DOCUMENT RESUME ED 062 131 SE 013 530 TITLE National Clearinghouse for Drug Abuse Information Selected Reference Series, Series 4, No. 1. INSTITUTION National Inst. of Mental Health, Chevy Chase, Md. National clearinghouse for Drug Abuse Information. PUB DATE Jan 72 NOTE 29 p. AVAILABLE FROM National Clearinghouse for Drug Abuse Information, 5600 Fishers Lane, Rockville, Maryland 20852 EDRS PRICE MF-$0.65 HC-$3.29 DESCRIPTORS Bibliographic Citations; *Drug Abuse; Literature Reviews; Reference Materials; *Reproduction (Biology); *Research ABSTRACT This bibliography, which attempts to gather the significant research on the reproductive effects of the drugs of abuse, is one in a series prepared by the National Clearinghouse for Drug Abuse Information on subjects of topical interest. Selection of literature is based on its currency, its significance in the field, and its availability in local bookstores or research libraries. The goal is to present an overview of the existing literature, but is not meant to be comprehensive or definitive in scope. Citations on this subject are categorized as general articles, cannabis and derivatives, hallucinogens, depressants, narcotics, and other drugs of abuse. The items compiled are directed toward students writing research papers, special interest groups (such as educators, lawyers and physicians), and the general public requiring more resources than public information materials can provide. (BL) U S DEPARTMENT OF HEALTH, EDUCATION & WELFARE OFFICE OF EDUCATION THIS DOCUMENT HAS BEEN REPRO DUCED EXACTLY AS RECEIVED FROM THE PERSON OR ORGANIZATION ORIG MATING IT POINTS OF VIEW OR OPIN IONS STATED DO NOT NECESSARILY REPRESENT OFFICIAL OFFICE OF EDU CATION POSITION OR POLICY SELECTED REFERENCE SERIES SERIES 4, NO. 1 JANUARY 1972 Each bibliography of the National Clearinghouse for Drug Abuse Information Selected Reference Series is a short, representative listing of citations on subjects of topical interest. The selection of literature is based on its currency, its significance in the field, and its availability in local bookstores or research libraries. The scope of the material is directed toward students writing research papers, special interest groups, such as educators, lawyers and physicians, and the general public requiring more resources than public information materials can provide. Each reference series is meant to present an overview of the existing literature, but is not meant to be comprehensive or definitive in scope. THE EFFECT OF THE DRUGS OF ABUSE ON REPRODUCTIVE PROCESSES Introduction The effect of the drugs of abuse on reproductive processes is a largely unresolved research problem at the present time, due to the complex variables involved in the basic and clinical research in this area. Laboratory controls on highly selected animals can be strictly maintained as to dosage level, frequency of dosage and environmental factors. The human abuse of these drugs, however, is uncontrolled and often involves factors such as contaminated drug samples, varying dosage levels at varying frequencies and multiple drug use. Pre-existing genetic damage due to severe illness, medically prescribed drugs, or other medical reasons must also be accounted for in these studies since this is another factor which can lead to inconsistent research results. A final serious concern in studying the reproductive effects of these drugs is the fact that different animal species may have different pharmacologic reactions, which means that a drug could cause genetic damage in labors- tory rsts or other animals but not in man. Therefore, research conclusions based on animal studies must also be checked in humans before broad extrapolations or conclusions can be made. Drugs subject to abuse or non-medical use range from the therapeutically- useful depressants, stimulants and narcotics, like morphine, to the largely abuse-related drugs, such as LSD, cannabis and heroin. Since they are different pharmacologically and chemically, they can effect different parts of the reproductive process and cannot be categorized into one group. Also, therapeutic drugs are prescribed by the physician in safe dosage levels, while the abuse of these drugs is usually in amounts far exceeding the safety zone. This bibliography which attempts to gather the significant research on the reproductive effects of the drugs of abuse must be viewed in relation to the myriad of factors listed above. The inconclusiveness or inconsistency of some of these studies suggests that more research with better methodology needs to be done. These citations can be helpful in outlining past research and the general direction of current studies in this area. TABLE OF CONTENTS Page Introduction 1 General Articles 7 Cannabis and Derivatives 9 Hallucinogens 11 Depressants 21 Narcotics 25 Other Drugs of Abuse 31 GENERAL ARTICLES Apgar, V. Birth defects and the newborn. Word, February, 1969. Apgar, V. Drugs in pregnancy. Journal of the American Medical Associa- tion, 190(9):840-841, 1964. Reprint is available from the National Foundation March of Dimes. Baker, J. B. E. The