DIABLO blocking peptide (CDBP6162) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] Immunogen 15 amino acids near the carboxy terminus of human Smac. Nature Synthetic Expression System N/A Species Reactivity Mouse, rat, human Conjugate Unconjugated Applications Used as a blocking peptide in immunoblotting applications. Procedure None Format Liquid Concentration 200 μg/mL Size 0.05mg Preservative None Storage -20°C ANTIGEN GENE INFORMATION Gene Name DIABLO diablo, IAP-binding mitochondrial protein [ Homo sapiens (human) ] Official Symbol DIABLO Synonyms DIABLO; diablo, IAP-binding mitochondrial protein; SMAC; DFNA64; diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved caspase Entrez Gene ID 56616 mRNA Refseq NM_001278302 Protein Refseq NP_001265231 UniProt ID Q9NR28 Pathway Apoptosis; Apoptosis Modulation and Signaling; Apoptotic factor-mediated response; Caspase cascade in apoptosis; Intrinsic Pathway for Apoptosis; Release of apoptotic factors from the mitochondria; SMAC binds to IAPs; SMAC-mediated apoptotic response Function protein binding 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.