http://membership.acs.org/C/Chicago OCTOBER• 2002 CHICAGO SECTION AMERICAN CHEMICAL SOCIETY JOINT MEETING OF NORTHWESTERN UNIVERSITY DEPARTMENT OF CHEMISTRY AND THE CHICAGO SECTION ACS BASOLO MEDAL AWARD LECTURE, DINNER AND PRESENTATION FRIDAY, OCTOBER 18, 2002 , BASOLO MEDAL LECTURE These processes are being investigated LOCATION: using site-specifically platinated DNA in Northwestern University a nucleosome. A means of applying this Technological Institute information has afforded a new 2145 Sheridan Road approach to treat ovarian cancer that is Evanston, IL the basis for a clinical trial. Lecture Room 3 Metal ions are also key components of enzymes. In methanotrophic bacteria, DIRECTIONS TO THE TECH which use methane as their sole source INSTITUTE: of carbon and energy, a hydroxylase From the city: Take Lake Shore Drive enzyme (MMOH) housing a carboxy­ North to Sheridan Road into Evanston. late-bridged non-heme diiron unit acti­ Continue on Sheridan Road to the Tech vates dioxygen for the selective conver­ Institute. From the west: take 1-88 east sion of methane into methanol. This to 294 north to Dempster east. Proceed remarkable reaction proceeds in a step­ east on Dempster into Evanston. Turn wise fashion, the details of which have left onto Chicago Ave. and proceed to been delineated through structural stud­ Sheridan Road. Take Sheridan Road ies of the enzyme and its partner pro­ north to the Tech Institute. The Techno­ Prof. Stephen J. Lippard, Mas­ teins required for activity, mechanistic logical Institute is at the intersection of sachusetts Institute of Technology, studies of intermediates, and experi­ Sheridan Road and Noyes Street in Cambridge, MA. mental and theoretical analyses of the Evanston. C-H bond activation step. The transition To those attending the Basolo Medal Title: Three Avenues in Bioinorganic state involves a bound radical that lecture, parking after 4:00 p.m. is avail­ Chemistry: Cisplatin, Methane evolves products through both concert­ able in the lot across from the Techno­ Monoxygenase, and Metalloneuro­ ed insertion and recoil/rebound steps. logical Institute at the corner of Noyes chemistry Analogs of the active site have been Street and Sheridan Road. Parking is synthesized that afford insight into the also available on the side streets .j.ust Abstract: The interface between inor­ structures and chemistry of MMOH. west of this lot - however, observe the ganic and biological chemistry is broad Neurochemistry is similarly replete posted signs. Car-pooling is always and expanding. Metal ions are exten­ with inorganic ions essential for func­ encouraged. sively applied in diagnostic and thera­ tion. New fluorescent sensors for zinc Lecture room 3 is on the first floor of peutic medicine. The simple coordina­ and nitric oxide have been obtained the Technological Institute and is most tion compound cis-d iamminedichloro­ that have the potentia l to map neura l easily reached by entering through the platinum(I I), also known as cisplatin, networks in the hippocampus, the cen­ main doors facing Sheridan Road. The has contributed significantly to the man­ ter of learning and memory. lecture room is clearly marked and agement of testicular cancer. This and there will be signs at the entrance to related platinum anticancer drugs kill NOTICE TO ILLINOIS guide you to the room. cancer cells through a multifactorial mechanism. The first step is activation TEACHERS Basolo Medal to facilitate DNA binding. Structures of The Chicago Section-ACS is an Lecture: 4:30 - 5:45 P.M. the major platinum-DNA adduct reveal ISBE provider for professional devel­ The Medalist Lecture is open to the distortions of the double helix that trig­ opment units for Illinois Teachers . public and admission is free to all those ger the interaction of proteins involved Teachers who register for the October wishing to attend. in gene activation. Inhibition of the key meeting will have the opportunity to cellular processes of transcription and earn up to 5 CPDU's. nucleotide exc ision repair ensues. (continued on page 2) 10/02 2 (continued from page 1) DINNER LOCATION: should be received in the Section Office Kendall College Culinary School via phone (847-647-8405), fax (847- Biography: Professor Lippard was 2408 Orrington Avenue 647 -8364) , webs ite (http ://member ­ born in Pittsburgh, PA, was an under­ Evanston, IL ship.acs.o rg/C/Chicago ), or email to graduate at Haverford College (B.A., The Dining Room chicagoacs@ameritech .net. Because 1962) and completed his graduate work 84 7 -866-1300 of the special nature of this program at M.I.T., receiving the Ph.D. in 1965. and its location, we are asking that you After a postdoctoral year as an NSF DIRECTIONS TO KENDALL COLLEGE: make your reservations ear lier than Fellow at M.I.T., he joined the faculty of Kendall College is located just a short usual and, if possible, by Wednesday , Columbia Unive rsity as an Ass istant walk (about 3 blocks) from the Tech October 9, 2002. Professor