Get to the heart of pain relief Explain why analgesic choice matters to patients with, or at risk for, cardiovascular disease Counseling tips | Dosage | Savings Analgesic considerations that matter to the heart Reinforce your TYLENOL® recommendation to patients with, or at risk for, cardiovascular disease with these counseling tips: TYLENOL® won’t increase the risk of heart attack, heart failure, or stroke the way ibuprofen or naproxen sodium can1 TYLENOL® won’t interfere with aspirin heart therapy the way ibuprofen can2 TYLENOL® won’t increase blood pressure like NSAIDs sometimes can3,4 TYLENOL® won’t interfere with certain high blood pressure medications, such as diuretics and ACE inhibitors, the way NSAIDs sometimes can3,4 Order patient education, samples, and coupons at TylenolProfessional.com Not a member? Register today! The efficacy and safety of TYLENOL® at 4000 mg/day are well established. Healthcare professionals may exercise their discretion and recommend up to 4000 mg. Dosage for Adults Recommended dose from your healthcare professional: mg/day TYLENOL® Regular Strength Active ingredient: acetaminophen 325 mg (per tablet) Use only as directed. DOSE & FREQUENCY DAILY LIMIT 2 tablets every 4 to 6 hours Do not take more than 10 tablets while symptoms last in 24 hours, unless directed by your doctor TYLENOL® Extra Strength Active ingredient: acetaminophen 500 mg (per caplet) Use only as directed. DOSE & FREQUENCY DAILY LIMIT 2 caplets every 6 hours while Do not take more than 6 caplets symptoms last in 24 hours, unless directed by your doctor TYLENOL® 8 HR Arthritis Pain Active ingredient: acetaminophen 650 mg (per extended-release caplet) Use only as directed. DOSE & FREQUENCY DAILY LIMIT 2 bi-layer caplets every Do not take more than 6 bi-layer caplets 8 hours with water in 24 hours TYLENOL® is the #1 doctor recommended brand of pain reliever for those with high blood pressure. See heart health pain reliever tips MANUFACTURER COUPON | EXPIRES 12/31/2020 SAVE $1.00 On any one (1) TYLENOL® Regular Strength, TYLENOL® Extra Strength, or TYLENOL® 8 HR Arthritis Pain product. Use products only as directed. Excludes trial sizes. See back for details. TYLENOL® works differently than other pain relievers TYLENOL® (acetaminophen) works differently than MOTRIN® IB and Advil® (ibuprofen), Aleve® (naproxen sodium), and aspirin, which are all NSAIDs.* TYLENOL® won’t increase your risk of TYLENOL® won’t increase your blood heart attack, heart failure, or stroke the pressure like NSAIDs sometimes can way ibuprofen or naproxen sodium can TYLENOL® won’t interfere with certain TYLENOL® doesn’t interfere with aspirin high blood pressure medications the heart therapy the way ibuprofen can way NSAIDs sometimes can Check your medicines Always read and follow the label, and take only one medicine that contains the same kind of active ingredient at a time. This may help reduce your risk of harmful side effects. Medicine brands with products that contain acetaminophen Over-the-counter (OTC) Prescription Alka-Seltzer Plus® NyQuil® Endocet® Roxicet™ DayQuil® Pamprin® Fioricet® Ultracet® Excedrin® Robitussin® Lortab® Vicodin® Goody’s® SUDAFED® Norco® TYLENOL® with Codeine Mucinex® TYLENOL® Percocet® Medicine brands with products that contain an NSAID Over-the-counter (OTC) Prescription Advil® Excedrin® Celebrex® Naproxen Aleve® Goody’s® Ibuprofen Relafen® Alka-Seltzer Plus® Midol® Inocin® Toradol® Anacin® MOTRIN® Lodine® Vicoprofen® Bayer® Sudafed® Mobic® Voltaren® This is not a complete list of brands with products that contain acetaminophen or an NSAID. * NSAID stands for nonsteroidal anti-inflammatory drug. The third party trademarks used herein are trademarks of their respective owners. © Johnson & Johnson Consumer Inc. 2019 EST-567328 MANUFACTURER COUPON | EXPIRES 12/31/2020 CONSUMER: This coupon good only on purchase of product indicated. Any other use constitutes fraud. COUPON CANNOT BE BOUGHT, TRANSFERRED OR SOLD. LIMIT ONE COUPON PER PURCHASE AND ONE COUPON PER CUSTOMER. VOID IF TAXED, RESTRICTED OR PROHIBITED BY LAW. VOID IF COPIED OR EXPIRED. RETAILER: Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division SAVE $1.00 will reimburse you for the face value of this coupon plus 8¢ if submitted in compliance with Johnson & Johnson Consumer Inc., McNeil Consumer On any one (1) TYLENOL® Regular Healthcare Division Coupon Redemption Strength, TYLENOL® Extra Policy and incorporated herein by reference. Cash value 1/20th of one cent. Strength, or TYLENOL® 8 HR Send coupons to: Johnson & Johnson Consumer Inc., McNeil Consumer Arthritis Pain product. Healthcare Division 1453, NCH, P.O. Box 880001, El Paso, TX 88588-0001. Excludes trial sizes. © J&JCI 2019 EST-567328 Order patient education, samples, and coupons at TylenolProfessional.com Not a member? Register today! Acetaminophen and NSAIDs are found in hundreds of medicines Your patients may not know. Remind them to always read and follow the label, and take only one medicine that contains the same kind of active ingredient at a time. This may help reduce the risk of harmful side effects. Common medicines that contain acetaminophen OTC Prescription Alka-Seltzer Plus®* Mucinex® Endocet® Tylox® BENADRYL® NyQuil® Fioricet® Ultracet® Comtrex® DayQuil® Lorcet® Vicodin® Contac® Pamprin® Lortab® Coricidin® Robitussin® Maxidone® Dimetapp® SUDAFED®† Norco® Dristan®* Tavist® Percocet® Excedrin®* Theraflu® Roxicet™ FeverAll® TYLENOL® TYLENOL® with Codeine Goody’s®* Vanquish® Midol®* Vicks® Common medicines that contain an NSAID OTC Prescription Advil® Ecotrin® Celebrex® Mobic® Aleve® Excedrin®* Clinoril® Naproxen Alka-Seltzer Plus®* Goody’s®* Daypro® Relafen® Anacin® Midol®* Dolobid® Toradol® Bayer® MOTRIN® Feldene® Ultracet® BC®* Ibuprofen Vicoprofen® Bufferin® Inocin® Voltaren® Dristan®* Lodine® This is not a complete list. *Many OTC brands (like Midol® and Alka-Seltzer Plus®) have different formulations that contain acetaminophen or an NSAID. †Not all SUDAFED® formulations contain acetaminophen. REFERENCES: 1. US Food and Drug Administration. FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm453610.htm. Accessed January 12, 2018. 2. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 3. Elliott WJ. Drug interactions and drugs that affect blood pressure.J Clin Hypertens. 2006;8(10):731-737. 4. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107:628-635. The third party trademarks used herein are trademarks of their respective owners. © Johnson & Johnson Consumer Inc. 2019 EST-567328.