Aus der Klinik und Poliklinik für kleine Haustiere des Fachbereichs Veterinärmedizin der Freien Universität Berlin A 6-year Retrospective Study of Canine Gastric Dilatation- Volvulus Treated with Incorporating Gastropexy Inaugural-Dissertation zur Erlangung des Grades eines Doktors der Veterinärmedizin an der Freien Universität Berlin vorgelegt von Kriangkrai Thongkorn Tierarzt aus Buriram, Thailand Berlin 2012 Journal-Nr. 3588 Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin der Freien Universität Berlin Dekan: Univ.-Prof. Dr. Leo Brunnberg Erster Gutachter: Univ.-Prof. Dr. Leo Brunnberg Zweiter Gutachter: Univ.-Prof. Dr. Jürgen Zentek Dritter Gutachter: Univ.-Prof. Dr. Johannes Handler Deskriptoren (nach CAB-Thesaurus): dogs, stomach diseases, surgical operations, retrospective studies, laparotomy Tag der Promotion: 26.11.2012 Bibliografische Information der Deutschen Nationalbibliothek Die Deutsche Nationalbibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; detaillierte bibliografische Daten sind im Internet über <http://dnb.ddb.de> abrufbar. ISBN: 978-3-86387-241-0 Zugl.: Berlin, Freie Univ., Diss., 2012 Dissertation, Freie Universität Berlin D 188 Dieses Werk ist urheberrechtlich geschützt. Alle Rechte, auch die der Übersetzung, des Nachdruckes und der Vervielfältigung des Buches, oder Teilen daraus, vorbehalten. Kein Teil des Werkes darf ohne schriftliche Genehmigung des Verlages in irgendeiner Form reproduziert oder unter Verwendung elektronischer Systeme verarbeitet, vervielfältigt oder verbreitet werden. Die Wiedergabe von Gebrauchsnamen, Warenbezeichnungen, usw. in diesem Werk berechtigt auch ohne besondere Kennzeichnung nicht zu der Annahme, dass solche Namen im Sinne der Warenzeichen- und Markenschutz-Gesetzgebung als frei zu betrachten wären und daher von jedermann benutzt werden dürfen. This document is protected by copyright law. No part of this document may be reproduced in any form by any means without prior written authorization of the publisher. Alle Rechte vorbehalten | all rights reserved © Mensch und Buch Verlag 2012 Choriner Str. 85 - 10119 Berlin [email protected] – www.menschundbuch.de CONTENTS……………………………………………...……………………………………….I ABBREVIATIONS………………………………………………….……………………..…..IV LIST OF FIGURES……………………………………………………………………...…..VIII LIST OF TABLES………………………………………………………………………….…..IX CONTENTS 1. Introduction………………………………………………………………………….……. 1 2. Review Literature…………………………………………………………..………….…. 3 2.1 Etiologies of Gastric Dilatation-Volvulus (GDV)………………...……………….…. 3 2.2 Pathophysiology of GDV…………………………………………………………..…. 4 2.3 Diagnosis of GDV…………………………………………………………………….. 5 2.3.1 Signalment………………………………………………………………….… 5 2.3.2 History……………………………………………………………………..….. 5 2.3.3 Physical Examination Findings……...……………………………………....... 6 2.3.4 Radiography…………………………………………………………...……… 6 2.3.5 Laboratory Findings………………...………………………………………… 7 2.4 Medical Treatment of GDV…………………………………………………………... 8 2.5 Surgical Treatment of GDV………………………………………………………..…. 9 2.5.1 Methods of Gastropexy………………...……………………………...…….... 9 2.5.1.1 Tube Gastropexy…………...…………………………………………....... 9 2.5.1.2 Circumcostal Gastropexy……..……………………………………….… 10 2.5.1.3 Muscular Flap (Incisional) Gastropexy……………………………...….. 10 2.5.1.4 Belt-Loop Gastropexy………………………………………………...…. 10 2.5.1.5 Incorporating Gastropexy ………………………………………….…… 11 2.5.1.6 Gastrocolopexy…………………………………………………..……… 12 2.5.1.7 Laparoscopic Prophylactic Gastropexy………………………….……… 12 2.5.1.8 Minilaparotomy Prophylactic Gastropexy………………………….…… 12 I 2.6 Postoperative Care of GDV…………………………………………………………. 12 3. Materials and Methods………………………………………………………………..…. 15 3.1 Subjects……………………………………………………………………...………. 15 3.2 Study Design and Method of Data Collection….……………………...……………. 15 3.3 Standard Procedures…………………………………………………………...…….. 16 3.3.1 Standard Medical Treatment……………………..……………………..…… 16 3.3.1.1 Patient Stabilization…………...…………………………………...……. 16 3.3.1.2 Blood Collection………..…………………………………………….…. 17 3.3.1.3 Fluid Therapy……………..………….……………………………….…. 17 3.3.1.4 EKG……………………………………………………………………... 18 3.3.1.5 Antibiotics……………………………………………………………..… 20 3.3.1.6 Corticosteroids………………………………………………………..…. 20 3.3.1.7 Oxygen Therapy………………...………………………………….……. 21 3.3.1.8 Decompression……………………………………………………….…. 2 1 3.3.1.8.1 Orogastric Tube…………..……………………………………... 2 1 3.3.1.8.2 Percutaneous…………………………………………………….. 21 3.3.2 Standard Radiography…...…………………………………………….…….. 22 3.3.3 Standard Anesthesia………...……………………………………………..… 22 3.3.4 Emergency Corrective Surgery………...…………………………………..... 23 3.3.4.1 Assessment of Stomach and Surrounding Organs…..………………..…. 24 3.3.4.2 Repositioning of Stomach…………………………………………..…… 26 3.3.4.3 Incorporation Gastropexy Technique.…………………………….…….. 2 6 3.3.5 Post-operative Care………………...