1 Welcome On behalf of the ECCB’14 Organizing and Steering Committees we are very happy to welcome you to Strasbourg, Heart of Europe. We hope that you will enjoy the many facets of the conference: keynote lectures, oral communications, workshops and tutorials, demos, posters, booths. This dense and attractive program is intended to be the substrate of fruitful discussions and networking among all of you. We are proud to welcome seven distinguished Keynote Speakers: Nobel Prize laureate Jean-Marie Lehn (Strasbourg University, Nobel Prize in Chemistry in 1987), Patrick Aloy (Institute for Research in Biomedicine, Barcelona, Spain), Alice McHardy (Heinrich Heine University, Düsseldorf and Helmholtz Center for Infection Biology, Braunschweig, Germany), Nada Lavrač (Jožef Stefan Institute and University of Nova Gorica, Slovenia), Ewan Birney (European Bioinformatics Institute, Hinxton, United Kingdom), Doron Lancet (The Weizmann Institute of Science, Rehovot, Israel) and Eric Westhof (Strasbourg University, France). A large variety of Workshops, Tutorials and Satellite Meetings will take place on Saturday, September 6 and Sunday, September 7 to kick off the conference! We would like to stress the interest in the conference by the Council of Europe, whose headquarters are in Strasbourg. An invited talk by Laurence Lwoff, Head of the Bioethics Unit, is scheduled during the opening ceremony, in which she will share the Council of Europe’s concerns about the bio-ethical challenges raised by the usage of biobanks and biomedical data in research and its applications. The Council of Europe will also host the Gala Evening on Tuesday in its nice reception hall and gardens along the Ill river. Great thanks are due to all people who made ECCB’14 happen, including the ISCB and our commercial and academic sponsors who allowed us to distribute 67 travel fellowships for early-stage scientists. Thank you all for being there: each of you will bring something to the conference! We wish you an enjoyable ECCB’14 in Strasbourg! Marie-Dominique Devignes and Yves Moreau Conference chair and co-chair 2 3 Table of Contents Welcome .............................................................................................................................................................................. 1 Table of Contents .............................................................................................................................................................. 4 Map ...................................................................................................................................................................................... 5 Public Transport and Site Seeing ................................................................................................................................. 6 Floor Plan ............................................................................................................................................................................ 7 Organization ...................................................................................................................................................................... 8 Sponsors and Exhibitors ............................................................................................................................................... 12 Keynotes ............................................................................................................................................................................ 16 Schedule ............................................................................................................................................................................ 20 Workshops ........................................................................................................................................................................ 26 Tutorials ............................................................................................................................................................................ 37 Satellite Meeting ............................................................................................................................................................. 43 Oral Presentations .......................................................................................................................................................... 44 Industrial and Academic Demos ................................................................................................................................ 66 Posters ................................................................................................................................................................................ 