Supplemental Table S1. Genes differentially expressed in ovary of old rhesus monkeys vs. young and middle-age monkeys Old vs. Young Old vs. Middle-age q-value* Fold Differentially q-value Fold Differentiall Gene Name Gene Symbol RefSeq Transcript ID (%) Change expressed (%) Change y expressed Similar to Cofilin-1 (Cofilin,LOC721819 non-muscle4.495104 isoform) 26.8915 + - - - XM_001096328XR_014660 /// XM_001096451 /// melanocortin 2 receptorMRAP accessory protein4.646275 22.8616 + - - - XM_001096562 /// XM_001096665 /// XM_001096774 chitinase 1 (chitotriosidase)CHIT1 3.396112 12.2749 + - - - XM_001102929 /// XM_001103012 chromosome 4 openMGARP reading frame 49 ortholog4.7194 7.4128 + - - - XM_001087713 similar to WNT1-inducibleLOC717872 signaling pathway3.431917 protein 7.00412 precursor (WISP-2)+ (Connective- tissue- growth factor-like- protein)XM_001109859 (CTGF-L) (Connective tissue growth factor-related protein 58) potassium voltage-gatedKCNB1 channel, Shab-related1.590142 subfamily,5.8293 member+ 1 - - - XM_001098678 Similar to peptidylprolylLOC707078 isomerase A isoform2.453362 1 5.2929 + - - - XR_011674 matrix metallopeptidaseMMP9 9 (gelatinase 2.735892B, 92kDa gelatinase,5.2734 92kDa +type IV collagenase)- - - XM_001104871 similar to mannan-bindingLOC708206 lectin serine4.257852 protease 1 isoform5.1997 2 precursor+ - - - XR_012871 Similar to profilin 1 LOC706963 4.257852 5.0668 + - - - XR_011653 XM_001083742 /// XM_001083847 /// similar to acyl-CoA synthetaseLOC694871 long-chain4.495104 family member4.5633 1 + - - - XM_001083961 /// XM_001084069 /// XM_001084192 /// XM_001084305 Hypothetical proteinLOC701880 LOC701880 4.257852 4.5056 + - - - XM_001090162 aldolase C, fructose-bisphosphateALDOC 4.257852 4.3805 + - - - XM_001107579 /// XM_001107637 metallothionein 2A MT2A 4.495104 4.2412 + - - - XM_001092096 similar to dedicator LOC698081of cytokinesis 8 4.257852 4.2226 + - - - XR_011087 transmembrane proteinTMEFF2 with EGF-like 4.495104and two follistatin-like3.8991 domains+ 2 - - - XM_001116616XM_001084739 /// XM_001116629XM_001084859 /// similar to fatty acid desaturaseLOC719037 2 4.495104 3.7342 + - - - XM_001116637 similar to phosphatidicLOC715993 acid phosphatase4.646275 type 2B 3.5695 + - - - XM_001114350 /// XM_001114366 small-conductance calcium-activatedSK3 potassium2.735892 channel3.5035 + - - - XM_001112021 heat shock 22kDa proteinHSPB8 8 4.495104 3.4527 + - - - NM_001032937 Similar to Cadherin-relatedLOC702800 tumor suppressor4.257852 homolog3.3358 precursor (Protein+ fat homolog)- - - XM_001086942XR_011069 /// XM_001087065 /// copine VIII CPNE8 4.495104 3.1142 + - - - XM_001087185 C-type lectin domainCLEC1A family 1, member4.495104 A 2.9213 + - - - NM_001042638XM_001114932 /// XM_001105696 /// XM_001105767 /// XM_001105824 /// Thy-1 cell surface antigenTHY1 4.495104 2.8757 + - - - XM_001105894 XM_001090473 /// XM_001090590 /// similar to aspartate LOC699884beta-hydroxylase isoform b0 2.8073 + - - - XM_001090710 /// XM_001090824 Hypothetical proteinLOC716818 LOC716818 4.495104 2.8029 + - - - XM_001107783 Similar to phospholipaseLOC718418 C beta 4 isoform2.735892 a 2.5773 + - - - XR_014465 