Putrescine dihydrochloride Product Number P7505 Store at Room Temperature Product Description Preparation Instructions Molecular Formula: C4H12N2 · 2HCl This product is soluble in water (100 mg/ml), yielding a Molecular Weight: 161.1 clear, colorless solution. CAS Number: 333-93-7 Melting point: 290 °C1; 280 °C with decomposition; Storage/Stability >275 °C2 Aqueous solutions are stable at 2-8 °C for one month. Synonyms: Putrescine dihydrochloride; Frozen aliquots may also be stored. 1,4-Butanediamine dihydrochloride; tetramethylenediamine dihydrochloride References 1. Dictionary of Organic Compounds, 5th ed., Putrescine is a biogenic polyamine and precursor of Buckingham, J., ed., Chapman and Hall (New spermidine. It is formed via decarboxylation of York, NY: 1982), Entry# B-03464. ornithine or by decarboxylation of arginine followed by 2. The Merck Index, 12th ed., Entry# 8134. hydrolysis.2 3. Pegg, A. E., et al., Formation and interconversion of putrescine and spermidine in mammalian cells. Information on the formation and interconversion of Adv. Enzyme Regul., 19, 427-451 (1980). putrescine and spermidine in mammalian cells3 and on 4. Mach, M., et al., Regulation of tRNA the regulation of tRNA methyl transferase activity by methyltransferase activities by spermidine and putrescine has been published.4 The alteration of the putrescine. Inhibition of polyamine synthesis and DNA conformation in rat brain tumor cells by depletion tRNA methylation by alpha-methylornithine or of intracellular putrescine has also been published.5 A 1,3-diaminopropan-2-ol in Dictyostelium. Biochem. review article on the formation of GABA, the major J., 202(1), 153-162 (1982). inhibitory neurotransmitter in vertebrate brains, from 5. Hung, D. T., et al., Depletion of intracellular putrescine has been published.6 polyamines may alter DNA conformation in 9L rat brain tumor cells. Science, 221(4608), 368-370 Precautions and Disclaimer (1983). For Laboratory Use Only. Not for drug, household or 6. Seiler, N., On the role of GABA in vertebrate other uses. polyamine metabolism. Physiol. Chem. Phys., 12(5), 411-429 (1980). IRB/RXR 1/08 Sigma brand productsSigma brand are sold products through are Sigma sold through-Aldrich, Sigma-Aldrich, Inc. Inc. Sigma-Aldrich,Sigma-Aldrich, Inc. warrants that Inc. itswarrants products that conform its products to the conform information to the contained information in this contained and other in thisSigma and-Aldrich other Sigma-Aldrich publications. publications.Purchaser Purchaser must determinemust the determine suitability theof the suitability product(s) of the for product(s)their particular for their use. particular Additional use. terms Additional and conditions terms and may conditions apply. Please may apply. see reverse Please side see ofreverse side of the invoice or packing slip. the invoice or packing slip. .