BAYER AND TEMPUS Genomic Cancer Testing Program Your Tumor's DNA / RNA Can Help Identify the Best Treatment Option(s) Available Genomic cancer testing, sometimes referred to as biomarker testing, helps detect changes in a tumor’s DNA—called genomic alterations—that can affect how your cancer grows and spreads. The results of the test can help your doctor create a treatment plan. Talk to Your Doctor About Genomic Cancer Testing The only way to identify genomic alterations is with genomic cancer testing. This test can reveal information about what may be driving the growth of your colorectal cancer (CRC), such as an NTRK gene fusion. NTRK Gene Fusions and Colorectal Cancer Cancer may contain an actionable alteration, which is a genomic alteration that NTRK Gene and Unrelated Gene your doctor can act on with approved treatment(s) or a drug(s) in a clinical trial. One of the actionable alterations included in the test is an NTRK gene fusion. NTRK gene fusions can be found in cancers that form in many parts of the body, NTRK and including the colon. When an NTRK gene joins—or fuses—with a different, Unrelated Genes Break and Join unrelated gene, it can cause cancer cells to multiply. Some patients with metastatic colorectal cancer exhibit MicroSatellite Instability (MSI). High MSI (MSI-H) results from defects in the way cells repair NTRK Gene Fusion their DNA as they divide. NTRK gene fusions are more prevalent among MSI-H CRC cases Studies suggest NTRK gene fusions are found in a range of 0.2% to 2.7% of all colorectal cancer cases and in approximately 5% of MSI-H CRC cases. Bayer is Sponsoring a Genomic Cancer Test (Tempus xT) for Eligible CRC Patients at NO COST Bayer is collaborating with Tempus in offering Tempus xT, a broad genomic test that detects actionable alterations, including NTRK gene fusions, for eligible mCRC patients with confirmed MSI-H status. Bayer will cover the cost of the xT test regardless of the results, treatment decision or insurance coverage Just Three Easy Steps to Enroll Download the Test Speak with your doctor Based on the results, your Requisition Form at and request to get tested at doctor will discuss appropriate Tempus.com/bayerprogram NO COST if you are eligible treatment options with you © 2020 Bayer. All rights reserved. Bayer and the Bayer Cross are registered trademarks of Bayer. 12/2020 | PP-PF-ONC-US-1610-1 Learn more… How do I know if I have MSI-H mCRC? Why should I consider a genomic cancer test? If you have been diagnosed with metastatic colorectal cancer Genomic cancer testing is the best method to uncover actionable (mCRC), talk to your doctor to find out if you have high alterations in your tumor, which means that they could be microsatellite instability (MSI-H). matched to either an approved therapy or a drug in a clinical trial. Ask your doctor about eligibility and whether a genomic cancer test may be right for you or a loved one. What is the difference between genetic testing and genomic cancer testing? Genomic cancer testing helps identify what may be driving your tumor to grow and spread by looking at your entire genome. By contrast, genetic testing looks at inherited traits or disease risks that may be passed down from generation to generation based on a specific set of genes and typically involves genetic counseling. CANCER TESTING ABOUT GENOMIC Am I eligible for the testing program? Any U.S. metastatic colorectal cancer (mCRC) patient with high microsatellite instability (MSI-H) and a previously biopsied tumor is eligible to enroll in the program. Patients who have not previously undergone a biopsy may still enroll in the program but should work with their doctor to collect the tumor sample and cover associated costs. This program ONLY covers the full cost of the Tempus xT test. Is this relevant for me if I am already receiving treatment? Yes, genomic cancer testing is still relevant because understanding your tumor's genomic profile may inform your doctor of alternate or future treatment options. You should discuss next steps with your doctor. Who should I contact to participate in this program? Please talk to your doctor to learn more about your eligibility to receive a genomic cancer test at NO COST. What if I don’t have health insurance? Will I be financially responsible for this? Any mCRC patient with MSI-H is eligible to participate in the program regardless of insurance coverage. There will be NO COST for the Tempus xT test under this program. ABOUT THE BAYER AND TEMPUS ENOMIC CANCER TESTING PROGRAM G How long will it take to get my results? Once your doctor submits your tumor sample and registration form to Tempus, your doctor will receive the results within 14 days. ABOUT My doctor submitted the test and received the report. Now what? Meet with your doctor to discuss the potential treatment options based on the test results. NEXT STEPS © 2020 Bayer. All rights reserved. Bayer and the Bayer Cross are registered trademarks of Bayer. 12/2020 | PP-PF-ONC-US-1610-1.