SunLong Biotech Co.,LTD Tel: 0086-571- 56623320 Fax:0086-571- 56623318 E-mail:[email protected] www.sunlongbiotech.com Rabbit Anti-Ubiquitously expressed transcript/FITC Conjugated antibody SL6749R-FITC Product Name: Anti-Ubiquitously expressed transcript/FITC Chinese Name: FITC标记的广泛表达转录蛋白UXT抗体 Androgen receptor trapped clone 27 protein; ART 27; Protein UXT; Ubiquitously Alias: expressed transcript; Ubiquitously expressed transcript protein; UXT_HUMAN. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep, IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 18kDa Form: Lyophilized or Liquid Concentration: 1mg/ml KLH conjugated synthetic peptide derived from human UXT/Ubiquitously expressed immunogen: transcript Lsotype: IgGwww.sunlongbiotech.com Purification: affinity purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: UXT is a novel protein, highly conserved in mouse. It interacts with the N terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional Product Detail: activation. It is abundantly expressed in tumor tissues and is likely to be involved in tumorigenesis. Function: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Subunit: Homohexamer. Interacts with LRPPRC. Interacts with AR N-terminus. In the nucleus interacts specifically with RELA and forms a dynamic complex with NF-kappa-B and is recruited to the NF-kappa-B enhanceosome upon stimulation. Interacts with MECOM and URI1. Tissue Specificity: Ubiquitous. Expressed in prostate epithelial cells. Overexpressed in a number of tumor tissues (PubMed:16221885). Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest levels in bladder and uterus. Similarity: Belongs to the UXT family. Database links: Entrezwww.sunlongbiotech.com Gene: 525680Cow Entrez Gene: 480900Dog Entrez Gene: 8409Human Entrez Gene: 22294Mouse Entrez Gene: 299313Rat Omim: 300234Human SwissProt: Q32P97Cow SwissProt: Q9UBK9Human SwissProt: Q9WTZ0Mouse SwissProt: Q63ZY7Rat Unigene: 172791Human Unigene: 735566Human Unigene: 34779Mouse Unigene: 203381Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. www.sunlongbiotech.com.