USO08080371B2 (12) United States Patent (10) Patent No.: US 8,080,371 B2 Ballinger et al. (45) Date of Patent: Dec. 20, 2011 (54) MARKERS FOR ADDICTION FOREIGN PATENT DOCUMENTS WO WO92fO2638 * 2/1992 (75) Inventors: Dennis Ballinger, Menlo Park, CA (US); Karel Konvicka, San Francisco, OTHER PUBLICATIONS CA (US); Laura Jean Bierut, St. Louis, MO (US); John Rice, St. Louis, MO Langdahl, Bente et al. Osteoporotic fractures are assoicated with an (US); Frank Scott Saccone, St. Louis, 86 base pair repeat polymoprhism in the interleukin 1 receptor MO (US); Anthony L. Hinrichs, St. antagonist gene but not with polymoprhisms in the interleukin 1B Louis, MO (US); Alison M. Goate, St. gene. 2000. Journal of Bone and Mineral Research. vol. 15 No. 3 pp. Louis, MO (US); Jen Wang, Ballwin, 402-414. MO (US) Wall, Jeffery et al. Haplotype blocks and linkage disequilbirium in the human genome. 2003. Nature Reviews Genetics. vol. 4 pp. 587 (73) Assignee: The Washington University, St. Louis, 597.* MO (US) Arnhelm, N., et al., C&EN 36-47 (1990).* Barrett J.C., et al., Bioinformatics 21(2):263-265 (2005).* (*) Notice: Subject to any disclaimer, the term of this Barringer, K.J., et al., Gene 89:117-122 (1990).* patent is extended or adjusted under 35 Beaucage, S.L., et al., Tetrahedron Letts.–22(20): 1859-1862 U.S.C. 154(b) by 18 days. (1981).* Becker, J., et al., Mol Gen Genet 249:65-73 (1995).* (21) Appl. No.: 11/681,177 Benjamini, Y., et al., J.R. Stat. Soc. B–57(1):289-300 (1995). Beuten, J., et al., Am. J. Hum. Genet. 76:859-864 (2005). (22) Filed: Mar. 1, 2007 Beuten, J., et al., Am. J. Med. Genet. B Neuropsychiatr. Genet.— 139:73-80 (2005). (65) Prior Publication Data Bierut, L.J. et al., Hum. Mot. Genet.—16(1):24-35 (2007). US 2007/O258898A1 Nov. 8, 2007 Bierut, L.J., et al., Am. J. Med. Genet.—124A:19-27 (2004). Bierut, L.J., et al., Arch. Gen. Psychiatry -55:982–988 (1998). Related U.S. Application Data Blok, H.J., et al., Mol Cell Probes–11:187-194 (1997). Bonnet, G., et al., Proc. Natl. Acad. Sci. U.S.A.–96:6171-6176 (60) Provisional application No. 60/778,597, filed on Mar. (1999). 1, 2006, provisional application No. 60/811,318, filed Boustead. C. et al., Pharmacogenetics—7:411-414 (1997). on Jun. 6, 2006. Breslau, N., et al., Psychol. Med. 34:323-333 (2004). Breslau, N., et al., Biol. Psychiatry–55:69-76 (2004). (51) Int. Cl. Breslau, N., et al., Am. J. Public Health 90:1122-1127 (2000). CI2O I/68 (2006.01) Busby, V., et al., Neuromolecular Med—5:133-146 (2004). CI2P 19/34 (2006.01) Butt, C.M., et al. Alcohol. Clin. Exp. Res. 27(5):733-742 (2003). C7H 2L/04 (2006.01) Butt, C.M., et al., Behav Neurosci-119(1):26-37 (2005). (52) U.S. Cl. ........ 435/6; 435/91.2:536/24.33: 536/23.1 CDC (2005) Annual smoking-attributable mortality, years of poten (58) Field of Classification Search ........................ None tial life lost, and productivity losses United States, 1997-2001— See application file for complete search history. Morbidity & Mortality Weekly Report 54.625-628. CDC (2005) Cigarette Smoking among adults United States, (56) References Cited 2004 Morbidity & Mortality Weekly Report–54:121-1124. CDC (2004) Cigarette use among high school students United U.S. PATENT DOCUMENTS States, 1991-2003 Morbidity & Mortality Weekly Report 53:499 4,683.202 A * 7/1987 Mullis 5O2. 5,045,694. A * 9, 1991 Beavis et al. Carlson, C.S., et al., Am. J. Hum. Genet. 74: 106-120 (2004). 5,202,561 A * 4, 1993 Giessmann et al. 5,468,613 A * 1 1/1995 Erlich et al. (Continued) 5,925,517 A * 7/1999 Tyagi et al. 6,037,130 A * 3/2000 Tyagi et al. 6,111.251 A * 8/2000 Hillenkamp Primary Examiner — Amanda Shaw 6,150,097 A * 1 1/2000 Tyagi et al. 6,174,670 B1* 1/2001 Wittwer et al. 6,342,355 B1* 1/2002 Hacia et al. 6,740,510 B2 * 5, 2004 Kautzer et al. (57) ABSTRACT 6,897,025 B2* 5/2005 Cox et al. 6,898,531 B2* 5/2005 Sheehan et al. Correlations between polymorphisms and addiction are pro 6,969,589 B2 * 1 1/2005 Patilet al. vided. Methods of diagnosing, prognosing, and treating 7,127,355 B2 * 10/2006 Cox et al. 2003. O108919 A1* 6, 2003 Kautzer et al. addiction are provided. Systems and kits for diagnosis, prog 2004/OO23237 A1* 2, 2004 Patil et al. nosis and treatment of addiction are provided. Methods of 2004/0229224 A1* 11, 2004 Frazer et al. identifying addiction modulators are also described. 2004/0241657 A1* 12, 2004 Patil et al. 2005.0003410 A1* 1/2005 Frazer et al. 2005/OOO7375 A1* 1/2005 Y 2005, OO19787 A1* 1/2005 Berno et al. 6 Claims, 27 Drawing Sheets 2006,0166224 A1* 7, 2006 Norvel (10 of 27 Drawing Sheet(s) Filed in Color) US 8,080,371 B2 Page 2 OTHER PUBLICATIONS Liu, Q.R. et al., Proc. Natl. Acad. Sci. U. S. A.—102: 11864-11869 (2005). Carmelli, D., et al., N. Engl. J. Med. 327(12):829-833 (1992) Lockhart, D.J., Nature Medicine 4:1235-1236 (1998). Abstract Only. Lomell, H., et al., J. Clin. Chem.–35:1826-1831 (1989). Chee, M., et al., Science 274:610-614 (1996). Lowry, O. H., et al. J. Biol. Chem.–193:265-275 (1951). Cheng, S., et al., Nature 369:684-685 (1994). Ma, J.Z., et al., Hum. Mol. Genet.–14(12): 1691-1698 (2005). Cholerton, S., et al., Pharmacogenetics—6:261-263 (1996). Madden, P.A., et al., Behav. Genet. 29(6):423-431 (1999). Comings, D.E., et al., Pharmacogenetics—6:73-79(1996). Marks, M. J., et al., J. Pharmacol. Exp. Ther. 285(1):377-386 Corrigall, W.A., et al., Brain. Res. 653:278-284 (1994). (1998). Craig, A.M., et al., Trends Neurosci...—29:8-20 (2006). Marras, S.A.E., et al., Genet. Anal. Biomol. Eng.—14:151-156 Cserzo, M., et al., Protein Eng–10(6):673-676 (1997). (1999). Dobelis, P., et al., Mol. Pharmacol.–62(2):334-342 (2002). Meksem, K., et al., Mol. Gen. Genet.