Sleep Medicine 16 (2015) S1 Contents lists available at ScienceDirect Sleep Medicine journal homepage: www.elsevier.com/locate/sleep WASM 2015 editorial Dear Colleagues and Friends, character and reach of WASM in collaboration with the knowledge On behalf of the World Association of Sleep Medicine (WASM) of the local Korean Society of Sleep Medicine bring the best of sleep and the Korean Society of Sleep Medicine (KSSM), we are delight- medicine to Korea. Your involvement in this congress will be greatly ed to welcome you to our joint congress: the 6th World Congress valued. You may learn and also share knowledge and skills that will on Sleep Medicine, from March 21 to 25, 2015 at Seoul Korea. The advance sleep health around the world. We hope that you’ll enjoy congress provides an international discussion forum of sleep pro- the science, learning, collegiality, and social events at our world sleep fessionals from the entire world. It focuses particularly on the conference in this historic city with great food, culture, art, and music. interdisciplinary character of our field. Sleep clinicians, technolo- Welcome to Seoul! gists, trainees, educators and scientists from around the world will Best regards, meet here to advance knowledge on sleep science; sleep in public health; sleep health; and the sleep–wake disorders, diagnosis, and Allan O’Bryan * treatments. We seek to maximize learning both from formal pre- World Association of Sleep Medicine, 3270 19th St NW, Suite 110, sentations by leading experts in their fields and from informal Rochester, MN 55901, USA discussion groups emphasizing opportunities for your participa- *Tel.: +1 507 206 1235; fax: +1 877 659 0760. tion. The social events and the Asian culture of Korea support E-mail address: [email protected] productive professional and personal interactions. The global Available online 26 February 2015 http://dx.doi.org/10.1016/j.sleep.2015.02.525 1389-9457/Published by Elsevier B.V. Sleep Medicine 16 (2015) S2–S199 Contents lists available at ScienceDirect Sleep Medicine journal homepage: www.elsevier.com/locate/sleep Abstracts for the 6th World Congress on Sleep Medicine, 23 March to 25 March 2015 Altered sleep architecture in autosomal dominant Acknowledgements: Department of Neurology, NIMHANS, De- spinocerebellar ataxias: A polysomnographic based study partment of Neurophysiology, NIMHANS. S. Donilparthi 1,R.Yadav1, A. Sasidharan 2,P.Pal1, S. Jain 3, B. Kutty 2 http://dx.doi.org/10.1016/j.sleep.2015.02.003 1 Department of Neurology, NIMHANS, Bangalore, India 2 Department of Neurophysiology, NIMHANS, Bangalore, India 3 Molecular Genetics Laboratory, NIMHANS, Bangalore, India Diagnosing REM sleep behaviour disorder in patients with Parkinson’s disease: The role of screening questionnaires and of Introduction: Spinocerebellar ataxias (SCAs), are tri nucleotide measures of REM sleep without atonia repeat length progressive neurodegenerative disorders in which the M. Figorilli 1,R.Ferri2, B. Pereira 3, P. Beudin 4, F. Marrosu 5, cerebellum slowly degenerates, often accompanied by degenera- M. Puliggheddu 5, F. Durif 6, M. Fantini 6 tive changes in the brainstem. Sleep disturbances have been reported 1 Sleep Disorder Center, Department of Public Health & Clinical and in few studies. Molecular Medicine, University of Cagliari, Italy Materials and methods: Objective: To identify and to character- 2 Department of Neurology I.C., Oasi Institute for Research on Mental ize the sleep disturbances in patients with genetically positive Retardation and Brain Aging (IRCCS), Italy spinocerebellar ataxias (SCA 1, 2, 3). Methods: Patients with pro- 3 Biostatistics Unit (DRCI) Clermont-Ferrand, France gressive ataxia were identified and assessed clinically. All the patients 4 Neurology Department, Chu Clermont-Ferrand, France were interviewed with sleep questionnaire. Disease severity was 5 Sleep Disorder Center, Department of Public Health & Clinical and measured with International Ataxia Rating Scale (ICARS) scale. Sleep Molecular Medicine, Italy quality was assessed with Pittsburgh Sleep Quality Index (PSQI), 6 EA 7980, UFR Medicine, University of Clermont, Clermont-Ferrand, Mayo Sleep Questionnaire (MSQ), Epworth Sleepiness Scale (ESS). France Genetically confirmed cases (20 patients) underwent overnight polysomnography (PSG) using 40 channel Galileo Mizar-40 Polysomnography sytem (EB Neuro, Italy). The sleep scoring was Introduction: To assess the sensitivity and specificity of both the carried out according to AASM-2012 using POLYMAN v1.15 (Marco REM sleep behaviour disorder (RBD) single-question screen (RBD1Q) Roessen and Bob Kemp) and sleep variables were analysed across [1] and the RBD-Screening Questionnaire (RBDSQ) [2], as well as sleep cycles using custom scripts written in MATLAB 2012b of measures of REM sleep without atonia (RSWA) assessed with three (Mathworks, USA). different methods, in patients with Parkinson’s disease (PD). = Results: Patients of SCA1, 2, 3 (n = 20; 11 males) were recruited. Materials and methods: Sixty