similar to family withLOC718937 sequence similarity4.495104 20, member2.5589 A + - - - XM_001116963 similar to ras-like proteinLOC717769 TC10 4.495104 2.5486 + - - - XM_001109631 tissue factor pathwayTFPI inhibitor 4.646275 2.5296 + - - - XM_001104806 similar to Myosin regulatoryLOC709784 light chain4.222205 2, smooth muscle2.5159 isoform (Myosin+ RLC) -(LC20) (Myosin- regulatory- light chainXR_012098 9) ButyrylcholinesteraseBCHE 4.756981 2.4292 + - - - XM_001086643XR_011736 /// XM_001087117 /// Similar to TBC1 (tre-2/USP6,LOC697357 BUB2, cdc16)4.495104 domain 2.2916family, member+ 1 - - - XM_001087581 insulin-like growth factorIGFBP4 binding protein4.495104 4 2.2457 + - - - XM_001097914 XM_001102580 /// XM_001102666 /// similar to cysteine sulfinicLOC701290 acid decarboxylase-related4.257852 2.2242 protein 2 + - - - XM_001102752 /// XM_001102845 similar to protein tyrosineLOC703937 phosphatase, receptor4.7194 type,2.1583 G precursor+ - - - XR_011208 Similar to PML-RARALOC712017 regulated adaptor4.495104 molecule 1 2.1566 + - - - XR_012548 XM_001101963 /// XM_001102052 /// hyaluronoglucosaminidaseHYAL1 1 4.495104 2.0921 + - - - XM_001102143 /// XM_001102231 /// XM_001102322 /// XM_001102414 Rho guanine nucleotideARHGEF12 exchange factor4.257852 (GEF) 12 1.9327 + - - - XR_012563 coatomer protein complex,COPZ2 subunit zeta4.646275 2 1.9702 + - - - XM_001084942 similar to cytochromeLOC696520 P450, family 4, subfamily4.7194 v, polypeptide1.9159 2 + - - - XM_001088961 chromosome 5 openNADKD1 reading frame 333.010359 ortholog 1.8107 + - - - XM_001114539XM_001092624 /// XM_001114565 /// XM_001114600 /// XM_001114624 /// similar to pre-B-cell LOC717036leukemia transcription2.735892 factor interacting1.5683 protein+ 1 - - - XM_001114649 RAP1A, member of RAP1ARAS oncogene family4.7194 1.5621 + - - - XM_001106027 cell cycle progressionCCPG1 1 4.222205 1.998 + - - - XM_001087398 Similar to ring fingerLOC707577 protein 137 4.495104 1.9885 + - - - XR_012891 similar to Epithelial membraneLOC717867 protein 4.2222053 (EMP-3) (YMP1.9722 protein) (Hematopoietic+ -neural membrane- protein)- (HNMP-1)XM_001113524 similar to PDZ domainLOC709901 containing RING finger4.7194 3 1.7813 + - - - XM_001109785XM_001098466 /// XM_001109832 /// XM_001109878 /// XM_001109925 /// similar to cAMP-dependentLOC712474 protein kinase3.431917 inhibitor gamma1.7564 + - - - XM_001109963 /// XM_001110008 /// XM_001110061 ring finger protein 13RNF13 4.495104 1.8883 + - - - XM_001108379 hypothetical protein LOC710818LOC710818 4.7194 1.9368 + - - - XR_012295 Similar to peptidaseLOC714817 (prosome, macropain)4.495104 26S subunit,1.6799 ATPase 1+ - - - XR_013065 hypothetical protein LOC717131LOC717131 4.495104 1.7822 + - - - XM_001108353 similar to Endoglin precursorENG (CD105 antigen)4.646275 1.9318 + - - - XR_011598 septin 11 S EPT11 4.495104 1.9907 + - - - XM_001093263 /// XM_001093370 similar to meningiomaLOC713280 1 4.495104 1.995 + - - - XR_012573 similar to HomeoboxLOC710591 protein Nkx-3.1 4.495104 1.799 + - - - XM_001115853XM_001106266 /// XM_001115861XM_001106332 /// similar to activating LOC719150transcription factor4.646275 5 