2015 RESEARCH DAY Program and Abstracts Wednesday, November 18, 2015 7:30 a.m. – 5:05 p.m. St. Elias Centre 750 Ridgewood Ave. Ottawa, ON Research Day is generously supported by: DRS Construction Research Day Committee The Ottawa Hospital Research Institute would like to express its appreciation to members of the Research Day Committee for their dedication and hard work in organizing this event, and to the volunteers, whose assistance we could not do without. Dr. Fraser Scott (Chair) Dr. Jay Baltz Jane Canniff Dr. Ketul Chaudhary Dr. Angela Crawley Dr. Jim Dimitroulakos Dr. Dean Fergusson Dr. Anouk Fortin Jennifer Ganton Dr. Jelena Ivanovic Dr. Ian Lorimer Dr. Tim Ramsay Dr. Luc Sabourin Dr. William Stanford Dr. Duncan Stewart Dr. Catherine Tsilfidis Volunteers Greg Canham Melanie Genereaux Wayne Lowe 2015 Research Day WELCOME TO RESEARCH DAY Today, we celebrate and showcase the outstanding work of our young researchers. Their insight, passion and commitment to scientific excellence are critical to our success as one of Canada’s top research hospitals, ranking 3rd overall in terms of funding from the Canadian Institutes of Health Research. This day is meant to foster and encourage interaction in a collegial environment for our trainees – to give them experience communicating their ideas clearly and effectively. Even if you are not involved in the judging of posters or oral presentations, I hope you will ask questions of our trainees. As well as providing this learning opportunity, today is a great chance for us all to learn about the exciting research projects taking Duncan Stewart, MD, FRCPC place across The Ottawa Hospital. Executive Vice-President, Research, The Ottawa Hospital We are an organization with a broad scope of research endeavours, CEO & Scientific Director, Senior ranging from the lab to the clinic to the community. To reflect this, today Scientist in the Regenerative we are presenting two keynote lectures. Medicine Program, Ottawa Hospital Research Institute The first will be given by Dr. Peter Zandstra, a world-renowned pioneer in Evelyne and Rowell Laishley Chair stem cell bioengineering. Dr. Zandstra’s research has generated important Professor, Department of Medicine, insights into the fundamental mechanisms that control stem cell fate, and Faculty of Medicine, University of Ottawa led to the development of robust technologies for the use of stem cells and their derivatives to treat disease. The title of his talk today is "Patterning mesoderm and blood development from human pluripotent stem cells“. The second lecture will be given by Dr. Harvey Max Chochinov. Dr. Chochinov is one of the world’s leading experts in palliative care - defining best practices for helping people near the end of life. His talk, titled “Dignity, Personhood & the Culture of Medicine” is incredibly timely given the Supreme Court’s recent ruling that Canadians have a right to physician-assisted suicide. I would also like to draw your attention to the 5th Annual IMPACT Award. Standing for “Identification of Marketable Products, Applications and Commercializable Technologies,” the IMPACT Award is designed to encourage our researchers to consider how their work could lead to innovations and to identify technologies, products or services that stem from their work. The IMPACT Award is part of our larger effort to create a culture that is proactive in translating research into benefits for Canadians. You will find the finalists' posters in the lobby. On behalf of everyone at the Ottawa Hospital Research Institute, I would like to thank all those involved in making this day happen, from our guest speakers to our presenters, judges, planning committee and volunteers. I would also like to thank the sponsors for helping to make today’s event possible and encourage you to visit their tables. 1 2015 Research Day DR. J. DAVID GRIMES LECTURE Dr. J. David Grimes, MD, FRSPC This annual lecture is named in honour of Dr. J. David Grimes, founder of the Loeb Research Institute, which was the predecessor of the Ottawa Hospital Research Institute at the Civic Campus. Dr. Grimes served as the Institute’s CEO and Scientific Director until he retired in 1997. He recruited and mentored many of Ottawa’s leading health researchers. He also practiced neurology for more than 25 years, specializing in Parkinson’s disease. After a long and courageous battle with lung disease, Dr. Grimes passed away on May 9, 2001. A man of great vision and compassion, Dr. Grimes is missed by everyone who knew him. This annual lecture is just one of the ways his memory lives on at the Ottawa Hospital Research Institute. He is also remembered through the Dr. J. David Grimes Research Chair at the University of Ottawa and through the Grimes Career Achievement Award, which