Name Aliases Binding partner Physiology / Oncology References AJAP1 Adherens junction associated protein 1, ? PHY : Expressed in uterus and pancreas. [1] http://www.uniprot.org/uniprot/Q9UKB5. [2] SHREW1 Plays a role in cell adhesion and migration. McDonald JM, Cancer Biol Ther 2006, 5:300-4 Forms a complex with CDH1 and beta-catenin at adherens junctions [1] ONC : Frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration [2] ALCAM Activated leukocyte cell adhesion CD6 PHY : Adhesion of activated leukocytes and [1] Ofori-Acquah SF, Transl Res 2008, 151:122- molecule, CD166, MEMD (melanoma neurons 8. [2] van Kilsdonk JW, Cancer Res 2008, metastasis clone D) 68:3671-9 ONC : Expressed by different tumor types including melanoma; mediates cancer/ melanoma invasiveness [1,2] AMICA1 Adhesion molecule interacting with CXADR PHY : Expression is restricted to the [1] http://www.uniprot.org/uniprot/Q86YT9. [2] CXADR antigen 1, JAML (junctional hematopoietic tissues with the exception of Moog-Lutz C, Blood 2003, 102:3371-8 adhesion molecule-like) liver. May function in transmigration of leukocytes through epithelial and endothelial tissues. Mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells [1] ONC : Enhances myeloid leukemia cell adhesion to endothelial cells [2] AMIGO1 Amphoterin-induced gene and open AMIGO PHY : May be involved in fasciculation as well [1] http://www.uniprot.org/uniprot/Q86WK6 reading frame 1, Alivin-2 as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain [1] ONC : - AMIGO2 Amphoterin-induced gene and open AMIGO PHY : Highest levels in breast, ovary, cervix, [1] http://www.uniprot.org/uniprot/Q86SJ2. [2] reading frame 2, DEGA (Differentially and uterus. May mediate homophilic as well Rabenau KE, Oncogene 2004, 23:5056-67 expressed in gastric adenocarcinomas) as heterophilic cell-cell interaction with MMMP Biomap #87 Page 1 AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain [1] ONC : High expression in 45% of gastric adenocarcinomas; stable expression of an antisense construct in a gastric adenocarcinoma cell line leads to increased ploidy, chromosomal instability, decreased cell adhesion/ migration and nearly complete abrogation of tumorigenicity in nude mice [2] AMIGO3 Amphoterin-induced gene and open AMIGO PHY : May mediate heterophilic cell-cell [1] http://www.uniprot.org/uniprot/Q86WK7 reading frame 3 interaction. May contribute to signal transduction through its intracellular domain [1] ONC : - BCAM Basal cell adhesion molecule, CD239, Laminins (?) PHY : Associated with basal layer of epithelial [1] Kikkawa Y, Exp Cell Res 2008, 314:2579-90 Lutheran blood group antigen and endothelial cells ONC : Mediates adhesion of hepatocellular carcinoma (HCC) cells to laminin alpha 5 [1] CADM1 Cell adhesion molecule 1, TSLC1 (tumor CADM1 PHY : Calcium-independent homophilic and [1] Murakami Y, Cancer Sci 2005, 96:543-52. [2] suppressor in lung cancer), IGSF4, CADM3 heterophilic cell-cell adhesion Nowacki S, Oncogene 2008, 27:3329-38. [3] SYNCAM1 PVRL3 Kikuchi S, Cancer 2006, 106:1751-8 ONC : Considered a tumor suppressor gene [1], especially for neuroblastoma [2] and lung cancer [3] CADM2 Cell adhesion molecule 2, NECL3, ? PHY : ? [1] http://www.uniprot.org/uniprot/Q8N3J6 SYNCAM2 ONC : - CADM3 Cell adhesion molecule 3, IGSF4B, CADM3 PHY : Calcium-independent homophilic and [1] Fukuhara H, Oncogene 2001, 20:5401-7 TSLL1 (TSLC1-like 1), NECL1, IGSF4 heterophilic cell-cell adhesion activity SYNCAM3 PVRL1 PVRL3 ONC : Possibly involved in cancer biology (CADM1 homologous) [1] CADM4 Cell adhesion molecule 4, IGSF4C, ? PHY : Calcium- and magnesium-independent [1] Fukuhara H, Oncogene 2001, 20:5401-7 TSLL2 (TSLC1-like 2), NECL4, cell-cell adhesion activity SYNCAM4 ONC : Possibly involved in cancer biology MMMP Biomap #87 Page 2 (CADM1 homologous) [1] CD2 CD2 antigen p50, LFA-2, LFA-3 receptor, LFA-3 PHY : CD2 interacts with lymphocyte function- [1] http://www.uniprot.org/uniprot/P06729. [2] rosette receptor, T-cell surface antigen CD48 associated antigen (LFA-3) and CD48 to Perea G, Leuk Res 2005, 29:1109-16 T11/Leu-5 mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function ONC : CD2 (and CD36) expression has an adverse prognostic impact in adult de novo acute myeloid leukemia (AML) patients [2] CD4 CD4 antigen p55, T-cell surface antigen MHC class II PHY : Identifies helper