non-demented PD patients (M 37; ± SCA1 = 8; SCA2 = 7; SCA3 = 5; Mean age = 35.49 ± 7.75; Mean mean age: 64 8 years) consecutively evaluated at a movement dis- ICARS = 35.15 ± 18.75; Mean PSQI =3.8 ± 3.6, Mean ESS =2.1 ± 1.7. All order center, filled out both RBD1Q and RBD-SQ, before undergoing patients (8/8) of SCA1 reported no sleep distrubances; 3/7 pa- a full-night video-polysomnographic recording. RSWA was evalu- tients of SCA 2 reported delayed sleep onset; 3/5 patients of SCA3 ated using the Montreal method [3] (% tonic 30-s epochs and % 2-s reported delayed sleep onset and intermittent awakening. And none mini-epochs containing phasic chin EMG activity), the SINBAR [4] of them gave a history suggestive of REM sleep behaviour disor- (% 30-s epochs containing any chin or bilateral Flexor Superficialis der (RBD), rest less leg syndrome (RLS), excessive day time Digitorum (FSD) EMG activity) and the automatic Atonia Index [3]. somnolence (EDS). Polysomnographic analysis showed significant The comparison of these three methods was possible in 32 patients. alteration of sleep architecture predominantly affecting REM sleep Results: RBD was diagnosed in 36 patients following the ICSD-3 ≥ states. Average Sleep Efficiency = 75.6 ± 17.6; N1% = 17.6 ± 12; criteria, including the presence of 27% of 30-s epochs containing N2% = 52 ± 14.6; N3% = 24.5 ± 12.5; REM% = 5.6 ± 6.8. Absent REM any chin or FSD EMG activity. Sensitivity of the RBD-1Q and of the = = sleep states in 70% of SCA2 patients, 60% of SCA3 patients, present RBD-SQ was 55.9% (ROC 0.79) and 52.9% (ROC 0.78), while speci- in all patients in SCA1 but with significant reduction. There is neg- ficity was 90.9% for RBD-1Q and 81.8% for RBDSQ. The simultaneous ative correlation between disease severity (ICARS) and REM use of both questionnaires increases the sensitivity (67.6%, = percentage (p = 0.028). ROC 0.84) without modifying the specificity (76.2%). Taking ICSD-3 Conclusion: In SCAs as the degeneration progresses brain stem RSWA criteria as a reference, the tonic parameters of two visual structures are involved apart from the cerebellum. The more severe methods, namely the Montreal % tonic chin 30-s epochs and the affection of REM sleep States in SCA2 patients and SCA3 supports SINBAR % 30-s epochs containing any chin/FSD activity, showed 100% = early affection of brain stem structures. This needs further explo- sensitivity, 76.9% specificity and ROC 0.93. Atonia Index per- = = ration by neuroimaging and pathology studies. formed slightly lower, with sensitivity 94.7%, specificity 69.2% and ROC = 0.84. The phasic parameters performed significantly worse. Abstracts/Sleep Medicine 16 (2015) S2–S199 S3 The inclusion of FSD does not increase the performance obtained Center for Research Resources and the National Center for Advanc- with the chin alone. ing Translational Sciences, National Institutes of Health, through Conclusion: Screening questionnaires showed good specificity but Grant Number 1 UL1 RR024150-01. low sensitivity; conversely, visual and automatic evaluation of RSWA showed high sensitivity and good specificity for RBD in PD pa- http://dx.doi.org/10.1016/j.sleep.2015.02.005 tients. PD patients might underestimate their RBD during sleep and/ or they might show relatively frequent RSWA without fulfilling the diagnostic criteria for RBD. Motor and non-motor features of Parkinson’s disease in idiopathic REM sleep behaviour disorder References M. Rolinski 1,M.Lawton2,S.Evetts1, F. Baig 1, C. Ruffmann 1, [1] Postuma, et al. Mov Disord 2012. C. Mackay 1, T. Quinnell 3, Z. Zaiwalla 4, Y. Ben-shlomo 2,M.Hu1 [2] Stiasny-Kolster, et al. Mov Disord 2007. 1 University of Oxford, UK [3] Ferri, et al. Sleep Med 2014. 2 University of Bristol, UK [4] Frauscher, et al. Sleep 2012. 3 Papworth Hospital NHS Trust, UK 4 Oxford University Hospitals NHS Trust, UK http://dx.doi.org/10.1016/j.sleep.2015.02.004 Introduction: In some, REM sleep behavior disorder (RBD) is thought to represent the prodromal stage of Parkinson’s disease (PD). Antidepressants increase REM sleep muscle tone in patients with To assess this, we endeavored to elucidate the motor and non- and without REM sleep behavior disorder motor characteristic of RBD, in comparison with healthy controls S. McCarter 1, E. St. Louis 2, D. Sandness 1, K. Arndt 3, M. Erickson 3, and patients with early drug-naïve PD, accounting for potential G. Tabatabai 1,B.Boeve4, M. Silber 4 genetic confounders. 1 Mayo Clinic Center for Sleep Medicine, USA Materials and methods: Patients with idiopathic RBD were re- 2 Department of Neurology and Medicine, Mayo Clinic Center for cruited from the sleep disorders clinic at the John Radcliffe Hospital, Sleep Medicine, USA Oxford and the Papworth Hospital, Cambridge. The diagnosis of RBD 3 Cornell College, USA was made on the basis of polysomnographic evidence according to 4 Department of Neurology, Mayo Clinic Center for Sleep Medicine, standard International Classification of Sleep Disorders-II criteria USA by a consultant specialising in sleep disorders.