University of Washington Department of Orthopaedics and Sports Medicine 2007 Research Report UNIVERSITY OF WASHINGTON Department of Orthopaedics and Sports Medicine 2007 Research Report Department of Orthopaedics and Sports Medicine University of Washington Seattle, WA 98195 EDITOR: Frederick A. Matsen III, M.D. Fred Westerberg DESIGN & LAYOUT: Fred Westerberg Cover Illustration: “Red Tree, Yellow Sky” by Georgia O’Keefe, 1952. Museum of Fine Arts, Boston, MA, USA Photograph©2007 Museum of Fine Arts, Boston Contents Foreword ...................................................................................................................... 1 Department of Orthopaedics and Sports Medicine Faculty .................................................... 2 Visiting Lecturers ........................................................................................................... 6 Msx-1 and Ki67 Expression in Human Fetal Digits After Tip Amputation ................................. 7 Brendan Inouye, Abby L. Navratil, B.S., Marcia L. Usui, B.S., Robert Underwood, B.F.A., Philip Fleckman, M.D., Rima Kulikauskas, B.S., and Christopher Allan, M.D. A Gene-Therapy Approach to Suppressing EWS/FLI-1 Leads to Cellular Senescence Through Rb Family Dependent and Independent Pathways ..................................................................10 Hsien-Ming Hu, Ph.D., Anna Zielinska-Kwiatkowska, M.S., Daniel Wu, M.D., Ph.D., Liu Yang, Ph.D., and Howard Chansky, M.D. Inhibitor of DNA Binding Protein Id2 Negatively Regulates Chondrogenic Differentiation of ATDC5 Cells .................................................................................................................12 Liu Yang, Ph.D., Xiaoyun Ma, Ph.D., Anna Zielinska-Kwiatkowska, M.D., and Howard A. Chansky, M.D. Post-Translational Overmodification of Collagen Expressed by SAOS-2 Osteoblast-Like Cells ....14 Russell J. Fernandes Ph.D., Michael A. Harkey Ph.D., and David R. Eyre Ph.D. Identification of Mimecan: A Small Leucine-Rich Proteoglycan in Bovine Epiphyseal Cartilage ..17 Jiann-Jiu Wu, Ph.D., Mary Ann Weis, B.S., Bryan G. Carter, B.S., and David R. Eyre, Ph.D. Augmenting Bone Mass with Low Magnitude Loading .........................................................19 Sandra L. Poliachik, M.D., Sarah E. Warner, Ph.D., Dewayne Threet, B.S., Sundar Srinivasan, Ph.D., and Ted S. Gross, Ph.D. Cadaveric Simulation of a Pes Cavus Foot ........................................................................21 S. Bradley Daines, B.A., Eric S. Rohr, M.S., Andrew P. Pace, B.S., Michael J. Fassbind, M.S., Bruce J. Sangeorzan, M.D., and William R. Ledoux, Ph.D. Intramedullary Reaming for Press-Fit Fixation of a Humeral Component Removes Cortical Bone Asymmetrically ............................................................................................................24 Michael Lee, M.D., Caroline Chebli, M.D., Doug Mounce, M.S., Alexander Bertelsen, P.A.-C, Michael Richardson, M.D., and Frederick A. Matsen III, M.D. The Effect of Associated Injuries on the Functional Outcome of Distal Humeral Fractures ........27 James L. Howard, M.D., M.Sc., F.R.C.S.C., Chad P. Coles, M.D., F.R.C.S.C., Julie Agel, M.A., A.T.C., and David P. Barei, M.D., F.R.C.S.C. Commercially-Funded and US-Based Research is More Likely to be Published; Good-Quality Negative Studies are Not ...............................................................................................31 Joseph R. Lynch, M.D., Mary R.A. Cunningham, M.D., Winston J. Warme, M.D., Douglas C. Schaad, Ph.D., Fredric M. Wolf, Ph.D., and Seth S. Leopold, M.D. The Detailed Anatomy of the 1,2 Intercompartmental Supraretinacular Artery for Vacularized Bone Grafting of Scaphoid Nonunions ..............................................................................34 Thanapong Waitayawinyu, M.D., Cassandra Robertson, M.D., and Thomas E. Trumble, M.D. Stabilization of the Posteromedial Fragment in Bicondylar Tibial Plateau Fractures: A Mechanical Comparison of Locking and Non-Locking Single and Dual Plating Methods ............................37 Brad Yoo, M.D., Daphne M. Beingessner, M.Sc., M.D., F.R.C.S.C., and David P. Barei, M.D., F.R.C.S.C. Comparison of Minimally-Invasive and Traditional Medial-Parapatellar Surgical Approaches to Total Knee Arthroplasty: Evaluation of the Learning Curve and Early Post-Operative Recovery .41 Jason King, M.D., M.P.H., Daniel L. Stamper, P.A.