T cells (HTL) and [1] http://www.uniprot.org/uniprot/P01730 T4/Leu-3 suppressor/ regulatory T cells (Treg) that interact with MHC class II bearing targets. Singaling and adhesion coreceptor in class II restricted antigen-induced T cell activation. Primary receptor for HIV virus [1] ONC : - CD6 Tp120 CD166 PHY : Expressed by thymocytes, mature T- [1] http://www.uniprot.org/uniprot/P30203 cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. After T-cell activation, becomes phosphorylated on Ser, Thr and Tyr residues [1] ONC : - CD8a CD8 alpha (p32), T-lymphocyte MHC class I PHY : Identifies cytotoxic T cells (CTL) and [1] Smith TR, Trends Immunol 2008, 29:337-42. differentiation antigen T8/Leu-2 suppressor/ regulatory T cells (Treg) that [2] http://www.uniprot.org/uniprot/P01732 interact with MHC class I bearing targets. Signaling and adhesion coreceptor in class II restricted antigen-induced T cell activation. In general heterodimer of an alpha and a beta chain [2] ONC : - CD8b CD8 beta (p37), T-cell surface MHC class I PHY : Identifies cytotoxic T cells (CTL) and [1] Smith TR, Trends Immunol 2008, 29:337-42. glycoprotein CD8 beta chain suppressor/ regulatory T cells (Treg) that [2] http://www.uniprot.org/uniprot/P10966 interact with MHC class I bearing targets. Signaling and adhesion coreceptor in class II restricted antigen-induced T cell activation. In general heterodimer of an alpha and a beta MMMP Biomap #87 Page 3 chain [2] ONC : - CD9 Tetraspanin-29, Leukocyte antigen MIC3 ? PHY : Involved in platelet activation and [1] http://www.uniprot.org/uniprot/P21926. [2] aggregation. Regulates paranodal junction Ikeyama S, J Exp Med 1993, 177:1231-7. [3] formation. Required for gamete fusion. Miyake M, Oncogene 2000, 19:5221-6. [4] Involved in cell adhesion and motility. Nakazawa Y, Blood 2008, 112:1730-9. [5] De Bruyne E, Clin Cancer Res 2008, 14:2918-26. Expressed by a variety of hematopoietic and [6] Longo N, Blood 2001, 98:3717-26. [7] Hong epithelial cells [1]. CD9 (and CD81) associate IK, Exp Mol Med 2005, 37:230-9. [8] Hemler with phosphatidyl inositol 4-kinase (PI4K), ME, Nat Rev Mol Cell Biol 2005, 6:801-11 which locally produces phosphoinositides (such as phosphatidylinositol-4,5- bisphosphate; this causes the recruitment and activation of SHC (SRC-homology-2-domain- containing transforming protein): subsequent RAS-mediated activation of ERK or p38MAPK or JNK pathways leads to proliferation or apoptosis, respectively [8] ONC : Suppresses cell motility and in vivo metastasis of mouse melanoma [2,3]. CD9 may act as a metastasis suppressor, at least in part, by neutralizing Aggrus-mediated platelet aggregation [4]. In multiple myeloma, CD9 is epigenetically silenced during disease progression and correlates with survival [5]. However, anti-CD9 antibodies inhibit transendothelial migration of melanoma cells [6]; plus, CD9 induces MMP-2 expression by activating c- Jun through p38 MAPK and JNK signaling pathways in human melanoma cells [7] CD33 CD33 antigen (gp67), SIGLEC3 (Sialic Sialic acid containing PHY : Putative adhesion molecule of [1] http://www.uniprot.org/uniprot/P20138. [2] acid-binding Ig-like lectin 3), sialoadhesin proteins myelomonocytic-derived cells that mediates Stasi R, Expert Opin Biol Ther 2008, 8:527-40 sialic-acid dependent binding to cells. Contains 2 copies of a cytoplasmic immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. In the immune response, may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation MMMP Biomap #87 Page 4 by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules [1] ONC : Is used as a therapeutic target for acute myeloid leukemia [2] CD34 - L-selectin PHY: Adhesion molecule with a role in early [1] http://www.uniprot.org/uniprot/P28906 hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues [1] ONC : - CD36 GP3B, PAS-4, Platelet collagen receptor, Collagen PHY : Expressed by platelets, macrophages [1] http://www.uniprot.org/uniprot/P16671. [2] Thrombospondin receptor, Fatty acid Thrombospondin and microvascular endothelial cells. McCarty MF, Med Hypotheses 2008, 70:419-23 translocase Scavenger receptor for oxidized LDL. Platelet adhesion. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Defects in CD36 are the cause of platelet glycoprotein IV deficiency [1] ONC : The ability of metronomic chemotherapy to induce endothelial apoptosis