Webtable 2. Acute lymphoblastic leukaemia Treatment Phenotype Age n Pregnancy complications Web ref* Trimester 1 Vincristine, dactinomycin, idarubicin Normal 2 years 2 .. 6 Doxorubicin, vincristine No anomalies .. 1 Spontaneous abortion at 17 weeks 6 Doxorubicin, vincristine, mercaptopurine, Normal 4 years 1 .. 22 methotrexate, prednisone, etoposide Mercaptopurine, triamcinolone Normal 22 years 2 .. 22 Vincristine, cytarabine, prednisone Normal 7 years 3 .. 22 Cyclophosphamide, mercaptopurine, Normal .. 1 IUGR, pancytopenia, died, sepsis at 22 methotrexate, cytarabine, prednisone 3 weeks Doxorubicin, vincristine, mercaptopurine, Normal 5–8 years 5 .. 22 methotrexate, prednisone Doxorubicin, vincristine, cyclophosphamide, Normal 19 years 4 Transient pancytopenia in one case 22,23 mercaptopurine, methotrexate, prednisone Cyclophosphamide, mercaptopurine, Normal .. 1 .. 23 methotrexate Vincristine, tioguanine, cytarabine, Normal fetal autopsy .. 1 Maternal death at 20 weeks, 24 prednisone, daunorubicin pseudomonas, bronchopneumonia Mercaptopurine Normal .. 1 .. 25 Cytarabine Microtia, right-hand abnormality, .. 1 .. 26 bilateral leg deformities Cytarabine Normal .. 2 .. 27 Vincristine, tioguanine, cytarabine Normal .. 2 IUGR 27 Cyclophosphamide, prednisone Female twin normal; .. 1 Female twin healthy; neuroblastoma 28 male twin: oesophageal atresia, at 14 years. Male twin: IUGR, anaemia, abnormal IVC, right arm deformity papillary thyroid cancer at 11 years Vincristine, cyclophosphamide, Normal .. 3 .. 29 cytarabine, asparaginase, prednisone, daunorubicin Vincristine, prednisone Normal 4 years 2 .. 30 Vincristine, cyclophosphamide, Normal 3 months 1 .. 31 mercaptopurine, methotrexate, asparaginase, prednisone, daunorubicin Vincristine, mercaptopurine, methotrexate, Normal 8 years 4 Pre-eclampsia, HELLP in one case 31,32 prednisone Trimester 2 Vincristine, mercaptopurine, methotrexate, Normal, normal T-cell function 54 months 1 .. 4 asparaginase, prednisone, daunorubicin Vincristine, prednisone, epirubicin No anomalies .. 1 IUFD at 30 weeks 6 Doxorubicin, cytarabine Normal 4–6 years 2 22 Doxorubicin, vincristine, cyclophosphamide, Normal 8–11 years 1 .. 23 mercaptopurine, methotrexate, prednisone Doxorubicin, vincristine, cyclophosphamide Normal 29 months 1 .. 33 Doxorubicin, vincristine, mercaptopurine, Normal .. 1 .. 34 methotrexate, prednisone Mercaptopurine, triamcinolone Normal .. 1 .. 34 Vincristine, mercaptopurine, methotrexate, Normal .. 1 IUGR, died at 90 days, gastroenteritis 35 cytarabine, prednisone Doxorubicin, vincristine, asparaginase, Normal 30 months 1 Premature rupture of membranes at 36 prednisone, intrathecal methotrexate, 34 weeks radiation to head Vincristine, cyclophosphamide, Normal 1 year 1 Myelosuppression 37 mercaptopurine, asparaginase, prednisone, daunorubicin Doxorubicin, vincristine, cyclophosphamide, Normal .. 1 Leucopenia 38 mercaptopurine, methotrexate, asparaginase, prednisone Continued... THE LANCET Oncology Vol 5 May 2004 http://image.thelancet.com/extras/03oncl0502webtable2.pdf For personal use. Only reproduce with permission from The Lancet. Continued... Treatment Phenotype Age n Pregnancy complications Web ref* Vincristine, cyclophosphamide, Normal, ring chromosome, several .. 1 .. 39 mercaptopurine, methotrexate, cytarabine, chromosome gaps asparaginase, prednisone, daunorubicin Vincristine, cyclophosphamide, Transient cardiomyopathy, normal 18 months 1 .. 40 daunorubicin, idarubicin neurological development, delayed language, normal heart function by day 3 of life Trimester 3 Doxorubicin, vincristine, prednisone Normal 40 months 4 .. 22,23 to 17 years Vincristine, cyclophosphamide, Normal 7 months 1 .. 41 mercaptopurine, methotrexate, cytarabine, prednisone Vincristine, prednisone, daunorubicin Normal .. 1 .. 42 Vincristine, cyclophosphamide, Normal .. 1 Transient oligohydramnios, meconium, 43 mercaptopurine, methotrexate, 10% birthweight asparaginase, prednisone, daunorubicin Doxorubicin, vincristine, methotrexate, Normal 6 months 1 Polycythaemia 44 cytarabine, prednisone IUGR, intrauterine growth restriction; IVC, inferior vena cava; HELLP, haemolysis, elevated liver enzymes, and low platelet count; IUFD, intrauterine fetal death. *These references are available only on the web, see http://image.thelancet.com/extras/03oncl0502webfr.pdf. THE LANCET Oncology Vol 5 May 2004 http://image.thelancet.com/extras/03oncl0502webtable2.pdf For personal use. Only reproduce with permission from The Lancet..