is awarded annually at The Ottawa Hospital Gala. 2 2015 Research Day DR. J. DAVID GRIMES LECTURE “Patterning mesoderm and blood development from human pluripotent stem cells” Dr. Peter Zandstra Dr. Peter Zandstra is a Professor at the University of Toronto and holds the Canada Research Chair in Stem Cell Bioengineering. He is also the Chief Scientific Officer of the Centre for the Commercialization of Regenerative Medicine and Co-Director (with Dr. Janet Rossant) of the Ontario Institute of Regenerative Medicine. Research in Dr. Zandstra’s laboratory is focused on the generation of functional tissue from adult and pluripotent stem cells. His group’s quantitative, bioengineering-based approach strives to gain new insight into the fundamental mechanisms that control stem cell fate and to develop robust technologies for the use of stem cells and their derivatives to treat disease. KEYNOTE LECTURE “Dignity, Personhood & the Culture of Medicine” Dr. Harvey Max Chochinov Dr. Harvey Max Chochinov is a Distinguished Professor of Psychiatry at the University of Manitoba and Director of the Manitoba Palliative Care Research Unit, CancerCare Manitoba. His seminal publications addressing psychosocial dimensions of palliation have helped define core-competencies and standards of end-of-life care. He holds the Canada Research Chair in Palliative Care, is an Officer of the Order of Canada and is a recipient of the Order of Manitoba. He is the Chair for the Canadian Virtual Hospice, a Fellow of the Royal Society of Canada and a Fellow of the Canadian Academy of Health Sciences. His most recent book, Dignity Therapy: Final Words for Final Days, is published by Oxford University Press and was the 2012 winner of the American Publisher’s Association Prose Award for Clinical Medicine. 3 2015 Research Day DR. GOODMAN COHEN SUMMER STUDENT AWARDS Every year, the Ottawa Hospital Research Institute holds the summer student seminar series, which gives students the opportunity to present their research to other students. This year, more than 50 students participated from throughout the Institute, ranging from high-school students to newly graduated Bachelor’s students. Awards are given for the best presentations, based on both peer and coordinator evaluations. The students then submit a written paper and the top students are awarded the Dr. Goodman Cohen Summer Student Award. This year they competed in two categories: Senior (returning students) and Junior (new students). Dr. Jay Baltz, Associate Scientific Director responsible for Trainees, would like to thank Drs. Jennifer Collins and Mehdi Shafa for their excellent job running the summer student program this year. Winners of the Dr. Goodman Cohen Summer Student Award Senior Award Olivia Cook (supervised by Venkatesh Thiruganasambandamoorthy) "Reasons for Referrals and Hospital Admissions among Emergency Department Syncope Patients" Junior Award Lubina Nayak (supervised by Rodney Breau) "Continence and Complications in Patients with Neobladder Diversions" Dr. Goodman Cohen The Dr. Goodman Cohen Summer Student Awards are made possible by generous donations made in the memory of Dr. Goodman (Goody) Cohen, one of Ottawa's first and finest cardiologists. Born in 1922, Dr. Cohen grew up in a tiny rural mining town located between Glace Bay and Sidney in Nova Scotia. The youngest of seven siblings (five boys and two girls), Dr. Cohen was the only one in this family to attend university, starting his post-secondary education at Mount Allison University in Sackville, New Brunswick. He went on to graduate from McGill Medical School in the early 1950s before doing post-graduate work at Harvard and Johns Hopkins universities. He met his future wife, Rita Lambert, a nurse, while training at Massachusetts General Hospital. They settled in Ottawa where they raised three children. Dr. Cohen, known as Goody, practiced cardiology for almost 35 years, until 1989 when he was diagnosed with cancer. He died in January 1990. Widely known as a kind and caring physician to thousands of patients over the years, he was also highly respected as a clear and forthright professor of medicine. 4 2015 Research Day RESEARCH TRAINEE SALARY AWARDS See more of our trainees’ photos on the inside back cover Amelia Aitken Nicole Forbes John Saber Almohanad Alkayyal Alexander Gont Bratati Saha Khalid Al-Zahrani Daniel Guindon Teslin Sandstrom Leonard Angka Tavis Hayes Aimee Sarti Marc Thomas Avey Mirabelle Ho Mohammed Selman Andrew Aw Amy Hsu Mehdi Shafa Justine Baron Hua Huang Melissa Snyder Katherine Baxter Danton Ivanochko Roger Stanev Laura Boland Lisa Marie Julian Colin Suen Marie-Claude Bourgeois-Daigneault Brian Keller Maxwell Sunohara Caroline Brun Faizan Khan Mohamad Taha Adriana Carbonel Sarwat Khan Lee-Hwa Tai Natasha