Last updated: July 16, 2017 Young Kwang Lee, Ph. D. CONTACT Department of Chemistry, University of California, Berkeley, CA USA Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Lab, Berkeley, CA, USA Email: [email protected] Tel: +1-510-610-0087 EDUCATION Ph. D. in Chemistry 2008-2013 Seoul National University, Seoul, South Korea Advisors: Professor Jwa-Min Nam Thesis title: Actively Controllable Lipid Bilayer Platforms and Their Biosensing Applications M. S. in Chemistry 2005-2007 Kookmin University, Seoul, South Korea Advisor: Professor Young Rag Do 3+ Thesis title: Study on Enhanced Light Extraction Efficiency of Y2O3:Eu Thin-Film Phosphors Modified with Two-Dimensional Photonic Crystal Layers B. S. in Chemistry Kookmin University, Seoul, South Korea 2002-2005 Thesis title: Fabrication of Two-Dimensional Photonic Crystal Layers by Using Laser Hologram Lithography RESEARCH EXPERIENCES Nov. 01. 2013- Postdoctoral Research Present Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, CA, USA Molecular Biophysics and Integrated Bioimaing Division, Lawrence Berkeley National Lab, Berkeley, CA, USA Advisors: Professor Jay. T. Groves Project: Single-molecule imaging and analysis of signal transduction on in vitro reconstituted cell membrane platforms ACADEMIC HONORS Seoul Science Fellowship Program of Seoul City, South Korea 2008-2010 The Best Graduation Poster Awards, Department of Chemistry, Kookmin University 2005 The Early Graduation of Excellent Students, Kookmin University 2005 Last updated: July 16, 2017 PUBLICATIONS 20. Associating and dissociating nanodimer analysis for quantifying ultra-small amounts of DNA. K. Kim, J.-W. Oh, Y. K. Lee, J. Son J.-M. Nam Angew. Chem. Int. Ed. 10.1002/anie.201705330 (2017). 19. Mechanism of SOS PR-domain Autoinhibition Revealed by Single Molecule Assay on Native Protein from Lysate. Y. K. Lee, S. Low-Nam, Jean K. Chung, S. D. Hansen, S. Alvrez, H. Y. M. Lam, J. T. Groves. Nature Communications 8, 15061 (2017). 18. Optokinetically Encoded Nanoprobe-Based Multiplexing Strategy for MicroRNA Profiling S. Kim, J.-E. Park, W. Hwang, J. Seo, Y. K. Lee, J.-H. Hwang, J.-M. Nam J. Am. Chem. Soc. 139, 3558 (2017). 17. Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation. J. K. Chung*, Y. K. Lee*, H. Y. M. Lam*, J. T. Groves J. Am. Chem. Soc. 138, 1800 (2016). *Co-first author 16. Graphene-Templated Supported Lipid Bilayer Nanochannels W. Li, J. K. Chung, Y. K. Lee, J. T. Groves Nano Lett. 16, 5022 (2016) 15. Dark-Field-Based Observation of Single-Nanoparticle Dynamics on a Supported Lipid Bilayer for In Situ Analysis of Interacting Molecules and Nanoparticles. Y. K. Lee*, S. Kim*, J.-M. Nam ChemPhysChem 16, 77 (2015). *Co-first author 14. Massively Parallel and Highly Quantitative Single-Particle Analysis on Interactions between Nanoparticles on Supported Lipid Bilayer. Y. K. Lee, S. Kim, J.-W. Oh, J.-M. Nam J. Am. Chem. Soc. 136, 4081 (2014). Selected as JACS spotlights: J. Am. Chem. Soc. 136, 3321 (2014). Snapshots of Nanoparticles in Action Reveal Their Interactions. 13. Surface Passivation for Single-Molecule Protein Studies. S. D. Chandradoss, A. C. Haagsma, Y. K. Lee, J.-H. Hwang, J.-M. Nam and C. Joo J. Vis. Exp. (2014). doi: 10.3791/50549. 12. Lipid-Nanostructure Hybrids and Their Applications in Nanobiotechnology. Y. K. Lee*, H. Lee*, J.-M. Nam NPG Asia Materials 5, e48 (2013). *Co-first author 11. Electrofluidic Lipid Membrane Biosensor. Y. K. Lee, J.-M. Nam Small 8, 832 (2012). 10. Enhancement of Photoluminescence by Photonic Crystal Scattering and Nanocrystalline Surface 3+ Scattering from Y2O3:Tb Film Phosphors. J. R. Oh, B. K. Park, Y. K. Lee, Y.-D. Huh, Y. R. Do J. Electrochem Soc. 158, J316 (2011). 9. Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells. D.-H. Kim, H. Lee, Y. K. Lee, J.-M. Nam, A. Levchenko Adv. Mater. 22, 4551 (2010). 8. Effects of Symmetry, Shape and Structural Parameters of Two-Dimensional SiNx Photonic Crystal on the 3+ Extracted Light from Y2O3:Eu Film. J. R. Oh, Y. K. Lee, H. K. Park, Y. R. Do J. Appl. Phys. 105, 043103 (2009). Last updated: July 16, 2017 3+ 7. The Variation of the Enhanced Photoluminescence Efficiency of Y2O3:Eu Films with the Thickness to the Photonic Crystal Layer. K.