KO_id Functional hierarchy 1 Functional hierarchy 2 Module_id Module description Name Definition Life_style K00611 Amino acid metabolism Arginine and proline metabolism M00029 Urea cycle [PATH:map00220 map01230 map01100] OTC, argF, argI ornithine carbamoyltransferase [EC:2.1.3.3] FL-ls K00611 Amino acid metabolism Arginine and proline metabolism M00844 Arginine biosynthesis, ornithine => arginine [PATH:map00220OTC, map01230argF, argI map01100]ornithine carbamoyltransferase [EC:2.1.3.3] FL-ls K00286 Amino acid metabolism Arginine and proline metabolism M00015 Proline biosynthesis, glutamate => proline [PATH:map00330proC map01230 map01100]pyrroline-5-carboxylate reductase [EC:1.5.1.2] PA-ls K00818 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220E2.6.1.11, map01210 argD map01230acetylornithine map01100] aminotransferase [EC:2.6.1.11] PA-ls K00619 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argA map01210 map01230amino-acid map01100] N-acetyltransferase [EC:2.3.1.1] PA-ls K00620 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argJ map01210 map01230glutamate map01100] N-acetyltransferase / amino-acid N-acetyltransferasePA-ls [EC:2.3.1.35 2.3.1.1] K00930 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argB map01210 map01230acetylglutamate map01100] kinase [EC:2.7.2.8] shared K01438 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argE map01210 map01230acetylornithine map01100] deacetylase [EC:3.5.1.16] shared K14682 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argAB map01210 map01230amino-acid map01100] N-acetyltransferase [EC:2.3.1.1] shared K00145 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220argC map01210 map01230N-acetyl-gamma-glutamyl-phosphate map01100] reductase [EC:1.2.1.38]shared K12659 Amino acid metabolism Arginine and proline metabolism M00028 Ornithine biosynthesis, glutamate => ornithine [PATH:map00220ARG56 map01210 map01230N-acetyl-gamma-glutamyl-phosphate map01100] reductase / acetylglutamateshared kinase [EC:1.2.1.38 2.7.2.8] K01438 Amino acid metabolism Arginine and proline metabolism M00845 Arginine biosynthesis, glutamate => acetylcitrulline => arginineargE [PATH:map00220acetylornithine map01230 map01100]deacetylase [EC:3.5.1.16] shared K00145 Amino acid metabolism Arginine and proline metabolism M00845 Arginine biosynthesis, glutamate => acetylcitrulline => arginineargC [PATH:map00220N-acetyl-gamma-glutamyl-phosphate map01230 map01100] reductase [EC:1.2.1.38]shared K09065 Amino acid metabolism Arginine and proline metabolism M00845 Arginine biosynthesis, glutamate => acetylcitrulline => arginineargF [PATH:map00220N-acetylornithine map01230 map01100] carbamoyltransferase [EC:2.1.3.9] shared K03785 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoD => chorismate [PATH:map004003-dehydroquinate map01230 dehydratase map01100 I [EC:4.2.1.10] map01110 map01130]FL-ls K00800 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoA => chorismate [PATH:map004003-phosphoshikimate map01230 1-carboxyvinyltransferase map01100 map01110 map01130] [EC:2.5.1.19]FL-ls K01736 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoC => chorismate [PATH:map00400chorismate synthase map01230 [EC:4.2.3.5] map01100 map01110 map01130]FL-ls K00014 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoE => chorismate [PATH:map00400shikimate dehydrogenase map01230 map01100 [EC:1.1.1.25] map01110 map01130]FL-ls K00891 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4PE2.7.1.71, => chorismate aroK, [PATH:map00400 aroLshikimate kinase map01230 [EC:2.7.1.71] map01100 map01110 map01130]FL-ls K00766 Amino acid metabolism Aromatic amino acid metabolism M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:map00400trpD map01230anthranilate map01100 phosphoribosyltransferase map01110] [EC:2.4.2.18] FL-ls K13503 Amino acid metabolism Aromatic amino acid metabolism M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:map00400trpEG map01230anthranilate map01100 synthase map01110] [EC:4.1.3.27] FL-ls K01609 Amino acid metabolism Aromatic amino acid metabolism M00023 Tryptophan biosynthesis, chorismate => tryptophan [PATH:map00400trpC map01230indole-3-glycerol map01100 map01110] phosphate synthase [EC:4.1.1.48] FL-ls K04518 Amino acid metabolism