(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/140629 Al 9 September 2016 (09.09.2016) P O P C T (51) International Patent Classification: (74) Agent: BULUT, Pinar; FarmaPatent Limited Sirketi, A61K 36/28 (2006.01) A61P 17/02 (2006.01) GMK Bulvari No:42/5, Maltepe, 06440 Ankara (TR). A61K 36/38 (2006.01) A61P 23/00 (2006.01) (81) Designated States (unless otherwise indicated, for every A61K 31/167 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/TR20 15/000088 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 5 March 2015 (05.03.2015) KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (25) Filing Language: English MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: PHARMACTFVE ILAC SANAYI VE Tl- TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. CARET A. S. [TR/TR]; Mahmutbey Mah. Dilmenler Cad., (84) Designated States (unless otherwise indicated, for every Aslanoba Plaza No: 19 K:3, Bagcilar/istanbul (TR). kind of regional protection available): ARIPO (BW, GH, (72) Inventors: YILDIRIM, Ersin; Pharmactive Ilac Fabrikasi, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Ataturk Mah. Fatih Blv. No: 32 QOSB, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Cerkezkoy/Tekirdag (TR). KARASU, Tolga Ramazan; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Pharmactive Ilac Fabrikasi, Ataturk Mah. Fatih Blv. No:32 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, COSB, Cerkezkoy/Tekirdag (TR). GURPINAR, Hakan; LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Pharmactive Ilac Fabrikasi, Ataturk Mah. Fatih Blv. No:32 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, COSB, Cerkezkoy/Tekirdag (TR). SOLMAZ, Mustafa GW, KM, ML, MR, NE, SN, TD, TG). Serkan; Pharmactive Ilac Fabrikasi, Ataturk Mah. Fatih Published: Blv. No: 32 QOSB, Qerkezkoy/Tekirdag (TR). — with international search report (Art. 21(3)) (54) Title: A TOPICAL COMPOSITION COMPRISING CALENDULA, HYPERICUM AND LIDOCAINE (57) Abstract: The present invention relates to the topical composition comprising Calendula officinalis, Hypericum perforatum and a local anesthetic. A TOPICAL COMPOSITION COMPRISING CALENDULA, HYPERICUM AND LIDOCAINE DESCRIPTION Field of the Invention The present invention relates to the topical composition comprising Calendula officinalis, Hypericum perforatum and a local anesthetic; that can be used for the treatment and the cure of external lesions, which have wound healing, antiseptic, anti-bacterial, anti-inflammatory and pain relieving properties. Background of the Invention Calendula or marigold has been used since the time of the Greeks as a skin balm and anti¬ inflammatory. Calendula (Gold-Bloom ) marigold, is a genus of about 12-20 species annual or perennial herbaceous plants in the daisy family Asteraceae, native to an area from Macaronesia east through the Mediterranean to Iran. It is commonly used for skin conditions including minor abrasions and burns, conjunctivitis, aphthous stomatitis, pharyngitis, hemorrhoids, diaper rashes and ulcers. In addition, marigold has been shown to increase blood circulation and to aid in healing blood stagnation bruises. Experimental in vivo research suggests that marigold gently stimulates the immune system and promotes lymphatic drainage as well as reducing inflammation and pain. Calendula ointment Unguentum "Calendula" which contains tincture of calendula (on 70% spirit 1:10)-20 g, vaseline-90 g: [Mashkovskij M. V . "Medicinal Means", Moscow, "Medicine" 1986, vol. 2, p. 2.424] (US 5997876 CI.1, Ln.7-15). St. John's wort or Hypericum has been used to treat many ailments, including cuts, grazes, bruises, minor bums, sciatica, injured nerves, inflammations, ulcers, poisonous reptile bites, kidney and lung ailments, allergic reactions, anxiety and depression. In addition, St. John's wort is also a good source of antioxidants: with 11.7% of its content being bioflavonoids such as rutin, hyperoside, quercetin and quercrtrin, St. John's wort is one of the most concentrated herb sources of antioxidants. There is also known "Ointment Kolkhuri", which contains St.John's-wort, the oak bark, haw- thorn, yarrow, yellow melilot, horse-chestnut 0.06-0.065 in equal quantity, nettle 0.10-0. 