BioMed Research International Research on Saliva Secretion and Composition Lead Guest Editor: Elsa Lamy Guest Editors: Fernando C. e Silva and Asta Tvarijonaviciute Research on Saliva Secretion and Composition BioMed Research International Research on Saliva Secretion and Composition Lead Guest Editor: Elsa Lamy Guest Editors: Fernando C. e Silva and Asta Tvarijonaviciute Copyright © 2018 Hindawi. All rights reserved. This is a special issue published in “BioMed Research International.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Contents Research on Saliva Secretion and Composition Elsa Lamy , Fernando Capela-Silva , and Asta Tvarijonaviciute Editorial(2pages),ArticleID7406312,Volume2018(2018) The Associations between Biochemical and Microbiological Variables and Taste Differ in Whole Saliva and in the Film Lining the Tongue Yunzi Feng, Hélène Licandro, Christophe Martin, Chantal Septier, Mouming Zhao , Eric Neyraud , and Martine Morzel Research Article (10 pages), Article ID 2838052, Volume 2018 (2018) The Effect of Breed, Gender, and Acid Stimulation in Dog Saliva Proteome Sónia Lucena, Ana V. Coelho , Fernando Capela-Silva , Asta Tvarijonaviciute ,andElsaLamy Research Article (12 pages), Article ID 7456894, Volume 2018 (2018) Salivary Antioxidant Status in Patients with Oral Lichen Planus: Correlation with Clinical Signs and Evolution during Treatment with Chamaemelum nobile Asta Tvarijonaviciute , Cristina Aznar-Cayuela, Camila P. Rubio , Fernando Tecles, Jose J. Ceron , and Pia López-Jornet Research Article (5 pages), Article ID 5187549, Volume 2018 (2018) Saliva as a Future Field in Psoriasis Research Farah Asa’ad ,MarcoFiore , Aniello Alfieri , Paolo Daniele Maria Pigatto, Chiara Franchi, Emilio Berti, Carlo Maiorana , and Giovanni Damiani Review Article (6 pages), Article ID 7290913, Volume 2018 (2018) A Review of Selected Studies That Determine the Physical and Chemical Properties of Saliva inthe Field of Dental Treatment Elżbieta Kubala, Paulina Strzelecka, Marta Grzegocka, Danuta Lietz-Kijak, Helena Gronwald, Piotr Skomro, and Edward Kijak Review Article (13 pages), Article ID 6572381, Volume 2018 (2018) Salivary Biomarkers in Systemic Sclerosis Disease Zeineb Zian , Joaira Bakkach, Amina Barakat, Naima Ghailani Nourouti, and Mohcine Bennani Mechita Review Article (7 pages), Article ID 3921247, Volume 2018 (2018) The Effects of Tooth Brushing on Whole Salivary Flow Rate in Older Adults R. H. Affoo ,K.Trottier,R.Garrick,T.Mascarenhas,Y.Jang,andR.E.Martin Research Article (7 pages), Article ID 3904139, Volume 2018 (2018) Revealing the Amylase Interactome in Whole Saliva Using Proteomic Approaches Karla Tonelli Bicalho Crosara, David Zuanazzi, Eduardo Buozi Moffa ,YizhiXiao, Maria Aparecida de Andrade Moreira Machado , and Walter Luiz Siqueira Research Article (15 pages), Article ID 6346954, Volume 2018 (2018) Effects and Mechanisms of Tastants on the Gustatory-Salivary Reflex in Human Minor Salivary Glands Shizuko Satoh-Kuriwada , Noriaki Shoji, Hiroyuki Miyake, Chiyo Watanabe, and Takashi Sasano Research Article (12 pages), Article ID 3847075, Volume 2018 (2018) Oxidative Modification of Biomolecules in the Nonstimulated and Stimulated Saliva of Patients with Morbid Obesity Treated with Bariatric Surgery Katarzyna Fejfer, Piotr Buczko, Marek Niczyporuk, Jerzy R. Ładny, Hady R. Hady, Małgorzata Knaś, Danuta Waszkiel, Anna Klimiuk, Anna Zalewska, and Mateusz Maciejczyk Research Article (8 pages), Article ID 4923769, Volume 2017 (2018) Hindawi BioMed Research International Volume 2018, Article ID 7406312, 2 pages https://doi.org/10.1155/2018/7406312 Editorial Research on Saliva Secretion and Composition Elsa Lamy ,1 Fernando Capela-Silva ,1,2 and Asta Tvarijonaviciute 3 1 Instituto de Ciencias Agrarias e Ambientais Mediterranicas (ICAAM), Universidade de Evora,´ 7000-083 Evora,´ Portugal 2Departamento de Biologia, Escola de Ciencias e Tecnologia, Universidade de Evora, 7000-671 Evora, Portugal 3Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Regional Campus of International Excellence “Campus MareNostrum”, University of Murcia, 30100 Espinardo, Murcia, Spain Correspondence should be addressed to Elsa Lamy; [email protected] Received 3 June 2018; Accepted 3 June 2018; Published 26 June 2018 Copyright © 2018 Elsa Lamy et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In the last two decades, saliva gained enormous attention and One of these works, reported by A. Tvarijonaviciute et al., has become focus of a high number of studies, which resulted studied the efect of Chamaemelum nobile on the oxidative in a considerable