effects of drugs on the foetus. Pharmacological Review, 12(3):37-90, 1960. Bartholomew, A. A., and Sutherland, G. Alcoholism, drug dependency and sex chromosome abnormalities. Medical Journal of Australia, 2(9): 440-443, 1969. Behrendt, H. Diagnosis of autonomic disorders of the neonate. Pro- ceedings of the Rudolph Virchow Medical Society in the City of New York, 23:94-96, 1966. Blane, G. F. Oxygen consumption in the new-born rat and the effects of administered analgesics. British Journal of Pharmacy and Chemotheraphy, 30(3):478-487, 1967. Brazelton, T. B. Effect of prenatal drugs on the behavior of the neo- nate. American Journal of Psychiatry, 126:1261-1266, March, 1970. Caruana, S. Drug abuse and pregnancy. Midwives Chronicle, 81:4-11, January, 1968. Cohen, M. M. The interaction of various drugs with human chromosomes. Canadian Journal of Genetic Cytology, 11:1-24, March, 1969. Duarte- Contreras A., et al. /Drugs that affect the fetus./ (Spa) Revista Colombiana de Obstetricia y Ginecologia, 20:309-325, September, 1969. Epstein, S. S.; Lederberg, J.; Legator, M.; Carroll, E. E.; and Blaine, J. D. Drugs of Abuse: Their Genetic and Other Nonpsychiatric Hazards. Cambridge, Mass.: MIT Press, 1971. Gleiss, J. Teratogenicity of soporific drugs. German Medical Monthly, 14:202-203, April, 1969. Gleiss, J. /Reflections on the teratogenicity of hypnotics./ (Ger) Deutsche Medizinische Wochenschrift, 93:1732-1734, September 6, 1968. Meester, W. D. The effects on the fetus of drugs given during preg- nancy. Marquette Medical Review, 30(4):147--154, 1964. Reprint is available from The National Foundation March of Dimes. Nielsen, J.; Friedrich, U.; and Tsuboi, T. /Chromosome abnormalities and psychopharmaceutical drugs./ (Dan) Ugeskrift for Laeger, 130: 1527-1528, September 12, 1968. Neuberg, R. Drug dependence and pregnancy:. a review of the problems and their management. Journal of Obstetrics and Gynaecology, Bri- tish Commonwealth, 77:1117-1122, December, 1970. Shane, J. M. Congenital anomalies secondary to maternal drug ingestion. Journal of the Oklahoma Medical Association, 61:529-532, November, 1968. Stoffer, S. S. A gynecologic study of drug addicts. American Journal of Obstetrics and Gynecology, 101:779-783, July 15, 1968. Ward, C. 0., and Gautieri, R. F. Effect of certain drugs on perfused human placenta. VI. Serotonin antagonists. Journal of Pharma- ceutical Science, 55:474-478, May, 1966. CANNABIS AND DERIVATIVES Carakushansky, G.; Neu, R. L.; and Gardner, L. I. Lysergide and cannabis as possible teratogens in man. Lancet, 1:150-151, January 18, 1969. Cannabis--yet another teratogen. British Medical Journal, 1:797, March 29, 1969. Geber, W. F, and Schramm, L. C. Teratogenicity of marihuana extract as influenced by plant origin and seasonal variation. Archives Interna- tionales de Pharmacodynamie et de Therapie, 177:224-230, January, 1969. Geber, W. F, and Schramm, L. C. Effect of marihuana extract on fetal hamsters and rabbits. Toxicology and Applied Pharmacology, 14:276-282, March, 1969. Harbison, R. D. Maternal distribution and placental transfer of C-14 delta 9-tetrahydrocannabinol in pregnant mice. Toxicology and Applied Pharmacology, 19(2):413-414, 1971. Hecht, F.; Beals, R. K.; Lees, M. H.; Jolly, H.; and Roberts, P. Lysergic- acid-diethylamide and cannabis as possible teratogens in man. Lancet, 11:1087, November 16, 1968. Idanpaan-Heikkila, J.; Fritchie, G. E.; Englert, L. F.; Ho, B. T.; Mclsaac, W. M. Placental transfer of tritiated-l-6-9-tetrahydrocannabinol. New England journal of Medicine, 281(6):330, 1969. Kennedy, J. S., and Waddell, W. J. Whole body autoradiography of the pregnant mouse after administration of C14-A 9-tetrahydrocannabinol (419-THC). Federation Proceedings, 30(2):279, 1971. Lieberman, C. M., and Lieberman, B. W. Current concepts: marihuana -- a medical review. New England Journal of Medicine, 284:88-91, January 14, 1971. Miras, C. J. Hashish: Its Chemistry and Pharmacology. Wolstenholme, 6. E. W. and Knight, J., eds. Boston: Little, Brown, 1965, pp. 37-52. Martin, P. A. Cannabis and chromosomes. Lancet, 1(7590):370, 1969. Myers, W. A. LSD and marijuana: where are the answers. Science, 160: 1062, June 7, 1968. Neu, R. L.; Powers, H.; Kings S.; and Gardner, L. I. Cannabis and chro- mosomes. Lancet, 1(7596):675, 1969. Persaud, I., and Ellington, A. Cannabis in early pregnancy. Lancet, 2(7529):1306, 1967. Persaud, I., and Ellington, A. Teratogenic activity of cannabis resin. Lancet, 2(7564):406-407, 1968. Persaud, T. V. N., and Ellington, A. C. The effects of Cannabis sativa L. (ganja) on developing rat embryos--preliminary observations. West Indian Medical Journal, 17:232-234, December, 1968. HALLUCINOGENS Aase, J. M.; Laestadius, N.; and Smith, D. W. Children of mothers who took L.S.D. in pregnancy. Lancet, 1(7663):100-101, July 11, 1970. Abbo, G.; Norris, A.; and Zellweger, H. Lysergic acid diethylamide (LSD- 25) and chromosome breaks. Humangenetik, 6(3):253-258f 1968. Alexander, G. J., and Miles, B. E. LSD: injection early in pregnancy produces abnormalities in offspring of rats. Science, 157:459-460, July 28, 1967.