11, gum- tree extract 0.02, belladonna extract 0.02, vaseline-the rest; [GE 13, Oarsania, V. 15.05.94]. (US 5997876 CI.1, Ln.17-35). This ointment is used as analgetic and antiinflammatory means and is less effective for healing the wounds and burns, as haw-thorn and belladonna arc not characterized by antiinflammatory and regeneration stimulating effect. Local anaesthetic is a type of medication used to numb areas of the body. Local anaesthetic causes a complete loss of pain sensation to a specific area of body without losing consciousness. It works by blocking the nerves from the affected part of body so that signals can't reach the brain. It only takes a few minutes to lose feeling in the area where local anaesthetic is given. Medical uses are acute pain, chronic pain, surgery, podiatry, dentistry, painless venipuncture and some endoscopic procedures such as bronchoscopy (visualization of the lower airways) or cystoscopy (visualization of the inner surface of the bladder). Topical anaesthesia contains local anaesthetic and is available over the counter from pharmacists in the form of creams, sprays and ointments. W01 997/42963 describes an ointment used in the treatment of burnings and skin diseases that includes some types of plants such as Chelidonium majus, Plantago major, Matricaria chamomilla, Achillea millefolium, Calendula officinalis, Hypericum perforatum, Eucalyptus globus, Oleum olivarum and yellow beewax of Cera flava. WO2005/063266 describes a composition for topical use that uses the extract of Calendula officinalis and Hypericum perforatum that they include peptides of low molecular weight and free aminoacids. Described composition in this document is destined for the treatment of psoriasis. Despite the lots of known therapeutical compositions, the problems in treating wound, still exist since these drugs available are not sufficient to improve conditions and alleviate symptoms like epithelial damage, stinging, inflamation. There is a need for improvement of the known drugs due to fast and complete healing requisites. Summary of the Invention The present invention relates to topical application of a safe pharmaceutical composition comprising Calendula officinalis, Hypericum perforatum and a local anesthetic; that can be used for the treatment and the cure of external lesions, which have wound healing, antiseptic, anti¬ bacterial, anti-inflammatory and pain relieving properties. Disclosure of the Invention The present invention provides a topical pharmaceutical composition comprising Calendula officinalis, Hypericum perforatum and a local anesthetic. In one embodiment, topical pharmaceutical composition of present invention contains Calendula officinalis which can be used in the form of essential oil or alcoholic or non-alcoholic extract thereof. In one embodiment, topical pharmaceutical composition of present invention contains Hypericum perforatum which can be used in the form of essential oil or alcoholic or non¬ alcoholic extract thereof. Local anesthetics belong to one of two classes: aminoamide and aminoester local anesthetics. Ester class local anesthetics are prone to producing allergic reactions, which may necessitate the use of an amide class. In one embodiment, in the present invention, local anesthetics can be selected from the group consisting of Benzocaine, Chloroprocaine, Cyclomethycaine, Dimethocaine, Piperocaine, Propoxycaine, Procaine, Proparacaine, Tetracaine, Articaine, Bupivacaine, Cinchocaine, Etidocaine, Levobupivacaine, Lidocaine, Mepivacaine, Prilocaine, Ropivacaine, Trimecaine and pharmaceutical acceptable salts thereof. In the preferred embodiment, in the present invention, local anesthetic is selected from amide class due to safety reasons. More preferably, local anesthetic is lidocain in the form of base or acid addition salts thereof. Lidocaine is a well known and commercially available local anesthetic of amide class. It is widely used to treat pain and itching associated with insect bites, sunburn, contact dermatitis, and in connection with anal-rectal conditions such as hemorrhoids, fissures and infections. In one embodiment of present invention, the topical anesthetic material is disposed in a carrier which is a cream, lotion or gel, and in many instances, liposomal structures are particularly favored carriers. As is known in the art, liposomal structures comprise vesicles having walls formed from a phospholipid or similar material. In certain embodiments of the present invention, topical pharmaceutical composition is in the form of external preparations, such as ointments, creams, gels, lotions, liquids, sprays, cataplasmas, tapes, preferably in the form of gel. In certain embodiments of the present invention, in addition to the herbal active ingredients described above, topical pharmaceutical composition optionally