MAIMOTOMONTANT US009944986B2 DIU TO DI UN ANONLINE (12 ) United States Patent (10 ) Patent No. : US 9 , 944 , 986 B2 Nagy (45 ) Date of Patent: Apr . 17 , 2018 ( 54 ) THERAPEUTIC TARGETS FOR Hirschhorn et al. (Genetics in Medicine. vol. 4 , No. 2 , pp . 45- 61 , ALZHEIMER ' S DISEASE Mar . 2002 ) . * Lucentini et al ( The Scientist ( 2004 ) vol. 18 , p . 20 ) . * ( 71 ) Applicant : The University of Birmingham , Langdahl ( Journal of Bone and Mineral Research 2000 vol . 15 , No. 3 , pp . 402 -414 ) .* Birmingham (GB ) Wall (Nature Reviews Genetics ( 2003) vol. 4 , pp . 587 -597 ) . * (72 ) Inventor : Zsuzsanna Nagy , Birmingham (GB ) Abramsson et al. , “ No Association of LOXLI Gene ( 73 ) Assignee : The University of Birmingham , Polymprophisms with Alzheimer ' s Disease ” , Neuromol. Med . , 13 : 160 - 166 ( 2011 ) . 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See application file for complete search history . Liu et al. , “ A Genomewide Screen for Late -Onset Alzheimer Disease in a Genetically Isolated Dutch Population ” , The American ( 56 ) References Cited Journal of Human Genetics , 81: 17 -31 ( 2007) . U . S . PATENT DOCUMENTS (Continued ) Primary Examiner — Katherine D Salmon 2002/ 0015941 Al * 2 / 2002 Kim . .. .. .. .. GOIN 33 /5008 (74 ) Attorney , Agent, or Firm — Kathleen D . Rigaut; 435 / 4 2003 /0092019 A1 * 5 / 2003 Meyer . .. .. .. .. .. .. .. CO7K 14 / 47 Dann , Dorfman , Herrell and Skillman , P . C . 435 / 6 . 14 (57 ) ABSTRACT The present invention relates to novel methods for the FOREIGN PATENT DOCUMENTS prevention , treatment and diagnosis of Alzheimer ' s disease . In addition , the invention relates to methods for assessing an WO 2011/ 012672 A1 2 /2011 individual' s susceptibility or pre - disposition to Alzheimer ' s disease . The methods of the present invention involve the use of therapeutic targets and diagnostic and /or predictive OTHER PUBLICATIONS markers within the mTOR signalling pathway . The methods Morita ( AJH 2006 vol. 19 pp . 593 -600 ) . * also involve screening subjects for genetic polymorphisms Bertram ( The American Journal of Human Genetics Nov . 7 , 2008 associated with rapamycin - sensitive genes . vol. 83 pp . 623 -632 ). * 4 Claims, 34 Drawing Sheets US 9 ,944 , 986 B2 Page 2 References Cited Ueberham et al. , “ Altered subcellular location of phosphorylated ( 56 ) SMads in Alzheimer' s disease” , European Journal of Neuroscience , 24 : 2327 - 2334 (2006 ) . 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