in 1966 , was appointed to Institute . If you are not attending the The dinner cost is $35.00. The cost to Associate Professor with tenure in 1969 lecture and, instead, driving directly to students and unemployed members is and to fu ll Professor in 1972. He Kendall College Culinary Schoo l, the $17 .50. PLEASE HONOR YOUR returned to M.I.T. as Professor of following are directions from the Edens RESERVATIONS. The Section must Chem istry in 1983 , was appointed Expressway . Take the Edens to the pay for all dinner orders. No-shows will Arthur Amos Noyes Professor in 1989, Old Orchard Road ex it. Proceed be billed. and Head of the Chemistry Department straight east to Green Bay Road and This is the third year we have had the in 1995. turn north two blocks to Central Street. Basolo Medal dinner and presentation Professor Lippard has received many Turn right onto Central Street and go at Kendall College. All those attending fellowships and prizes , including the two streets beyond Ridge Road to can look forward to a wonderful evening Henry J. Albert Award of the Interna­ Orr ington Avenue. Turn south onto and a truly fine dining experience. tional Precious Metals Institute for his Orrington Avenue 1.5 blocks. The culi­ work on platinum metals and their inter­ nary school has limited parking in the General Meeting: 8:00 P.M. actions with nucleic acids , election as lot adjacent to the dining room. Parking Presentation of the Basolo Medal and Fellow of the American Academy of is also available on the neighborhood remarks: Susan Shih, Chair , Chicago Arts and Sciences, the ACS Award in side streets. Observe the posted signs. Section American Chemical Society ; Inorganic Chemistry sponsored by Michael R. Wasielewski , Chairman , Monsanto Company , the Remsen Reception: 6:00 - 7:00 P.M. Chemistry Dept., Northwestern Univer­ Award sponsored by the Maryland Sec­ Complementary wine , soft drinks , and sity ; Prof. Stephen J. Lippard , 2002 tion of the ACS , an Alexander von hors d'oeuvres served butler style. Hors Basolo Medalist, MIT, Cambridge, MA. Humboldt Senior U.S. Scientist Award, d'oeuvres selection: Salmon Canapes election to the National Academy of (Scottish salmon with chive spread and REGISTERTO ATTEND Sciences, election to the National Insti­ caviar) , Shrimp Fritters (Battered rock MONTHLYSECTION MEETINGS tute of Medicine, the John C. Bailar, Jr. shrimp with fresh ginger, corn, soy and Metal of the University of Illinois , the cilantro and chutney), Lamb Tenderloin ONLINE ACS Award for Distinguished Service in with mint yogurt and couscous, Spinach Inorgan ic Chemistry sponsored by and Feta Cheese wrapped in a at Mallinckrodt Company, the William H. phyllo purse. http://membership.acs.org/C/Chicago Nichols Metal sponsored by the New York Section of the ACS, an Honorary Dinner: 7:00 P.M. IN THIS ISSUE D.Sc. Degree from Texas A&M Univer­ Kendall College is the site of the pre­ jeatures sity , an honorary membership in the mier cul inary school in the Midwest , Italian Chemical Society , scientific training chefs to work in the finest and 1 .... Basolo Medal Lecture membership in the Max-Planck­ most expens ive restaurants. The first 3 . ... Chair's Letter Gesellschaft, an honorary D.Sc. degree course will be Pumpkin Soup (roasted 4 . .. Senatorial Q&A from Haverford College , and the pumpkin with allspice served with vanil­ 5 .... Book Review Richards Metal of the Northeast Section la bean cream). The second course will 6 .... High School Chemistry Teacher of the ACS . be a pear and walnut salad (poached Award He is author or co-author of over 550 pears and toasted walnuts served with 7 .... Student Affiliates Drive & art icles in professional and scholarly mesclun greens, port wine vinaigrette, Contest journals , has written or edited two text­ and blue cheese). The main course is a 7 .... Continuing Education Seminars books, and holds several U.S. and for­ choice of Lavender Chicken (Lavender 7 . ... The Basolo Medal eign patents. He has published a book honey-glazed ch icken served with 8 . .. New Section Members with Jeremy Berg entitled "Principles of creamy goat cheese po lenta and 9 .... YCC Happy Hour Bioinorganic Chemistry." caramelized red onions and escarole), 10 ... Section's Project SEED Dr. Lippard's research activities span Scaloppin i of Grouper (Almond herb Program the fields of inorganic and biological crusted grouper pan fried and served 11 ... K-8 Teachers Program chemistry . Included are structural and with mushroom risotto and tomato 11 ... Chemistry Day 2002 mechanistic studies of plat inum anti­ coulis) , or Vegetarian free-form Pasta 11 .. Continuing Education cancer drugs and of methane monooxy­ (Egg pasta layered with eggplant , Committee genase, the synthesis of carboxylate­ portabella mushrooms , saute spinach, In 'Every Issue bridged dimetallic complexes as models sun-dried tomatoes and ricotta cheese for redox-active enzymes and metallo­ and tomato basil sauce; an assortment 2 ...