BIOCHEMICAL TECHNOLOGY DIVISION Dear Fellow BIOT Members: On behalf of the BIOT Executive Committee, I would like to extend an enthusiastic welcome to all those who will be able to join us for the ACS Fall National Meeting in Boston. Program co- chairs Wilfred Chen, Bill Wang and Anurag Rathore have done an outstanding job of organizing the technical program, including over 40 sessions that comprise nearly 500 poster and oral presentations during the meeting. I want to thank Wilfred, Bill and Anurag for putting together a fantastic meeting, as well as thank the session organizers and speakers and attendees for making these meetings successful. Highlights of the Boston meeting include a special set of sessions developed on topics related to several emerging areas such as Stem Cells, Bioenergy, and Nanobiotechnology. These sessions will supplement our historically strong program in the areas of fermentation, cell culture, purification, and product characterization in biotechnology. Another series of sessions will focus on issues particularly relevant to commercialization of biotechnology products. For those of you interested in becoming involved in future meeting programming, I encourage you to attend the programming meeting on Tuesday. Remember that the organization and success of the meeting are based on a network of volunteers who give of their own personal time. We appreciate any time you can give to make the organization better for you and your colleagues. The success of BIOT programming depends on the donations it receives from supporting companies. We thank all of the organizations that have contributed to BIOT financially. These contributions are used to partially subsidize meeting expenses such as speaker registrations and travel support. These registrations are also used for providing some registration support for students and for us to organize special events during the meeting. Beyond programming, there are many ways you can contribute to BIOT. The business of BIOT is also volunteer-run and we welcome your help! The executive committee is responsible for ensuring the continuing success of BIOT. In particular, I want to acknowledge the hard work of Anne Robinson (Past Chair), Erik Fernandez (Chair-Elect), Nedim Altaras (Secretary), Hari Pujar (Treasurer), Weichang Zhou (Awards Coordinator), Kent Goklen (Communications Coordinator), Claire Komives (Newsletter Editor), Mark Marten (Long Range Program Chair), Arindam Bose, Fred Heineken, Eliana Clark, and Sharon Shoemaker (Councilors), David Block, Ilse Blumentals, Paul Mensah (Alternate Councilors), Collette Ranucci & Jayanth Sridhar (Membership). Find out more about BIOT at the Business meeting on Wednesday or visit www.acsbiot.org. I encourage you to consider becoming involved to meet new colleagues and help BIOT to continue to have a positive impact on our scientific community. Best Regards, Dana Andersen BIOT Chair 2007 i Acknowledgements from the Program Chairs We would like to take this opportunity to thank all the volunteers who worked tirelessly and the industrial sponsors who supported the meeting in order to make this possible. We would like to acknowledge all the session chairs and our symposium coordinators (Dana Andersen and Sarah Harcum for the upstream area, Steve Cramer and Ajoy Velayudhan for the downstream area, John Carpenter and Jerry Sparks for the biophysical and biomolecular area, Wei-Shou Hu and Peter Zandstra for the stem cell area, Ranjan Srivastava and Huimin Zhao for the emerging technologies area, and Raghavan Venkat and Brian Kelley for the commercialization area). We also need to thank the support by Richard Love and Laura Melohn from ACS. Mostly importantly, we would like to thank Mark Marten, our long-range program coordinator, for his invaluable support throughout the whole process. As you enjoy the meeting, please take a moment to thank all those who made this BIOT program possible. We encourage you to continue your support of the BIOT program when Ranjan Srivastava and Anurag Rathore organize the Fall 2008 ACS meeting in Philadelphia. Wilfred Chen, William Wang and Anurag Rathore 2007 BIOT Program Chairs The Biochemical Technology Division of ACS gratefully acknowledges the financial support of these industry leaders in biotechnology. (list is current as of time of publication) Amgen Biogen Idec BioProcess International Bristol-Myers Squibb Centocor EMD GE Healthcare Genentech Genzyme GlaxoSmithKline HGS Lilly MedImmune Merck Novo Nordisk PDL BioPharma Pall Life Sciences Pfizer Tosoh Wyeth BioPharma ii Table of Contents Letter from BIOT Chair....................................................................................................... i Acknowledgement from Program Chairs ........................................................................... ii