1.5342 + - - - XM_001115871 coiled-coil domain containingCCDC85B 85B 4.495104 1.5389 + - - - XM_001112215 XM_001106942 /// XM_001107009 /// similar to Kruppel-likeKLF7 factor 7 (ubiquitous)4.495104 1.8212 + - - - XM_001107070 /// XM_001107137 X-ray repair complementingXRCC6 defective repair2.46188 in Chinese0.4987 hamster cells+ 6 - - - XM_001105684 SWI/SNF-related matrix-associatedSMARCC1 actin-dependent1.022234 0.4967 regulator of chromatin+ c1 - - - XR_012360 XM_001107514 /// XM_001107572 /// hypothetical protein LOC711168LOC711168 0.526605 0.4966 + - - - NM_001042783XM_001107633 /// XM_001109413 /// XR_009653 /// XR_009774 /// XR_010989 /// similar to HeterogeneousHNRPA1 nuclear ribonucleoprotein3.010359 A10.4954 (Helix-destabilizing+ protein)- (Single-strand- RNA-binding- protein)XR_011222 (hnRNP /// XR_011984 core protein /// A1) XR_012371 (HDP) /// similar /// to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) /// hypothetical protein LOC693386 /// heterogeneous nuclear ribonucleoprotein A1 /// hypothetical protein LOC711756 /// hypothetical protein LOC716204 XR_013205 /// XR_013276 /// XR_013977 /// XR_014497 similar to jumonji, ATLOC702291 rich interactive domain1.362979 2 protein0.4946 + - - - XR_011465 arginyl-tRNA synthetaseRARS2 2, mitochondrial3.181323 0.4936 + - - - XM_001092575 XM_001103696 /// XM_001103783 /// XM_001103954 /// XM_001104045 /// similar to CG15120-PALOC715522 0 0.4913 + - - - XM_001104130 /// XM_001104213 /// XM_001104292 general transcriptionGTF3C4 factor IIIC, polypeptide4.114412 4, 90kDa0.4909 + - - - XM_001104736 XM_001113088 /// XM_001113121 /// similar to tripartite motif-containingLOC711397 45 2.46188 0.4906 + - - - XM_001113153 THAP domain containingTHAP9 9 2.92445 0.4888 + - - - XM_001086766 downstream neighborDONSON of SON 4.495104 0.4847 + - - - XM_001090910 /// XM_001091031 XM_001088290 /// XM_001088611 /// similar to exonucleaseLOC696366 NEF-sp 4.048115 0.4793 + - - - XM_001088716 /// XM_001088838 /// XM_001088943 /// XM_001089058 similar to TBP-associatedLOC704624 factor 1A isoform3.495013 1 0.4747 + - - - XR_012571 hypothetical protein LOC695614LOC695614 ////// LOC704319similar1.775852 to Nucleosome /// LOC7146790.4734 assembly+ protein 1-like- 1 (NAP-1-related- protein)- (hNRP)XR_010359 /// similar /// to XR_012282 Nucleosome /// assembly XR_013032 protein 1-like 1 (NAP-1-related protein) (hNRP) similar to Splicing factor,LOC712439 proline- and glutamine-rich2.273754 0.4701(Polypyrimidine+ tract-binding- protein-associated- splicing- factor)XR_012628 (PTB-associated splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100-kDa DNA-pairing protein) (hPOMp100... XM_001095114 /// XM_001095455 /// similar to Protein C21orf59C3H21orf59 4.114412 0.4672 + - - - XM_001095667 /// XM_001095768 /// XM_001095882 similar to polyamine-modulatedLOC711508 factor 12.46188 0.4669 + - - - XM_001105501 /// XM_001105574 melanoma antigen familyMAGED4B D, 4B 3.495013 0.4641 + - - - XM_001085892 XM_001113695 /// XM_001113722 /// XM_001113748 /// XM_001113774 /// XM_001113795 /// XM_001113822 /// similar to COP9 constitutiveLOC712697 photomorphogenic4.7194 homolog0.4633