Supplementary Table 6: Hypothalamic ARC microarray fold changes between DR and Chow mice. Genes increased in DR compared to Chow (in order of fold change) Fold Gene Gene name change P-value Cga glycoprotein hormones, alpha subunit 2.629 0.017 BC038167 1.734 0.019 Gng2 guanine nucleotide binding protein (G protein), gamma 2 1.596 0.007 Ecel1 endothelin converting enzyme-like 1 1.577 0.024 Inmt indolethylamine N-methyltransferase 1.572 0.047 Rsph1 radial spoke head 1 homolog (Chlamydomonas) 1.544 0.015 Npffr1 PREDICTED: neuropeptide FF receptor 1 1.536 0.019 Apoc3 apolipoprotein C-III 1.502 0.023 Mrpl9 mitochondrial ribosomal protein L9 1.500 0.042 Genes decreased in DR compared to Chow (in order of fold change) Ankrd11 ankyrin repeat domain 11 -2.826 0.003 Pkp4 plakophilin 4 (Pkp4) -2.50978 0.009 B230209E15Rik PREDICTED: RIKEN cDNA B230209E15 gene -2.25316 0.007 Eif5 eukaryotic translation initiation factor 5 -2.15052 0.040 Gcap14 granule cell antiserum positive 14 -2.14545 0.016 Cplx2 complexin 2 -2.12784 0.019 eukaryotic translation initiation factor 4E binding protein Eif4ebp2 2 -2.1111 0.008 scl0002315.1_12 -2.10515 0.022 Sept03 septin 3 -2.08598 0.044 4921506J03Rik -2.03777 0.012 5730455P16Rik RIKEN cDNA 5730455P16 gene -1.9862 0.028 3300001P08Rik RIKEN cDNA 3300001P08 gene -1.98069 0.031 6430548M08Rik -1.97259 0.021 Peg3 paternally expressed 3 -1.96637 0.008 Atxn1 ataxin 1 -1.96061 0.019 Lin7a lin-7 homolog A (C. elegans) -1.95696 0.015 Scn1a -1.90695 0.028 Zmat1 zinc finger, matrin type 1 -1.90296 0.008 Tbl1x transducin (beta)-like 1 X-linked -1.90109 0.006 Cntn2 contactin 2 -1.89999 0.014 Zeb2 zinc finger E-box binding homeobox 2 -1.89491 0.009 Impad1 inositol monophosphatase domain containing 1 -1.88478 0.008 Csnk2a1-rs3 -1.86782 0.020 Rgs7bp regulator of G-protein signalling 7 binding protein -1.85758 0.009 DNA segment, Chr 11, Brigham & Women's Genetics 0517 D11Bwg0517e expressed -1.83038 0.025 ELAV (embryonic lethal, abnormal vision, Drosophila)-like Elavl3 3 (Hu antigen C) -1.81927 0.0009 Osbpl1a oxysterol binding protein-like 1A -1.81829 0.0040 N-ethylmaleimide sensitive fusion protein attachment Napb protein beta -1.80157 0.018 Clic4 chloride intracellular channel 4 (mitochondrial) -1.78587 0.002 Limch1 LIM and calponin homology domains 1 -1.77659 0.003 Fbxo41 F-box protein 41 -1.77105 0.004 Hist1h2ak histone cluster 1, H2ak -1.75258 0.029 Myoc myocilin -1.75234 0.006 Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 -1.74423 0.014 Mtap9 microtubule-associated protein 9. -1.73725 0.008 Alcam activated leukocyte cell adhesion molecule -1.73406 0.036 B930006L02Rik -1.73299 0.002 C030033M19Rik -1.72995 0.010 Fam168a family with sequence similarity 168, member A -1.72689 0.003 Pabpc1 poly A binding protein, cytoplasmic 1 -1.72379 0.001 1110001C20Rik -1.7224 0.019 Nrp1 neuropilin 1 -1.71975 0.014 Klf7 Kruppel-like factor 7 (ubiquitous) -1.70925 0.032 Pcdh9 protocadherin 9 -1.70637 0.012 BC042720 PREDICTED: cDNA sequence BC042720 -1.70327 0.004 Susd4 sushi domain containing 4 -1.70091 0.023 Fbxl11 F-box