Aromatic amino acid metabolism M00024 Phenylalanine biosynthesis, chorismate => phenylalaninepheA2 [PATH:map00400 map01230prephenate map01100 dehydratase map01110] [EC:4.2.1.51] FL-ls K00452 Amino acid metabolism Aromatic amino acid metabolism M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconateHAAO [PATH:map003803-hydroxyanthranilate map01100] 3,4-dioxygenase [EC:1.13.11.6] FL-ls K03392 Amino acid metabolism Aromatic amino acid metabolism M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconateACMSD [PATH:map00380aminocarboxymuconate-semialdehyde map01100] decarboxylase [EC:4.1.1.45]FL-ls K01556 Amino acid metabolism Aromatic amino acid metabolism M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconateKYNU, kynU [PATH:map00380kynureninase map01100] [EC:3.7.1.3] FL-ls K00486 Amino acid metabolism Aromatic amino acid metabolism M00038 Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconateKMO [PATH:map00380kynurenine 3-monooxygenase map01100] [EC:1.14.13.9] FL-ls K05710 Amino acid metabolism Aromatic amino acid metabolism M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoAhcaC [PATH:map003603-phenylpropionate/trans-cinnamate map01220 map01120] dioxygenase ferredoxinFL-ls component K05708 Amino acid metabolism Aromatic amino acid metabolism M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoAhcaE, [PATH:map00360 hcaA1 3-phenylpropionate/trans-cinnamate map01220 map01120] dioxygenase subunitFL-ls alpha [EC:1.14.12.19] K05709 Amino acid metabolism Aromatic amino acid metabolism M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoAhcaF, [PATH:map00360 hcaA2 3-phenylpropionate/trans-cinnamate map01220 map01120] dioxygenase subunitFL-ls beta [EC:1.14.12.19] K01735 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoB => chorismate [PATH:map004003-dehydroquinate map01230 synthase map01100 [EC:4.2.3.4] map01110 map01130]PA-ls K01850 Amino acid metabolism Aromatic amino acid metabolism M00024 Phenylalanine biosynthesis, chorismate => phenylalanineE5.4.99.5 [PATH:map00400 map01230chorismate map01100 mutase [EC:5.4.99.5] map01110] PA-ls K04092 Amino acid metabolism Aromatic amino acid metabolism M00024 Phenylalanine biosynthesis, chorismate => phenylalaninetyrA1 [PATH:map00400 map01230chorismate map01100 mutase [EC:5.4.99.5] map01110] PA-ls K01850 Amino acid metabolism Aromatic amino acid metabolism M00025 Tyrosine biosynthesis, chorismate => tyrosine [PATH:map00400E5.4.99.5 map01230 map01100]chorismate mutase [EC:5.4.99.5] PA-ls K04092 Amino acid metabolism Aromatic amino acid metabolism M00025 Tyrosine biosynthesis, chorismate => tyrosine [PATH:map00400tyrA1 map01230 map01100]chorismate mutase [EC:5.4.99.5] PA-ls K01826 Amino acid metabolism Aromatic amino acid metabolism M00533 Homoprotocatechuate degradation, homoprotocatechuatehpaF, => 2-oxohept-3-enedioate hpcD 5-carboxymethyl-2-hydroxymuconate [PATH:map00350 map01220 map01120] isomerase [EC:5.3.3.10]PA-ls K05714 Amino acid metabolism Aromatic amino acid metabolism M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoAmhpC [PATH:map003602-hydroxy-6-oxonona-2,4-dienedioate map01220 map01120] hydrolase [EC:3.7.1.14]PA-ls K05712 Amino acid metabolism Aromatic amino acid metabolism M00545 Trans-cinnamate degradation, trans-cinnamate => acetyl-CoAmhpA [PATH:map003603-(3-hydroxy-phenyl)propionate map01220 map01120] hydroxylase [EC:1.14.13.127]PA-ls K13832 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoDE, => chorismate DHQ-SDH [PATH:map004003-dehydroquinate map01230 dehydratase map01100 / shikimate map01110 dehydrogenase map01130]shared [EC:4.2.1.10 1.1.1.25] K03786 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoQ, => chorismate qutE [PATH:map004003-dehydroquinate map01230 dehydratase map01100 II [EC:4.2.1.10] map01110 map01130]shared K03856 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4PAROA2, => chorismate aroA [PATH:map004003-deoxy-7-phosphoheptulonate map01230 map01100 synthase map01110 [EC:2.5.1.54] map01130]shared K13829 Amino acid metabolism Aromatic amino acid metabolism M00022 Shikimate pathway, phosphoenolpyruvate + erythrose-4ParoKB => chorismate [PATH:map00400shikimate kinase map01230 / 3-dehydroquinate map01100 map01110 synthase map01130][EC:2.7.1.71shared