Umar Mushtaq Department of Biotechnology Central University of Kashmir [email protected] Education: 1. Ph.D, 2015-2019, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India. 2. M Phil, 2012-2015, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India. 3. Master of Science, 2010-2012, Biotechnology (71.25% marks), Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India 4. Bachelor of Science, 2006-2009, (66.16 % marks), Islamia College of Science and Commerce, Srinagar, Jammu and Kashmir, India Awards: 1. Qualified Junior Research Fellowship under CSIR fellowship Scheme with secured rank 61 held on 22th June 2014. 2. Qualified joint CSIR-UGC NET with secured rank 35 held on 21th Dec 2014 3. Qualified ASRB/ICAR NET with 68% held on 03 April 2014 4. Qualified State Level Eligibility Test for Lecturership on 1st September 2013 5. Qualified joint CSIR-UGC NET with secured rank 48 held on 23th Dec 2012. 6. Qualified joint CSIR-UGC NET with secured rank 30 held on 17th June 2012. Research Interests: Signal Transduction in Alzheimer’s Disease Cancer and Molecular biology Current Position: Level: Assistant Professor (Contractual) Affiliation: Department of Biotechnology, Central University of Kashmir, J&K, India Research Statement: I have worked on the role of Syntrophins in Alzheimers disease (AD). Alzheimer’s disease is insidious progressive neurodegenerative disease and represents a critical public health concern. The disease is the leading cause of dementia, recognized by two major pathological markers, senile plaques and neuro-fibrillary tangles, along with an increase in the ROS production. MAP Kinases play a prominent role in the development and progression of this disease. MKK6/p38 kinases show increased expression and activation in the disease. Increased ROS generation is considered as early sign of AD and the mechanism which is involved in ROS production in this disease is not clear. Our work gives a most likely mechanism through which ROS is upregulated in this disease. We observed beta-amyloid activated MKK6 associates with SNTA1 and mediates its activation. Activated SNTA1 regulate the activation of small GTPase Rac1 and ROS production. Research Experience (6 years): Western Blot, Mammalian Cell Culture, Transfection, Transformation, molecular Cloning, Reactive Oxygen Species, Primer designing, PCR, Quantitative PCR, FACS, Apoptosis, Immunofluorescence, Molecular Biology, Cell Biology, Cell Signaling, , Phosphorylation. Articles in Communication: 02 (International) 1. Umar Mushtaq, Sumaiya Nabi, Sehar Saleem Bhat and Firdous Ahmad Khanday: Amyloid beta activates Alpha-1-Syntrohin in neuroblastoma cell lines: Implication on Rac1 activation, ROS production and cell death. (Research Article). 2. Umar Mushtaq, Muneesa Bashir, Sumaiya Nabi and Firdous A. Khanday: Epidermal Growth Factor Receptor and Integrins meet redox signaling through P66shc and Rac1. (Review Article). Published Articles: 06 (International) 1. Muneesa Bashir, Arif A Parray, Rafia A Baba, Hina F Bhat, Sehar S Bhat, Umar Mushtaq, Khurshid I Andrabi, Firdous A Khanday: β-Amyloid-evoked Apoptotic Cell Death is Mediated Through MKK6–p66shc Pathway. Neuromolecular medicine 10/2013; 16(1)., DOI:10.1007/s12017-013-8268-4 2. Rafia A. Baba, Umar Mushtaq, Arif A. Parray, Deeba Kirmani, Lateef A. Wani, Firdous A. Khanday. Involvement of Mitogen activated protein kinase kinase 6 in breast tumorogenesis. DOI:10.21474/IJAR01 3. Asma Ashraf Khan, Adil Gani, F.A. Masoodi, Umar Mushtaq, Azza Silotry Naik: Structural, rheological, antioxidant, and functional properties of β–glucan extracted from edible mushrooms Agaricus bisporus, Pleurotus ostreatus and Coprinus attrimentarius. Bioactive Carbohydrates and Dietary Fibre 07/2017; 11., DOI:10.1016/j.bcdf.2017.07.006 4. Sehar Saleem Bhat, Arif Ali Parray, Umar Mushtaq, Khalid Majid Fazili, Firdous Ahmad Khanday: Actin depolymerization mediated loss of SNTA1 phosphorylation and Rac1 activity has implications on ROS production, cell migration and apoptosis. Apoptosis 04/2016; 21(6)., DOI:10.1007/s10495-016-1241-6 5. Umar Mushtaq, Rafia Anjum Baba, Arif Ali Parray, Hina Fayaz Bhat, Sehar Saleem, Usma Manzoor, Sonaullah Kuchay, Lateef Wani, Firdous Ahmad Khanday: Mitogen Activated Protein Kinase Kinase-4 Upregulation is a Frequent Event in Human Stomach and Colon Cancers.JEM 8:10 ISSN: 2455-4774. 