…………………………………..……. 26 3.4 Statistical Analysis……...………………………………………………………...…. 28 4. Results…………………………………………………………………………………… 29 4.1 Signalments………………………………………………………………………….. 29 4.2 Clinical Signs……………...………………………………………………………… 43 4.3 Radiographic Findings……………...………………………………………..……… 45 4.4 Preoperative Hematological and Biochemical Findings….………………….…….... 46 4.4.1 Complete Blood Count………..………………………………..…………… 4 6 4.4.2 Coagulation Profiles……………………………………………………….… 49 4.4.3 Biochemical Finding…………...…………………………………………..... 51 4.5 Surgical Finding………...………………………………………………...…………. 54 4.6 Outcomes……………………………………………………………………………. 56 4.7 Complications………………………………………………………………..……… 56 4.8 Previous Surgery or Sickness…………………...……………………………..…….. 56 II 5. Discussion……………………………………………………………………………….. 59 6. Summary…………………………………………………………………………..…….. 63 7. Zusammenfassung…………………………………………………………………..…… 65 8. References……………………………………………………………………………….. 67 9. Acknowledgements……………………………………………………………………… 79 10. Selbständigkeitserklärung………………………………………………………...…..…. 8 0 III Abbreviations µg Microgram Alb Albumen ALT Alanine Aminotransferase AP Alkaline Phosphatase aPTT Activated Partial ThromboplastinTtime AST Aspartate Aminotransferase AT III Antithrombin III BID Twice a Day (bis in die) Bili Bilirubin bpm Beat per Minute BUN Blood Urea Nitrogen Ca Calcium Ca++ Ionized Calcium CBC Complete Blood Count Cho Cholesterol CK Creatine Kinase cm Centimeter IV df Degree of Freedom DIC Disseminated Intravascular Coagulopathy EKG/ECG Electrocardiogram GA Gauge GD Gastric Dilatation GDV Gastric Dilatation-Volvulus GLDH Glutamate Dehydrogenase Glu Glucose h Hour IBD Inflammatory Bowel Disease IM Intramuscular IV Intravenous K Potassium kg Kilogramm MCH Mean Corpuscular Haemoglobin MCHC Mean Corpuscular Haemoglobin Concentration MCV Mean Corpuscular Volume Mg Magnesium mg Milligramm min. Minute V ml Milliliter mm Millimeter mmol/L Millimoles/liter MRSA Methicillin-Resistant Staphylococcus aureus Na Sodium OR Odd Ratio P Phosphorus PASW Predictive Analytics Software PCV Packed Cell Volume PO Per os Pro Protein PT Prothrombin Time PVCs Premature Ventricular Contractions q Every (quaque) QID Four Times a Day (quater in die) RBC Red Blood Cell SC Subcutaneous SID Once a Day (semel in die) TDWRs Thoracic Depth and Width Ratios TID Three Times a Day (ter in die) VI VES Ventricular Extrasystoles WBC White Blood Cell χ² Chi-square VII List of figures Figure 1 : Right lateral abdominal radiograph of a GDV dog………………………….….…. 7 Figure 2 : Incorporating gastropexy…………………………………………………..……… 11 Figure 3 : Intraveonos catheter, 16 gauge……………………...……………………..………16 Figure 4 : Crystalloid and colloid infusions……………………......................………………18 Figure 5 : Perioperative continuous electrocardiography and vital signs monitoring……...... 19 Figure 6 : EKG of a premature ventricular contractions (PVCs)…………………..…….… 20 Figure 7 : A warm air ventilator machine (Bair Hugger)®………………………...…….….. 23 Figure 8 : Extensive necrotic area of the twisted stomach in a GDV dog………………...…. 25 Figure 9 : Plasma transfusion……………………………………………………………..…..28 Figure 10 : Sex distribution among patients showing GDV-involved symptoms………….... 31 Figure 11 : Age distribution at the time of presentation…………………………………..…. 32 Figure 12 : Weight groups and sex distribution of dogs presenting with GDV syndrome…...35 Figure 13 : Breed groups and sex distribution of dogs presenting with GDV syndrome…....39 Figure 14 : Treatment groups and outcomes of 181 dogs presenting with GDV syndrome....42 VIII List of tables Table 1: Dogs presenting with GDV syndrome………………………………………….…..30 Table 2: Sex distribution among GDV-involved symptom patients…………………………30 Table 3 : Age groups and outcome ( discharge vs death or euthanasia) of overall morbidity..33 Table 4 : Descriptive statistics of age and body weight……………………………………....34 Table 5 : Weight groups and sex distribution of dogs presenting with GDV syndrome…..... 34 Table 6 : Incidence of GDV-involved symptom patients in pure breed dogs and mongrels...37 Table 7 : Breed group and sex distribution of dogs presenting with GDV syndrome……….38 Table 8 : Number and percentage of dogs with GDV-involved symptoms…………………..40 Table 9 : Treatment of dogs presenting with GDV syndrome……...…………………...……40 Table 10 : Treatment groups and outcomes of 181 dogs presenting with GDV syndrome…. 41 Table 11 : The descriptive statistics of clinical signs…………………………………………44 Table 12 : Clinical signs of of 181 dogs presenting with GDV syndrome………………...…44 Table 13 : Radiographic findings of dogs presenting with GDV syndrome………………….45 Table 14 : Numbers of dogs radiographically screened for GDV and other associated radiographic findings……………………………………………………………………….... 46 Table