-Y. Ko, Y. K. Lee, H. K. Park, Y.-C. Kim, Y. R. Do Opt. Express 16, 5689 (2008). 6. Periodic Growth of ZnO Nanorod Arrays on Two-Dimensional SiNx Nanohole Templates by Electrochemical Deposition. S. K. Park, Y. K. Lee, H. T. Kwak, C. R. Park, J. Park, Y. R. Do J. Phys. Chem. C 112, 4129 (2008). 2+ 5. Enhanced Light Extraction from SrGa2S4:Eu Film Phosphors Coated with Various Sizes of Polystyrene Nanosphere Monolayers. K. Y. Ko, K. N. Lee, Y. K. Lee, Y. R. Do J. Phys. Chem. C 112, 7594 (2008). 3+ 4. Strong Perturbation of the Guided Light within Y2O3:Eu Thin-Film Phosphors Coated with Two- Dimensional Air-Hole Photonic Crystal Arrays. Y. K. Lee, J. R. Oh, Y.-D. Huh, Y. R. Do Appl. Phys. Lett. 91, 231908 (2007). 3+ 3. Enhanced Extraction Efficiency of Y2O3:Eu Thin-Film Phosphors Coated with Hexagonally Close- Packed Polystyrene Nanosphere Monolayers. Y. K. Lee, J. R. Oh, Y. R. Do Appl. Phys. Lett. 91, 041907 (2007). 3+ 2. Optical Properties of Y2O3:Eu Thin-Film Phosphors Coated with 2D SiNx/Air Photonic Crystal Layers. Y. K. Lee, J. Y. Cho, C. R. Park, Y.-D. Huh, Y.-C. Kim, Y. R. Do Electrochem. Solid State Lett. 10, H82 (2007). 1. Structural Effect of a Two-Dimensional SiO2 Photonic Crystal Layer on Extraction Efficiency in Sputter- 3+ Deposited Y2O3:Eu Thin-Film Phosphors. K.-Y. Ko, Y. K. Lee, Y.-D. Huh, Y. R. Do J. Appl. Phys. 102, 013509 (2007). PATENTS 3. Artificial Cell Membrane Comprising Supported Lipid Bilayer Connected with Probes Having Controllable Mobility and Method for Analyzing Interaction Between Molecules Using the Same. J.-M. Nam, Y. K. Lee Patent Issued (10-1568-5650000, South Korea), Nov. 5, 2015. 2. Nanoparticle-Polynucleotide Complex and Preparation Method Thereof. S. B. Joo, J.-M. Nam, Y. K. Lee, Y. Kim, J.T. Kim, S. M. Cho Patent Pending (10-2012-0121217, South Korea), Oct. 30, 2012. 1. Nanoparticle-Nucleic Acid Complex and Method for Linearizing Target Nucleic Acid using Thereof. J. Y. Lee, J.-M. Nam, S. H. Kim, W. C. Lee, J. Y. Kim, J. W. Lee, Y. K. Lee, D.-K. Lim, J.-H. Hwang Application number (13/294596, USA), Nov. 11, 2011. SELECTED PRESENTATIONS 9. Single Molecule Assays of Full-Length SOS on Membranes Using Crude Cell Lysates. Y. K. Lee, Shalini Low-Nam, Scott D. Hansen, Steven Alvarez, Hiu Yue Monatrice Lam, Jay T. Groves 60th Biophysical Society Annual Meeting, Los Angeles, CA, USA, Mar. 2, 2016. 8. Monitoring Intermolecular Reactions on Nanoparticle-Modified Supported Lipid Bilayer Platforms. Y. K. Lee, S. Kim, J.-M. Nam 87th ACS Colloid & Surface Science Symposium, Riverside, CA, USA, Jun. 26, 2013. *Oral presentation 7 Active Plasmonic Coupling of Metal Nanoparticles on Fluid Lipid Membrane. Y. K. Lee, J.-M. Nam Last updated: July 16, 2017 The University of Tokyo-Seoul National University-National Taiwan University Chemistry Department Joint Symposium, Feb. 6, 2012. 6 Target Protein-Selective One-Dimensional Assembly of Lipid Bilayer-Coated Magnetic Particles. Y. K. Lee, J.-M. Nam US-Korea Joint Symposium of Nanotechnology Workshops, Gyeongju, Korea, June 1, 2011. 5. Unidirectional Self-Assembly of Artificial Cell Membrane-Coated Colloidal Particles. Y. K. Lee, J.-M. Nam Nano Korea 2010 Symposium, KINTEX, Goyang, Korea, Aug. 20, 2010. 4. Supported Lipid Bilayer-Based Electrophoretic Membrane Biosensor. Y. K. Lee, J.-M. Nam 83rd ACS Colloid & Surface Science Symposium, Columbia University, NY, USA, Jun. 17, 2009. 3 Highly Sensitive Membrane Biosensor Amplified by Electrophoretic Accumulation of Membrane Components. Y. K. Lee, J.-M. Nam 102nd KCS National Meeting, ICC Jeju, Korea, Oct. 17, 2008. 3+ 2. Enhanced Light Extraction Efficiency of Y2O3:Eu Thin-film Phosphors Modified with 2D Hexagonal Lattice Nanohole Patterns. Y. K. Lee, J. R. Oh, Y. Ro. Do 99th KCS National Meeting, COEX, Seoul, Korea, Apr. 20, 2007. 3+ 1. Efficient 2D SiNx/Air Photonic Crystal Layer on Y2O3:Eu thin-film phosphor. Y. K. Lee, K. Y. Ko, J. Y. Cho, Y. R. Do, Y.-D. Huh 209th ECS Meeting, Denver, CO, USA, May 8, 2006. .