-C, Douglas C. Schaad, Ph.D., and Seth S. Leopold, M.D. Scapholunate Interosseous Ligament Reconstruction: Results with a Modified Brunelli Technique Versus Four-Bone Weave ...............................................................................................45 Annie C. Links, M.D., Simon H. Chin, M.D., Thanapong Waitayawinyu, M.D., and Thomas E. Trumble, M.D. Component Position in Two-Incision Minimally Invasive Total Hip Arthroplasty Compared to Standard Total Hip Arthroplasty ......................................................................................49 Susan L. Williams, M.D., Casey Bachison, James Michelson, M.D., and Paul A. Manner, M.D., F.R.C.S.C. Surgical Approach and Fixation of Unicondylar Medial Hoffa Fractures: A Technical Paper ........52 Darius G. Viskontas, M.D., F.R.C.S.C., David Barei, M.D., F.R.C.S.C., Lisa A. Taitsman, M.D., Robert Dunbar, M.D., and Sean E. Nork, M.D. Isolated Locked Plating of Periprosthetic Femoral Fractures Associated with Stable Hip Arthroplasties ..............................................................................................................54 Ginger Bryant, M.D., David Barei, M.D., F.R.C.S.C., Lisa A. Taitsman, M.D., Daphne Beingessner, M.D., F.R.C.S.C., Sean E. Nork, M.D., and M. Bradford Henley, M.D., M.B.A. Injuries in Youth vs. College Women’s Soccer ...................................................................57 John W. O’Kane, M.D. and Melissa A. Schiff, M.D., M.P.H. Radiographic Quantification and Analysis of Dysmorphic Upper Sacral Osseous Anatomy and Iliosacral Screw Insertions .............................................................................................59 Joseph M. Conflitti, M.D., Matt L. Graves, M.D., and M.L. Chip Routt, Jr., M.D. Early Outcomes Following ACL Reconstruction Using Soft-Tissue Grafts Passed Across Open Physes ........................................................................................................................62 Gregory A. Schmale, M.D., Christopher Y. Kweon, M.D., and Roger V. Larson, M.D. SRS Surgeon Members Risk for Thyroid Cancer: Is it Increased? ........................................65 Theodore A. Wagner, M.D., Sue-Min Lai, Ph.D., M.S., M.B.A., and Marc A. Asher, M.D. Graduating Residents ....................................................................................................68 Incoming Residents ......................................................................................................69 ACEs and Fellows .........................................................................................................71 Research Grants ...........................................................................................................73 Department Publications 2006-2007 ...............................................................................75 Contributors to Departmental Research and Education .......................................................78 Alumni ........................................................................................................................80 Endowments ................................................................................................................82 Foreword his year’s research report cover is graced with Specifically, our vision is to become the best possible Georgia O’Keeffe’s Red Tree, Yellow Sky (1952) resource for research, education and clinical care for Tthat hangs in the American Moderns Gallery of the individuals whose lives have been compromised by Museum of Fine Arts in Boston (465 Huntington Avenue). problems related to their bones, joints and spine. Our O’Keeffe (1887-1986) is one of the best known American foundation in sports medicine teaches us that each artists, presenting, as in this painting, crisply painted patient has an athlete within them. Inspiring that organic objects against an environmental background. athlete to participate actively in their rehabilitation Her art first won recognition in 1908 when the 21- program is essential to a rapid and full recovery. Our year-old artist presented Dead Rabbit with Copper Pot, foundation in science teaches us that we can always which earned her a scholarship to attend the outdoor improve on the current understanding, evaluation summer school of the Art Student’s League. In 1924, and treatment of musculoskeletal disorders. Having she married famed photographer Alfred Stieglitz, who chaired this Department for 20 years now, I am thrilled featured his wife in many, often revealing, photographs. with the relentless efforts of the faculty to continually In 1929 she moved to New Mexico eventually settling raise the standard of care and with the profound in Abiquiu near Ghost Ranch, which inspired many of effect these efforts have had on the practice of our her best known paintings, including Ram’s Head White specialty. Our foundation as educators enables us to Hollyhock and Little Hills. In 1946 she became the share these advances in knowledge with our residents, first woman to be featured in a solo retrospective at fellows and practicing physicians so that the benefit is the