6. Arif Ali Parray, Rafia Anjum Baba, Hina Fayaz Bhat, Lateef Wani, Taseem Ahmad Mokhdomi, Umar Mushtaq, Sehar Saleem Bhat, Deeba Kirmani, Sanaullah Kuchay, Mudassir Maqbool Wani, Firdous Ahmad Khanday: MKK6 is Upregulated in Human Esophageal, Stomach, and Colon Cancers. Cancer Investigation 07/2014; 32(8)., DOI:10.3109/07357907.2014.933236 Book Chapters: 1. Umar Mushtaq, Firdous A. Khanday: Syntrophin. Encyclopedia of Signaling Molecules, 08/2018: pages 1-5; , DOI: 10.1007/978-1-4614-6438-9_102007-1 2. Umar Mushtaq, Firdous A. Khanday: Gamma-1-Syntrophin. Encyclopedia of Signaling Molecules, 01/2017: pages 2003-2007; , DOI:10.1007/978-1-4614-6438-9_101492-2. Book Published: Umar Mushtaq, Amrina Shafi, Firdous A. Khanday: MAP Kinase Signaling Cascade: Role in Development and progression of Alzheimers Disease. 2017, ISBN: 978-93-87374-09-6. Amrina Shafi, Umar Mushtaq, Insha Zahoor, Umer Majeed, Zubair A. Wani: Abiotic Stress Induced Changes In Plant Cell Wall Structure, Organization And Composition. 2017, ISBN: 978-93-87388-10-9. Amrina Shafi, Insha Zahoor,Mudasir A Mir, Umar Mushtaq: Plant Abiotic Stress Biology: Effect Of Salinity And Cold Stress In Plants. 2017, ISBN: 978-1-73031-369-1. Supervision Experience: Laboratory Supervisor to 4th semester PGs of Department of Biotechnology, University of Kashmir, J&K, India, 2016-Present Conferences/Workshops attended: Two days seminar on Research practices & applications in biological sciences: where we stand? Organized by faculty of veterinary sciences and animal husbandry,SKUAST-K, Srinagar on 18th july to 19th july 2018. International Conference on Cell Biology organized by CCMB, Hyderabad in 2018. International Congress of Cell Biology (ICCB), The Dynamic Cell: Molecules and Networks to Form and Function, organized by CSIR-Centre for Cellular & Molecular Biology (CCMB), Hyderabad, India, during 27th-31st January 2018. Poster presented. International Conference on Biotechnology and Biomedicines (ICBTBM-2017) held at Ludhiana, 17th December 2017 Workshop on Scholarly Writing & Plagiarism jointly organized by Allama Iqbal library, University of Kashmir and Springer Nature on 14th December, 2017 at University of Kashmir. International Conference on Renewable energy, Green technology & Environmental science organized by ASIAN SOCIETY FOR ACADEMIC RESEARCH held at New Delhi, India on 3rd December, 2017. National Seminar cum Workshop on Skill Development in Biotechnology organized by Department of Biotechnology and Bioinformatics, Sri Pratap College, Srinagar on 20th - 21st November 2017. 4th International Conference on Recent Trends and Advancements in Engineering and Technology (ICRTAET) organized by Shri Mata Vaishno Devi University, Katra on 3-4 November 2017. One Week Workshop on Research Methodology for Research Scholars of Science organized by UGC-Human Resource Development Centre, University of Kashmir, from 13th September to 19th September 2017. CME on flow cytometry “FLOW-CYTO 2016” organized by department of immunology & molecular medicine, SKIMS Beckman coulter india ltd on 2nd April 2016. International Conference on Cellular and Molecular Mechanisms of Disease Processes organized by Department of Biotechnology University of Kashmir in 2014. Published Abstracts: Umar Mushtaq, Firdous A. Khanday. Elucidating the role of sytrophin proteins in progression of Alzheimers disease. The 13th session of Jammu and Kashmir Science Congress, April 2-4, 2018. JKSC-800 Umar Mushtaq, Firdous A. Khanday. (2018), Syntrophin mediated signaling disturbaces in beta amyloid treated neuronal cells. International conference on cell biology CCMB, Hyderabad in 2018. Umar Mushtaq, Firdous A. Khanday. (2014), β-Amyloid mediated Activation of SNTG1: Implications for Alzheimer’s. International Conference on Cellular and Molecular Mechanisms of Disease Processes. .