and leucine-rich repeat protein 11 -1.69822 0.010 Ankrd12 ankyrin repeat domain 12 -1.68516 0.006 Fam134b family with sequence similarity 134, member B -1.67611 0.029 Scn3a sodium channel, voltage-gated, type III, alpha -1.67477 0.022 Mboat2 membrane bound O-acyltransferase domain containing 2 -1.67127 0.020 Mpv17 Mpv17 transgene, kidney disease mutant -1.67012 0.019 Arid4a AT rich interactive domain 4A (RBP1-like) -1.66886 0.016 Cygb cytoglobin -1.66305 0.029 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X- Ddx3x linked -1.65898 0.010 Mapk8ip2 -1.65183 0.007 Synm synemin, intermediate filament protein -1.65168 0.011 Nfic nuclear factor I/C -1.63259 0.020 Csnk1e casein kinase 1, epsilon -1.60503 0.048 proteasome (prosome, macropain) 26S subunit, non- Psmd1 ATPase, 1 -1.60227 0.008 LOC671878 PREDICTED: similar to spermine synthase -1.60084 0.021 PREDICTED: similar to neurotrophic tyrosine kinase, LOC100047606 receptor, type 3 -1.60083 0.011 Dusp1 dual specificity phosphatase 1 -1.59973 0.011 Map3k1 mitogen-activated protein kinase kinase kinase 1 -1.59181 0.004 Zfp326 zinc finger protein 326 -1.59108 0.013 Odz2 odd Oz/ten-m homolog 2 (Drosophila) -1.58915 0.013 A930010C08Rik -1.58678 0.026 C130072A16Rik -1.58537 0.009 Cnnm1 cyclin M1 -1.57887 0.011 Hnt neurotrimin -1.57729 0.014 Zc3h13 zinc finger CCCH type containing 13 -1.57357 0.004 D030034I04Rik -1.56794 0.026 Brunol4 bruno-like 4, RNA binding protein (Drosophila) -1.56604 0.045 Aqp4 aquaporin 4 -1.56564 0.039 Unc13c unc-13 homolog C (C. elegans) -1.56237 0.017 Nr4a2 nuclear receptor subfamily 4, group A, member 2 -1.56084 0.025 Keap1 kelch-like ECH-associated protein 1 -1.5581 0.011 scl0001493.1_2 -1.55692 0.041 Dpysl3 dihydropyrimidinase-like 3 -1.55663 0.020 Exoc4 exocyst complex component 4 -1.55518 0.049 Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 -1.54355 0.029 Sfrs15 splicing factor, arginine/serine-rich 15 -1.54271 0.0008 Pcyt1a phosphate cytidylyltransferase 1, choline, alpha isoform -1.54127 0.012 Rnf6 ring finger protein (C3H2C3 type) 6 -1.53589 0.010 Tshz1 teashirt zinc finger family member 1 -1.5351 0.013 Pdap1 PDGFA associated protein 1 -1.53417 0.010 PREDICTED: similar to Limb expression 1 homolog LOC100045869 (chicken) -1.53324 0.003 protein tyrosine phosphatase, receptor type Z, Ptprz1 polypeptide 1 -1.53222 0.001 peroxisome proliferative activated receptor, gamma, Ppargc1a coactivator 1 alpha -1.52998 0.014 2900083I11Rik -1.52907 0.003 4732418C07Rik RIKEN cDNA 4732418C07 gene -1.52385 0.017 E430005I09Rik -1.52259 0.016 Gnaq guanine nucleotide binding protein, alpha q polypeptide -1.52151 0.035 Zswim6 -1.52027 0.039 2600009P04Rik -1.51949 0.011 Dusp7 dual specificity phosphatase 7 -1.51903 0.006 Sel1l sel-1 suppressor of lin-12-like (C. elegans) -1.51711 0.014 4732462B05Rik -1.51482 0.016 C030011O14Rik -1.50903 0.013 Elfn2 leucine rich repeat and fibronectin type III, extracellular 2 -1.50901 0.048 Ddx26 -1.50695 4.04E-06 PREDICTED: Mus zinc finger protein 292, transcript Zfp292 variant 4 -1.50451 0.022 C130078N17Rik -1.50225 0.005 .