progress in the knowledge about this stress parameters and their relationship to clinical symptoms biofuid. Te technological and analytical advances, including in patients with oral lichen planus. Te obtained results the application of omics approaches, allowed the identifca- suggest that use of Chamaemelum nobile could stabilize this tion of numerous molecules in saliva, many of which are disease, at least in medium-low severity cases. Meanwhile, presentinthisfuidinproportiontoblood.Tispermitted K. Fejfer et al. studied oxidative stress in saliva in morbid saliva to be seen as a fuid with potential for diagnosis of obese individuals, before and afer bariatric surgery. Tey diferent pathologies and physiological conditions. Moreover, observed the presence of oxidative stress-related modifca- the noninvasive nature of its collection is an advantage over tionsofsalivarybiomolecules,whichalthoughimprovedafer serum and reinforced the interest in saliva research. bariatric surgery was not completely efective in restoring Tis special issue put together high-quality research, redox balance in the oral cavity. highlighting the diversity of areas in which the study of saliva Besides its potential in the diagnosis of oral and sys- is of interest. temic diseases, saliva also has a major importance in food Ten articles, three reviews and seven original research perception. Evidences show that saliva modulates oral sen- articles, were selected for publication. Te review presented sations, such as astringency and/or basic tastes, or even by Z. Zian et al., about the use of saliva in systemic sclerosis aroma perception, suggesting that more knowledge about studies, focuses on the proteomic technologies, highlighting this biofuid composition and the factors infuencing its the potentials and limitations of using saliva as a tool of secretion should be evaluated. Under this topic, two articles diagnostic of this disease. F. Asa’ad et al. reviewed the current present results about the relationship between saliva and knowledge in saliva research applied to psoriasis, emphasis- taste: (1) S. Satoh-Kuriwada et al. evaluated the efects and ing that salivary biomarkers of this disease can be valuable mechanisms of tastes on labial minor salivary gland secretion in the future. Finally, the review of E. Kubala et al. pre- and concluded that although all basic tastes cause a gustatory- sented information about the diagnostic value of saliva as a refex secretion in minor glands, sour and umami tastes have research material, in the feld of dental treatment. Te authors amajorefect;(2)Y.Fengetal.characterizedthecomposition, concluded that more and more internists, paediatricians, in microorganisms and their metabolites, of the flm lining pharmacologists, clinical and forensic pathologists, endocri- the tongue, and highlighted the importance in considering nologists, immunologists, psychologists, and dentists are the salivary microbiome in studies evaluating relationship discovering the benefts ofered by saliva as diagnostic tool. between oral medium characteristics and taste perception. Two of the original articles presented results about On the other hand, a number of studies exist dealing salivary antioxidants variations during disease treatment. with the efects of salivary fow infuence on the analytes of 2 BioMed Research International interest. However, the possible efects that could result in salivary fow changes are less studied. With the aim of flling this gap of knowledge, R. H. Afoo et al. evaluated the efect of toothbrushingonsalivaryfowrate,comparingmanualand electrical tooth brushing. Te results indicate that the fow rate increases up to 5 minutes following this process. Tis observation was even more pronounced in older individuals. Finally, salivary proteomics was performed in two difer- ent studies. K. T. B. Crosara et al. using proteomic approaches identifed a number of interactions between amylase and other proteins present in saliva, pioneering the exploration of the vast salivary interactome. Interestingly, the authors suggest that salivary amylase may have other major func- tions besides carbohydrate digestion. Te second article was reported by S. Lucena et al. being the only one treating nonhuman saliva. In this study, it was observed that dog saliva proteome is infuenced by the breed of the animals. Moreover, acid stimulation, which is frequently used as a way of stimulating higher saliva secretion, induced changes in saliva protein composition that should be taken into account in dogs as well as other animal species and humans when designing the experiments.