Divisional Awards ............................................................................................................. iv Divisional Events & Meetings........................................................................................... ix Convention & Meeting Map ................................................................................................x Program by Day – Sunday ...................................................................................................1 BIOT Reception Information...............................................................................................2 Program by Day – Monday................................................................................................19 Program by Day – Tuesday................................................................................................35 Program by Day – Wednesday ..........................................................................................53 Program by Day – Thursday............................................................................................119 Author Index ....................................................................................................................137 Boston’s Transportation System Information..................................................................143 iii BIOT Division Awards 2007 Weichang Zhou, ACS BIOT Awards Chair The Biochemical Technology (BIOT) Division of the American Chemical Society (ACS) will present six division awards at the ACS national meeting in Boston, Massachusetts, August 19-23, 2007. These awards are the David Perlman Lecture, the Marvin J. Johnson Award, the James M. Van Lanen Distinguished Service Award, the Industrial Biotechnology Award, Alan S Michaels Award for the Recovery of Biological Products, and Young Investigator Award. In addition, the 2006 W.H. Peterson Award and Elmer Gaden Award will also be presented in this year’s BIOT division program. The Awards selection process starts with nominations by our division members. Nomination packages are reviewed and judged by individual selection committees, which decide the winner for the Awards. Details about these Awards, their nomination and selection process can be found at our division website: http://membership.acs.org/b/biochem/awards.html. The David Perlman Lecture The BIOT division selected Susan Lindquist, Member of the Whitehead Institute for Biomedical Research, Professor of Biology at Massachusetts Institute of Technology (MIT), and a Howard Hughes Medical Institute investigator to deliver this year's Perlman Lecture. This award, which is sponsored by Genzyme Corp., recognizes many of Professor Lindquist's achievements including her contributions in the area of protein folding and nanotechnology. In particular, her research provided strong evidence for a new paradigm in genetics based upon the inheritance of proteins with new, self-perpetuating shapes rather than new DNA sequences. Her award lecture titled "Prion Proteins and How They Fold" is scheduled for August 19. Professor Lindquist is a member, and former Director, of the Whitehead Institute for Biomedical Research. Previously she was the Albert D. Lasker Professor in the Department of Molecular and Cellular Biology at the University of Chicago. She received her PhD in Biology from Harvard in 1976 and was a postdoctoral fellow of the American Cancer Society. She was elected to the National Academy of Sciences in 1997 and the Institute of Medicine in 2006. Lindquist’s honors also include the Dickson Prize in Medicine, the Sigma Xi William Procter Prize for Scientific Achievement, and designation by Scientific American as one of the top 50 leaders in business, policy, and research for 2006. iv The Marvin J. Johnson Award in Microbial and Biochemical Technology This year’s winner of the Marvin J. Johnson Award in Microbial and Biochemical Technology is Jonathan S. Dordick, the Howard P. Isermann Professor of Chemical and Biological Engineering at the Rensselaer Polytechnic Institute (RPI). This award, which is sponsored by Pfizer, Inc., recognizes many of Professor Dordick’s achievements leading to functional bioengineered materials, enzyme-based nanocomposites, and bioactive agents that impact human health and bioprocesses. Professor Dordick will receive the award and present the award lecture titled “Molecular Bioprocessing: From Design to Discovery to Dreams" on August 21. Professor Dordick received a Ph.D. in Biochemical Engineering in 1986 from the Massachusetts Institute of Technology. He began his academic career at the University of Iowa in the Department of Chemical and Biochemical Engineering as an Assistant Professor and moved through the ranks