 08.30 – 10.00 Plenary Session (Auditorium) 10.00 -10.30 Coffee & Tea Break (Lounge Auditorium) 10.30 – 12.30 Oral Abstract 1 Oral Abstract 2 Oral Abstract 3 HIV Transmission/ Vaccine Antigen Prophylactic Vaccine Trials Acute HIV Infection/ Selection & Design (Room B) Innate & Mucosal Immunity (Room A) (Auditorium) 12.30 – 13.30 Lunch Break (Lounge Auditorium) 13.30 – 15.30 Symposium 1 Symposium 2 Basic Findings and their Novel Vectors and Impact on Vaccine Design Vector Combinations (Room A)* (Auditorium) 15.30 – 16.00 Coffee & Tea Break (Lounge Auditorium) 16.00 – 18.00 Symposium 3 Symposium 4 Streamlining Vaccine Development T Cell and Innate for HIV and Other Diseases Immunity (Auditorium) (Room A) * 18.00 – 19.00 Poster Presentations Topic 9 (A–D) (Topaz Lounge) *The live presentation will be in Room A, overflow in Room B vi Antiviral Therapy 11, Supplement 2 AIDS 2006 prelim matter 15/8/06 15:44 Page vii Time Thursday 31 August 2006 08.00 – 10.00 Plenary Session (Auditorium) 10.00 – 10.30 Coffee & Tea Break (Lounge Auditorium) 10.30 – 12.30 Oral Abstract 4 Oral Abstract 5 Oral Abstract 6 T Cell Immunity B Cell Immunity Clinical Trial Site Development/ (Auditorium) (Room A) Social, Ethical, Access and Regulatory Issues (Room B) 12.30 – 13.30 Lunch Break (Lounge Auditorium) 12.30 – 13.00 Special Lunch Time Lecture (Room A) 13.30 – 15.30 Symposium 5 Symposium 6 Neutralizing Antibodies Animal Models and (Auditorium) Correlates of Immunity (Room A)* 15.30 – 16.00 Coffee & Tea Break (Lounge Auditorium) 16.00 – 18.00 Symposium 7 Symposium 8 T Cell Vaccine Epidemiology/ Development with focus Clinical Trials Issues on T Cell Responses (Room A)* (Auditorium) 18.00 – 19.00 Poster Presentations Topic 1-8 & Topic 10-14 (Diamond Lounge) Friday 1 September 2006 08.30 – 10.00 Plenary Session (Auditorium) 10.00 – 10.30 Coffee & Tea Break (Lounge Auditorium) 10.30 – 12.30 Oral Abstract 7 Oral Abstract 8 Oral Abstract 9 Immune Escape Vaccine Delivery Animal Models/Live Attenuated (Auditorium) Methods/Adjuvants Vaccines/Therapeutic Vaccination (Room A) (Room B) 12.30 – 13.30 Lunch Break (Lounge Auditorium) 13.30 – 15.30 Symposium 9 Symposium 10 Large Scale Production Therapeutic Vaccine and Delivery Issues Trials (Auditorium) (Room A)* 15.30 – 16.00 Coffee & Tea Break (Lounge Auditorium) 16.00 – Closing Session (Auditorium) *The live presentation will be in Room A, overflow in Room B AIDS Vaccine 2006 vii AIDS 2006 prelim matter 15/8/06 15:44 Page viii AIDS 2006 prelim matter 15/8/06 15:44 Page ix ABSTRACT LISTING ORAL