© National HIV Curriculum PDF created September 30, 2021, 2:34 pm Nelfinavir (Viracept) Table of Contents Nelfinavir Viracept Summary Drug Summary Key Clinical Trials Resistance Key Drug Interactions Drug Summary Nelfinavir is a protease inhibitor that was approved in 1997 and widely used as a component of combination antiretroviral therapy in the late 1990s. Subsequently, it was replaced in clinical practice with newer, more potent, and better-tolerated medications. Nelfinavir is administered without a pharmacokinetic booster and has a relatively low potency and low genetic barrier to resistance. Fortunately, most patients who developed drug resistance to nelfinavir respond to at least one of the newer HIV protease inhibitors. Nelfinavir is no longer recommended for use in antiretroviral therapy regimens and patients taking this agent should switch to a more current option. Key Clinical Trials In an early trial that compared nelfinavir to full-dose ritonavir plus background NRTIs for patients with advanced HIV (CD4 count below 200 cells/mm3), progression to AIDS or death was similar between the two arms, though more patients in the ritonavir arm discontinued treatment [CPCRA 042]. Multiple subsequent trials (some in treatment-naïve persons and some in treatment-experienced) showed that the efficacy of nelfinavir was inferior relative to other anchor antiretroviral agents, including fosamprenavir [NEAT], lopinavir- ritonavir [M98-863], and efavirenz [ACTG 384 and ACTG 388]. Resistance For a listing of the most common clinically significant mutations associated with nelfinavir (NFV) resistance, see the PI Resistance Notes on the Stanford University HIV Drug Resistance Database. Page 1/2 Key Drug Interactions For complete information on nelfinavir-related drug interactions, see the Drug Interactions section in the Nelfinavir (Viracept) Prescribing Information. © National HIV Curriculum PDF created September 30, 2021, 2:34 pm The most up to date version of this content may be obtained from: https://www.hiv.uw.edu/page/treatment/drugs/nelfinavir Page 2/2 Powered by TCPDF (www.tcpdf.org).