Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 3, Number 3, Jul-Sep 1999 Previous Issue / Next Issue Genes CBFb (subunit b of core binding factor) (16q22). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 286-290. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/CBFbID45.html MYH11 (myosin heavy chain) (incomplete) (16p13). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 291-295. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/MYH11ID43.html PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) (10q23.3). Michel Longy. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 296-300. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PTENID158.html CBLb (Cas-Br-M (murine) ecotropic retroviral transforming sequence b) (3q). Olivier Rosnet. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 301-3055. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/CBLbID193.html CBLc (Cas-Br-M (murine) ecotropic retroviral transforming sequence c) (19q13.2). Olivier Rosnet. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 306-309. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/CBLcID194.html CBL (Cas-Br-M (murine) ecotropic retroviral transforming sequence) (11q23-q25). Olivier Rosnet. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 310-314. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 1999; 2 I URL : http://AtlasGeneticsOncology.org/Genes/CBLID171.html HLF (hepatic leukemia factor) (17q22). Franck Viguié. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 315-319. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/HLFID47.html RB1 (retinoblastoma) (13q14). Dietmar R Lohmann. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 320-325. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/RB1ID90.html Leukaemias -7/del(7q) in childhood. François Desangles. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 326-330. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/del7qChildID1152.html -7/del(7q) in adults. François Desangles. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 331-335. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/del7qID1093.html dic(9;20)(p11-13;q11). Barbara Gibbons. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 336-337. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/dic920ID1143.html High hyperdiploid acute lymphoblastic leukaemia. Barbara Gibbons. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 338-340. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/hyperploidID1085.html Severe hypodiploid acute lymphoblastic leukaemia. Barbara Gibbons. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 341-342. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/hypoploidyID1087.html del(16)(q22); inv(16)(p13q22); t(16;16)(p13;q22) - updated. Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 343-348. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/inv16.html Near haploid acute lymphoblastic leukaemia. Barbara Gibbons. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 349-350. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 1999; 2 II URL : http://AtlasGeneticsOncology.org/Anomalies/nearhaploidID1045.html 9p Rearrangements in ALL. Nyla A Heerema. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 351-353. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/9prearrALLID1156.html t(10;14)(q24;q11); t(7;10)(q34;q24) . Christine Pérot. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 354-357. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/1014ID1068.html t(1;18)(q25;q23). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 358-359. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t0118ID1162.html Solid Tumours Soft tissue tumors: Desmoplastic small round cell tumor. Christine Pérot. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 360-364. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/desmoplasticID5023.html Eye: Posterior uveal melanoma. Karen Sisley. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 365-368. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/UvealmelanomID5047.html Uterus: Carcinoma of the cervix. Niels B Atkin. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 369-373. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Tumors/CervixUteriID5046.html Cancer Prone Diseases Diamond-Blackfan anemia (DBA). Hope H. Punnett. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 374-375. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/DiamondBlackfanID10040.html Hyperparathyroidism-Jaw Tumor syndrome (HPT-JT). Maurine R Hobbs. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 376-379. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/Hyperpar-JawID10052.html Deep Insights Atlas Genet Cytogenet Oncol Haematol 1999; 2 III Minimal residual disease in acute lymphoblastic leukemia. Hélène Cavé. Atlas Genet Cytogenet Oncol Haematol 1999; 3 (3): 380-388. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Deep/MinResidDisID20007.html Case Reports Educational Items © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 1999; 2 IV Atlas of Genetics and Cytogenetics in Oncology and Haematology NONO Identity Hugo NONO Location Xq12 DNA/RNA Transcription alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550 Protein Description the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions. Expression wide Function binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all). Homology with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains. Implicated in Entity inv(X)(p11.2q12) in renal cell carcinoma -->NonO/TFE3 Disease only one case of papillary renal cell carcinoma Hybrid/Mutated 5' NONO- 3' TFE3 Gene Abnormal N-term NONO and most of it except the C-term proline rich sequence Protein fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop- Atlas Genet Cytogenet Oncol Haematol 1999; 2 -133- helix, and the leucine zipper); the reciprocal transcript is found External links Nomenclature Hugo NONO GDB NONO Entrez_Gene NONO 4841 non-POU domain containing, octamer-binding Cards Atlas NONOID168 GeneCards NONO Ensembl NONO CancerGene NONO Genatlas NONO GeneLynx NONO eGenome NONO euGene 4841 Genomic and cartography NONO - Xq12 chrX:70286488-70304037 + Xq13.1 (hg17- GoldenPath May_2004) Ensembl NONO - Xq13.1 [CytoView] NCBI Genes Cyto Gene Seq [Map View - NCBI] OMIM Disease map [OMIM] HomoloGene NONO Gene and transcription Genbank Y11289 [ SRS ] Y11289 [ ENTREZ ] Genbank AK055406 [ SRS ] AK055406 [ ENTREZ ] Genbank AU119361 [ SRS ] AU119361 [ ENTREZ ] Genbank BC002364 [ SRS ] BC002364 [ ENTREZ ] Genbank BC003129 [ SRS ] BC003129 [ ENTREZ ] RefSeq NM_007363 [ SRS ] NM_007363 [ ENTREZ ] RefSeq NT_086956 [ SRS ] NT_086956 [ ENTREZ ] AceView NONO AceView - NCBI TRASER NONO Traser - Stanford Unigene Hs.533282 [ SRS ] Hs.533282 [ NCBI ] HS533282 [ spliceNest ] Protein : pattern, domain, 3D structure SwissProt Q15233 [ SRS] Q15233 [ EXPASY ] Q15233 [ INTERPRO ] Prosite PS50102 RRM [ SRS ] PS50102 RRM [ Expasy ] Interpro IPR000504 RNA_rec_mot [ SRS ] IPR000504 RNA_rec_mot [ EBI ] Atlas Genet Cytogenet Oncol Haematol 1999; 2 -134- CluSTr Q15233 Pfam PF00076 RRM_1 [ SRS ] PF00076 RRM_1 [ Sanger ] pfam00076 [ NCBI- CDD ] Blocks Q15233 Polymorphism : SNP, mutations, diseases OMIM 300084 [ map ] GENECLINICS 300084 SNP NONO [dbSNP-NCBI] SNP NM_007363 [SNP-NCI] SNP NONO [GeneSNPs - Utah] NONO [SNP - CSHL] NONO] [HGBASE - SRS] General knowledge Family NONO [UCSC Family Browser] Browser SOURCE NM_007363 SMD Hs.533282 SAGE Hs.533282 Amigo function|DNA binding Amigo function|RNA binding Amigo process|RNA splicing Amigo process|mRNA processing Amigo component|nucleus Amigo function|pre-mRNA splicing factor activity BIOCARTA RNA polymerase III transcription PubGene NONO Other databases Probes Probe NONO Related clones (RZPD - Berlin) PubMed PubMed 11 Pubmed reference(s) in LocusLink Bibliography Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Dong B, Horowitz DS, Kobayashi R, Krainer AR Nucleic Acids Res