72 Social events .................................................................................................................................................................... 91 Science Web Art: Banner Contest (Voting Instructions) ................................................................................. 92 4 Map 5 Public Transport and Site Seeing Pass 3-days for tramway and bus Every participant has received a 3-day pass for Strasbourg public transport. You can consult Strasbourg Public Transport maps on-line on http://www.cts-strasbourg.eu/en/ Itineraries 1. To reach the Forum at the Faculté de Médecine - by bus : take line 10, stop at "Hotel du département". - by tramway : stop at "Musée d'Art Moderne", take the bridge, cross the road and turn left. Then follow the ECCB signs on the road 2. To reach the PMC (Palais de la Musique et des Congrès - Convention Centre) - by tramway line B or C, stop at "Wacken". Then follow the ECCB signs on the road 3. Gala evening at the Council of Europe The Gala at the Council of Europe includes a boat trip and the dinner at the Council. In your congress bag, you will find a boat ticket with a departure time: PLEASE RESPECT THE DEPARTURE TIME WRITTEN ON YOUR TICKET. The boat will take you to the Council of Europe after a small trip around Strasbourg. The boat pier is located 150 m from the Cathedral: having the cathedral in front of you, go to the right (rue du Maroquin) down to the river. (See also map p10). Information on batorama http://www.batorama.com/ In case you want to go to the Council of Europe by your own, take bus line 6 stop at "Conseil de l'Europe" or tramway line E stop at "Droits de l'Homme". 4. Gala evening at the Ancienne Douane The Gala at the Ancienne Douane includes a mini-train trip and the dinner at a famous typical Alsacian restaurant. In the congress bag you received when registering, you will find a mini-train ticket with departure time that will take you for a small visit trip around Strasbourg: PLEASE RESPECT DEPARTURE TIME WRITTEN ON YOUR TICKET. The mini-train station is located "place Gutemberg", in front of the Cathedrale (See also map p10). Information on mini-train http://www.cts-strasbourg.eu/en/getting- around/tourism/ Site Seeing in Strasbourg and Nancy 1. Strasbourg Tourism Office: 17 place de la Cathédrale, Strasbourg ; Tél. +33 (0)3 88 52 28 28 http://www.otstrasbourg.fr/en/ 2. Nancy Tourism Office: Place Stanislas, Nancy ; Tel. +33 (0)3 83 35 22 41 http://en.nancy- tourisme.fr/ Nancy is 90 min away from Strasbourg by train. 6 Floor Plan Palais de la Musique et des Congrès (PMC) : Main Floor Palais de la Musique et des Congrès (PMC) : 1st Floor 7 Organization Conference Chairs Marie-Dominique Devignes, CNRS-University of Lorraine, Nancy, France Yves Moreau, University of Leuven, Belgium Local Organizing committee Mario Albrecht, Graz University of Technology, Austria Francisco Azuaje, CRP-Santé, Luxembourg Adrien Coulet, University of Lorraine, Nancy, France Manuel Dauchez, University of Reims, France Sophie Schbath, INRA, Jouy-en-Josas, France Thomas Lengauer, Max Planck Institute for Informatics, Saarbrücken, Germany Hans-Peter Lenhof, Center for Bioinformatics, Saarland University, Germany Magali Michaut, Netherlands Cancer Institute, Amsterdam, The Netherlands Emmanuelle Morin, INRA, Nancy – Champenoux, France Luc Moulinier, CNRS, Strasbourg, France Olivier Poch, CNRS, Strasbourg, France Dave Ritchie, Inria Nancy-Grand Est, France Marie-France Sagot, Inria Grenoble Rhône-Alpes, Lyon, France Malika Smaïl-Tabbone, University of Lorraine, Nancy, France Julie Thompson, CNRS, Strasbourg, France ECCB Steering Committee Ron Appel, Swiss Institute of Bioinformatics, Switzerland Søren Brunak, Technical University of Denmark and University of Copenhagen, Denmark Jaap Heringa, Vrije Universiteit, Amsterdam, The Netherlands Oliver Kohlbacher, University of Tübingen, Germany Michal Linial, The Hebrew University of Jerusalem, Israel Rodrigo Lopez, European Bioinformatics Institute, Hinxton, United Kingdom Yves Moreau, University of Leuven, Belgium Marie-France Sagot, Inria Grenoble Rhône-Alpes, Lyon, France Torsten Schwede, SIB and Biozentrum, University of Basel, Switzerland Anna Tramontano (chair), University of Rome "La Sapienza", Italy Alfonso Valencia, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain Jaak Vilo, University of Tartu, Estonia Martin Vingron, Max Planck Institute for Molecular Genetics, Berlin, Germany Janet Thornton, European Bioinformatics Institute, Hinxton, United Kingdom Program Committee – Area Chairs A. Sequencing and sequence analysis for genomics Cedric Notredame, Centre for Genomic Regulation, Barcelona, Spain Eric Rivals, Laboratory of Informatics, Robotics and