Recombinant PRDM1 Protein

Recombinant PRDM1 Protein

Recombinant PRDM1 protein Catalog No: 81277, 81977 Quantity: 20, 1000 µg Expressed In: Baculovirus Concentration: 0.4 µg/µl Source: Human Buffer Contents: Recombinant PRDM1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, 0.5 mM TCEP. Background: PRDM1 (PR/SET Domain 1), also called as Beta-Interferon Gene Positive-Regulatory Domain I Binding Factor, or BLIMP1, is a transcription factor that acts as a repressor of beta-interferon gene expression. It mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. PRDM1 plays a role in the development, retention and long-term establishment of adaptive and innate tissue- resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Protein Details: Recombinant PRDM1 was expressed in a baculovirus expression system as the full length protein (accession number NP_001189.2) with an N-terminal FLAG tag. The molecular weight of PRDM1 is 93 kDa. Application Notes: This product was manufactured as described in Protein Details. Recombinant PRDM1 protein gel Where possible, Active Motif has developed functional or activity assays for 9% SDS-PAGE gel with Coomassie recombinant proteins. Additional characterization such as enzyme kinetic activity blue staining assays, inhibitor screening or other biological activity assays may not have been MW: 93 kDa performed for every product. All available data for this product is shown. Purity: >85% Storage and Guarantee: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival. North America 877 222 9543 • Europe +32 (0)2 653 0001 • Japan +81 (0)3 5225 3638 • www.activemotif.com.

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