Magic™ Anti-TSHB monoclonal antibody, clone C2657N (DCAB-TJ182) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The a Specificity Recognizes beta subunit of human TSH. Immunogen TSH from human pituitary gland. Isotype IgG1 Source/Host Mouse Species Reactivity Human Clone C2657N Purification > 90% pure (SDS-PAGE). Protein A Chromatography Conjugate Unconjugated Applications Suitable for use in ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded. Capture Detection DCAB- Suggested pair for testing (Capture - Detection): DCAB-TJ182 - DCAB-TJ181 Procedure Matched Antibody Pairs Format Purified, Liquid Concentration Lot Specific mg/mL (OD280 nm, E0.1% = 1.4) Buffer PBS, pH 7.4 Preservative 0.1% Sodium Azide Storage Store at 2-8°C. Warnings Centrifuge before opening to ensure complete recovery of vial contents. This product contains 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains. GENE INFORMATION Gene Name TSHB thyroid stimulating hormone, beta [ Homo sapiens (human) ] Official Symbol TSHB Synonyms TSHB; thyroid stimulating hormone, beta; TSH-B; TSH-BETA; thyrotropin subunit beta; thyrotropin beta chain; Thyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; Thyrotropin beta chain; Thyrotropin alfa Entrez Gene ID 7252 Protein Refseq NP_000540 UniProt ID P01222 Chromosome Location 1p13 Pathway Amine-derived hormones, organism-specific biosystem; Autoimmune thyroid disease, organism- specific biosystem; Autoimmune thyroid disease, conserved biosystem; Class A/1 (Rhodopsin- like receptors), organism-specific biosystem; G alpha (s) signalling events Function hormone activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.