Report of The External Review Committee for The Institute of Medical Science The University of Tokyo March 2021 Contents Prologue (1) Goals and aim for External Review of IMSUT ............................................................................... 6 (2) Period of Review ............................................................................................................................. 6 (3) External Review Method ................................................................................................................. 6 (4) List of External Review of IMSUT Committee Members .............................................................. 7 I. General Statement: Current Status of IMSUT (1) Mission and Features ....................................................................................................................... 9 (2) Organization .................................................................................................................................. 10 (3) Status of Current Research Activities ............................................................................................ 11 1) Implementation System and Support/Promotion System for Research ...................................... 11 2) Initiatives and quality improvement in research activities ......................................................... 17 3) Academic Papers/Patents/Conference Presentations etc. ............................................................ 27 4) Research Funds ........................................................................................................................... 31 5) Research Activities through International Collaboration ............................................................ 35 6) Contribution to Academic Community ....................................................................................... 36 (4) Status of Research Results ............................................................................................................ 39 (5) Status of Education Activity .......................................................................................................... 43 (6) Status of Social Cooperation ......................................................................................................... 43 (7) Issues and Future Prospects ........................................................................................................... 46 II. Detailed Exposition Department of Microbiology and Immunology .................................................................................. 49 Division of Virology ....................................................................................................................... 51 Division of Infectious Genetics ...................................................................................................... 55 Division of Molecular Virology ...................................................................................................... 57 Division of Vaccine Science ........................................................................................................... 60 Division of Malaria Immunology ................................................................................................... 63 Department of Cancer Biology ........................................................................................................... 66 Division of Molecular Pathology .................................................................................................... 69 Division of Cellular and Molecular Biology (-2020.3) ................................................................... 73 Division of Genetics ....................................................................................................................... 76 Division of Cancer Cell Biology ..................................................................................................... 79 Department of Basic Medical Sciences .............................................................................................. 82 1 Division of Molecular Cell Signaling (-2017.3) ............................................................................. 84 Division of Neuronal Network ........................................................................................................ 86 Division of Cell Signaling and Molecular Medicine ...................................................................... 88 Human Genome Center....................................................................................................................... 90 Laboratory of DNA Information Analysis (-2020.3) ...................................................................... 93 Laboratory of Genome Technology ................................................................................................ 93 Laboratory of Genome Database .................................................................................................... 93 Laboratory of Sequence Analysis ................................................................................................... 93 Division of Computational Science (Health Intelligence Center) (-2020.3) ................................... 93 Laboratory of Molecular Medicine ................................................................................................. 96 Laboratory of Functional Analysis in Silico ................................................................................... 99 Department of Public Policy ......................................................................................................... 102 Division of Medical Data Informatics .......................................................................................... 104 Division of Health Medical Intelligence ....................................................................................... 106 Division of Metagenome Medicine............................................................................................... 110 Center for Experimental Medicine and Systems Biology ................................................................. 112 Laboratory of Developmental Genetics (-2018.3) ........................................................................ 115 Division of Stem Cell Pathology .................................................................................................. 117 Laboratory of Innate Immunity ..................................................................................................... 120 Laboratory of Reproductive Systems Biology .............................................................................. 122 Laboratory of Systems Biology (-2019.3) .................................................................................... 124 Division of Genome Engineering ................................................................................................. 126 Advanced Clinical Research Center ................................................................................................. 128 Division of Molecular Therapy ..................................................................................................... 130 Division of Cellular Therapy ........................................................................................................ 133 Division of Infectious Diseases .................................................................................................... 136 Division of Clinical Genome Research ......................................................................................... 139 Division of Innovative Cancer Therapy ........................................................................................ 142 Division of Advanced Medicine Promotion .................................................................................. 144 Division of Advanced Genome Medicine ..................................................................................... 146 Division of Genetic Therapeutics (-2018.3) .................................................................................. 148 Division of Bioethics .................................................................................................................... 150 Center for Stem Cell Biology and Regenerative Medicine ............................................................... 153 Division of Stem Cell and Molecular Medicine ........................................................................... 156 Division of Regenerative Medicine .............................................................................................. 158 Division of Stem Cell Transplantation .......................................................................................... 161 2 Division of Stem Cell Processing/Stem Cell Bank ....................................................................... 163 Division of Stem Cell Signaling ................................................................................................... 165 Division of Stem Cell Dynamics (-2019.3) .................................................................................. 168 Division of Stem Cell Cellomics (-2019.5) .................................................................................. 171 Division of Experimental Pathology ............................................................................................. 173 Division of Stem Cell Biology .....................................................................................................