TOMMANDE US009877988B2UN CAURIMODUL PENTINI (12 ) United States Patent ( 10 ) Patent No. : US 9 ,877 , 988 B2 Rebar (45 ) Date of Patent: * Jan . 30 , 2018 ( 54 ) METHOD OF TREATING LYSOSOMAL 6 , 479 ,626 B1 11/ 2002 Kim et al. STORAGE DISEASES USING NUCLEASES 6 , 503 , 717 B2 1 / 2003 Case et al . 6 , 534 ,261 B1 3 / 2003 Cox , III et al. AND A TRANSGENE 6 , 599 , 692 B1 7 / 2003 Case et al. 6 , 607, 882 B1 8 / 2003 Cox et al . (71 ) Applicant: Sangamo BioSciences , Inc ., Richmond, 6 , 689 ,558 B2 2 / 2004 Case 6 , 723 , 551 B2 4 /2004 Ding et al . CA (US ) 6 , 794 , 136 B1 9 /2004 Eisenberg et al . 6 , 824 , 978 B1 11/ 2004 Cox , III et al. ( 72 ) Inventor: Edward J . Rebar, Richmond , CA (US ) 6 , 903 , 185 B2 6 / 2005 Kim et al. 6 , 933 , 113 B2 8 / 2005 Case et al . ( 73 ) Assignee : Sangamo Therapeutics, Inc. , 6 , 979, 539 B2 12/ 2005 Cox , III et al. 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