—249:74-81 (1995). Dobson-Stone, C., et al., Eur: J. Hum. Genet.—10:773-781 (2002). Merikangas, K.R., et al., Arch Gen Psychiatryi–55:973-979 (1998). Ertekin-Taner, N., et al., Hum. Mol. Genet.—12,3133-3143 (2003). Needham-VanDevanter, D.R., et al., Nucleic Acids Res.— Fang, X. et al. J. Am. Chem. Soc.–121:2921-2922 (1999). 12(15):6159-6168 (1984). Feng, Y, et al., Am. J. Hum. Genet. 75: 112-121 (2004). Pianezza, M.L., et al. Sellers.E.M., and Tyndale, RF. Nicotine Zeng, Z. et al., Cell 127:621-633 (2006). metabolism defect reduces Smoking. Nature 393:750 (1998). Fodor, P.A., FASEB Journal 11:A879 (1997). Pritchard, J.K., et al., Genetics Society of America —155:945-959 Fodor, S.P.A. Science 277:393-395 (1997). (2000). Gelernter, J. et al., Am. J. Med. Genet. B Neuropsychiatr. Genet.— Roeder, K., et al., Am. J. Hum. Genet. 78,243-252 (2006). 128B:94-101 (2004). Saccone, S.F., et al., Genet. Epidemiol.—30:459-470 (2006). Grant, B.F., et al., Arch. Gen. Psychiatry—61:1107-1115 (2004). Saccone, S.F., et al., Hum. Mol. Genet.—16(1):36-49 (2006). Greenbaum, L., et al., Mol. Psychiatr.—11:312-322 (2006). Salminen, O., et al., Mol. Pharmacol.–65(6):1526-1535 (2004). Guatelli, J.C., et al., Proc. Natl. Acad. Sci. USA-87: 1874-1878 Sapolsky, R.J., et al., Genetic Analysis. Biomolecular Engineering— (1990). 14:187-192 (1999). Heath, A.C., et al., Addict. Behav.–18:19-34 (1993). Satagopan, J.M., et al., Biometrics—58:163-170 (2002). Heatherton, T.F., et al., Br. J. Addict.–86: 1119-1127 (1991). (Service (1998) Science 282:396–401(1998). Heatherton, T.F., et al., Br. J. Addict.–84:791-800 (1989). Shields, P.G., et al., Cancer Epidemiol. Biomarkers Prev. 7:453 Hegab, A.E., et al., J. Med. Genet.—41:(e27):1-7 (2004). 458 (1998). Hinds, D.A., et al., Science 307: 1072-1079 (2005). Skol, A.D., et al., Nat. Genet. 38(2):209-213 (2006). Hinds, D.A., et al., Am. J. Hum. Genet.—74:317-325 (2004). Sooknanan, R., et al., Biotechnology—13:563-564 (1995). Hochberg, Y, et al., Stat. Med. 9:811-818 (1990). Sokol, D.L., et al., Proc. Natl. Acad. Sci. U.S.A. 95:11538-11543 Hsuih, T.C.H., et al., J. Clin. Microbiol. 34(3):501-507 (1996). (1998). Hu, S., et al., Mol. Psychiatry 5:181-188 (2000). Spitz, M.R. et al., J. Natl. Cancer. Inst. 90(5):358-363 (1998). Iacono, W.G., et al., Arch. Gen. Psychiatry: 59.750-757 (2002). Stein, L.D., et al., Genome. Res.–12:1599-1610 (2002). Issaq, H.J., et al., (Analytical Chemistry: 75:149A-155A (2003). Stitzel, J.A., et al., Pharmacogenetics—11:331-339 (2001). Jeulin, C., et al., Am. J. Physiol. Lung Cell. Mol. Physiol.— Storey, J.D., J. R. Statist. Soc. B–64:479–498 (2002). 289:L636-L646 (2005). Storey, J.D., et al., Proc. Natl. Acad. Sci-100(16):9440-9445 Karadsheh, M. S., et al., J. Neurochem.—91: 1138-1150 (2004). (2003). Kostrikis, L.G., et al., Science 279:1228-1229 (1998).